PMID- 28545736
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20220318
IS  - 1879-0305 (Electronic)
IS  - 1359-6101 (Linking)
VI  - 35
DP  - 2017 Jun
TI  - Amino-acid sensing and degrading pathways in immune regulation.
PG  - 37-45
LID - S1359-6101(17)30076-X [pii]
LID - 10.1016/j.cytogfr.2017.05.004 [doi]
AB  - Indoleamine 2,3-dioxygenases (IDOs) - belonging in the heme dioxygenase family 
      and degrading tryptophan - are responsible for the de novo synthesis of 
      nicotinamide adenine dinucleotide (NAD(+)). As such, they are expressed by a 
      variety of invertebrate and vertebrate species. In mammals, IDO1 has remarkably 
      evolved to expand its functions, so to become a prominent homeostatic regulator, 
      capable of modulating infection and immunity in multiple ways, including local 
      tryptophan deprivation, production of biologically active tryptophan catabolites, 
      and non-enzymatic cell-signaling activity. Much like IDO1, arginase 1 (Arg1) is 
      an immunoregulatory enzyme that catalyzes the degradation of arginine. Here, we 
      discuss the possible role of amino-acid degradation as related to the evolution 
      of the immune systems and how the functions of those enzymes are linked by an 
      entwined pathway selected by phylogenesis to meet the newly arising needs imposed 
      by an evolving environment.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Grohmann, Ursula
AU  - Grohmann U
AD  - Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy. 
      Electronic address: ursula.grohmann@unipg.it.
FAU - Mondanelli, Giada
AU  - Mondanelli G
AD  - Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
FAU - Belladonna, Maria L
AU  - Belladonna ML
AD  - Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
FAU - Orabona, Ciriana
AU  - Orabona C
AD  - Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
FAU - Pallotta, Maria T
AU  - Pallotta MT
AD  - Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
FAU - Iacono, Alberta
AU  - Iacono A
AD  - Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
FAU - Puccetti, Paolo
AU  - Puccetti P
AD  - Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
FAU - Volpi, Claudia
AU  - Volpi C
AD  - Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170518
PL  - England
TA  - Cytokine Growth Factor Rev
JT  - Cytokine & growth factor reviews
JID - 9612306
RN  - 0 (Amino Acids)
RN  - 0 (IDO1 protein, human)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 8DUH1N11BX (Tryptophan)
RN  - EC 3.5.3.1 (Arginase)
SB  - IM
MH  - Amino Acids/*metabolism
MH  - Animals
MH  - Arginase/metabolism
MH  - Dendritic Cells/enzymology/*immunology
MH  - Gene Expression Regulation
MH  - Humans
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics/metabolism
MH  - Interferon-gamma/immunology
MH  - Interleukin-4/immunology
MH  - Mice
MH  - Neoplasms/immunology/metabolism
MH  - Signal Transduction
MH  - Transforming Growth Factor beta1/immunology
MH  - Tryptophan/metabolism
OTO - NOTNLM
OT  - Arg1
OT  - Dendritic cell
OT  - IDO1
OT  - Immune regulation
EDAT- 2017/05/27 06:00
MHDA- 2018/03/20 06:00
CRDT- 2017/05/27 06:00
PHST- 2017/05/15 00:00 [received]
PHST- 2017/05/15 00:00 [accepted]
PHST- 2017/05/27 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2017/05/27 06:00 [entrez]
AID - S1359-6101(17)30076-X [pii]
AID - 10.1016/j.cytogfr.2017.05.004 [doi]
PST - ppublish
SO  - Cytokine Growth Factor Rev. 2017 Jun;35:37-45. doi: 
      10.1016/j.cytogfr.2017.05.004. Epub 2017 May 18.