PMID- 28546015
OWN - NLM
STAT- MEDLINE
DCOM- 20180124
LR  - 20220408
IS  - 1440-1592 (Electronic)
IS  - 1323-8930 (Linking)
VI  - 67
IP  - 1
DP  - 2018 Jan
TI  - Allergic bronchopulmonary aspergillosis in Japan: A nationwide survey.
PG  - 79-84
LID - S1323-8930(17)30052-7 [pii]
LID - 10.1016/j.alit.2017.04.011 [doi]
AB  - BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is an allergic 
      pulmonary disease characterized by a hypersensitivity reaction to Aspergillus 
      species colonizing the airways. The clinical characteristics of ABPA may differ 
      depending on genetic and environmental background. We performed a nationwide 
      survey to determine the clinical characteristics of ABPA in Japan. METHODS: In 
      2013, a questionnaire on physician-diagnosed ABPA/allergic bronchopulmonary 
      mycosis was sent to 903 medical centers specializing in respiratory or allergic 
      diseases. Cases fulfilling the following criteria were categorized as possible 
      ABPA-central bronchiectasis (ABPA-CB): 1) presence of specific serum 
      immunoglobulin E (IgE) antibodies or a positive skin reaction to Aspergillus, and 
      2) bronchiectasis or mucoid impaction in the central bronchi. RESULTS: Of 499 
      physician-diagnosed cases reported by 132 clinical centers, 358 cases met the 
      criteria for possible ABPA-CB. Median age of ABPA-CB onset was 57 (interquartile 
      range, 44-68) years; later-onset disease, developing >/=50 years of age, accounted 
      for 66% of the cases and was associated with female sex, delayed onset of asthma, 
      and lower levels of serum IgE. A third of the patients (120 patients, 34%) 
      exhibited low levels of serum total IgE (<1000 IU/mL). Aspergillus species were 
      isolated from sputum in 126/213 cases (59%), and Schizophyllum commune was 
      identified in 12 (6%) patients. During the course of the treatment, ABPA recurred 
      in 169 (48%) cases. CONCLUSIONS: This nationwide survey identified several unique 
      clinical characteristics of ABPA in Japan, such as late-onset, relatively lower 
      serum IgE levels, and frequent recurrences/flares.
CI  - Copyright (c) 2017 Japanese Society of Allergology. Production and hosting by 
      Elsevier B.V. All rights reserved.
FAU - Oguma, Tsuyoshi
AU  - Oguma T
AD  - Division of Pulmonary Medicine, Department of Medicine, Tokai University School 
      of Medicine, Kanagawa, Japan.
FAU - Taniguchi, Masami
AU  - Taniguchi M
AD  - Clinical Research Center for Allergy and Rheumatology, Sagamihara National 
      Hospital, Kanagawa, Japan.
FAU - Shimoda, Terufumi
AU  - Shimoda T
AD  - Clinical Research Center, Fukuoka National Hospital, Fukuoka, Japan.
FAU - Kamei, Katsuhiko
AU  - Kamei K
AD  - Division of Clinical Research, Medical Mycology Research Center, Chiba 
      University, Chiba, Japan.
FAU - Matsuse, Hiroto
AU  - Matsuse H
AD  - Division of Respirology, Department of Internal Medicine, Toho University Ohashi 
      Medical Center, Tokyo, Japan.
FAU - Hebisawa, Akira
AU  - Hebisawa A
AD  - Clinical Research Center, Tokyo National Hospital, Tokyo, Japan.
FAU - Takayanagi, Noboru
AU  - Takayanagi N
AD  - Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory 
      Center, Saitama, Japan.
FAU - Konno, Satoshi
AU  - Konno S
AD  - First Department of Medicine, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
FAU - Fukunaga, Koichi
AU  - Fukunaga K
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University School of 
      Medicine, Tokyo, Japan.
FAU - Harada, Kazuki
AU  - Harada K
AD  - Division of Pulmonary Medicine, Department of Medicine, Tokai University School 
      of Medicine, Kanagawa, Japan.
FAU - Tanaka, Jun
AU  - Tanaka J
AD  - Division of Pulmonary Medicine, Department of Medicine, Tokai University School 
      of Medicine, Kanagawa, Japan.
FAU - Tomomatsu, Katsuyoshi
AU  - Tomomatsu K
AD  - Division of Pulmonary Medicine, Department of Medicine, Tokai University School 
      of Medicine, Kanagawa, Japan.
FAU - Asano, Koichiro
AU  - Asano K
AD  - Division of Pulmonary Medicine, Department of Medicine, Tokai University School 
      of Medicine, Kanagawa, Japan. Electronic address: ko-asano@tokai-u.jp.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
DEP - 20170523
PL  - England
TA  - Allergol Int
JT  - Allergology international : official journal of the Japanese Society of 
      Allergology
JID - 9616296
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Aspergillosis, Allergic 
      Bronchopulmonary/blood/epidemiology/immunology/microbiology
MH  - *Aspergillus
MH  - *Bronchiectasis/blood/epidemiology/immunology/microbiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - *Schizophyllum
MH  - *Surveys and Questionnaires
OTO - NOTNLM
OT  - Allergic bronchopulmonary aspergillosis
OT  - Aspergillus
OT  - Bronchiectasis
OT  - Immunoglobulin E
OT  - Schizophyllum commune
EDAT- 2017/05/27 06:00
MHDA- 2018/01/25 06:00
CRDT- 2017/05/27 06:00
PHST- 2016/12/26 00:00 [received]
PHST- 2017/04/02 00:00 [revised]
PHST- 2017/04/13 00:00 [accepted]
PHST- 2017/05/27 06:00 [pubmed]
PHST- 2018/01/25 06:00 [medline]
PHST- 2017/05/27 06:00 [entrez]
AID - S1323-8930(17)30052-7 [pii]
AID - 10.1016/j.alit.2017.04.011 [doi]
PST - ppublish
SO  - Allergol Int. 2018 Jan;67(1):79-84. doi: 10.1016/j.alit.2017.04.011. Epub 2017 
      May 23.