PMID- 28545356
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20180605
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 25
IP  - 4
DP  - 2018 Feb 12
TI  - Drug Delivery Systems For Anti-Cancer Active Complexes of Some Coinage Metals.
PG  - 493-505
LID - 10.2174/0929867324666170511152441 [doi]
AB  - BACKGROUND: Although cisplatin and a number of platinum complexes have widely 
      been used for the treatment of neoplasia, patients receiving these treatments 
      have frequently suffered from their severe toxic side effects, the development of 
      resistance with consequent relapse. In the recent decades, numerous complexes of 
      coinage metals including that of gold, copper and silver have been reported to 
      display promising in vitro and/or in vivo anti-cancer activities as well as 
      potent activities towards cisplatin-resistant tumors. Nevertheless, the medical 
      development of these metal complexes has been hampered by their instability in 
      aqueous solutions and the nonspecific binding in biological systems. METHODS: One 
      of the approaches to overcome these problems is to design and develop adequate 
      drug delivery systems (DDSs) for the transport of these complexes. By 
      functionalization, encapsulation or formulation of the metal complexes, several 
      types of DDSs have been reported to improve the desired pharmacological profile 
      of the metal complexes, improving their overall stability, bioavailability, 
      anti-cancer activity and reducing their toxicity towards normal cells. 
      CONCLUSION: In this review, we summarized the recent findings for different DDSs 
      for various anti- cancer active complexes of some coinage metals.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Chemistry, Shantou University 243 Da Xue Road, Shantou, Guangdong 
      515063, China.
FAU - Saint-Germain, Camille
AU  - Saint-Germain C
AD  - Department of Chemistry, Shantou University 243 Da Xue Road, Shantou, Guangdong 
      515063, China.
AD  - Paul Sabatier University, 118 Route de Narbonne, F-31062 Toulouse, Toulouse, 
      France.
FAU - He, Guiling
AU  - He G
AD  - Department of Chemistry, Shantou University 243 Da Xue Road, Shantou, Guangdong 
      515063, China.
AD  - Guangzhou Lee & Man Technology Company Limited, Guangzhou, Guangdong, P. R. 
      China.
FAU - Sun, Raymond Wai-Yin
AU  - Sun RW
AD  - Department of Chemistry, Shantou University 243 Da Xue Road, Shantou, Guangdong 
      515063, China.
AD  - Guangzhou Lee & Man Technology Company Limited, Guangzhou, Guangdong, P. R. 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Metals)
SB  - IM
MH  - Antineoplastic Agents/administration & dosage/*chemistry/*pharmacology
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Metals/*administration & dosage/*chemistry/therapeutic use
MH  - Neoplasms/*drug therapy
OTO - NOTNLM
OT  - Cancer
OT  - coinage metal
OT  - copper
OT  - drug delivery system
OT  - gold
OT  - silver.
EDAT- 2017/05/27 06:00
MHDA- 2018/03/20 06:00
CRDT- 2017/05/27 06:00
PHST- 2016/08/19 00:00 [received]
PHST- 2016/01/10 00:00 [revised]
PHST- 2017/01/02 00:00 [accepted]
PHST- 2017/05/27 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2017/05/27 06:00 [entrez]
AID - CMC-EPUB-83429 [pii]
AID - 10.2174/0929867324666170511152441 [doi]
PST - ppublish
SO  - Curr Med Chem. 2018 Feb 12;25(4):493-505. doi: 10.2174/0929867324666170511152441.