PMID- 28546953
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2228-5652 (Print)
IS  - 2228-5660 (Electronic)
IS  - 2228-5652 (Linking)
VI  - 7
IP  - 1
DP  - 2017
TI  - Perspective highlights on biodegradable polymeric nanosystems for targeted 
      therapy of solid tumors.
PG  - 49-57
LID - 10.15171/bi.2017.07 [doi]
AB  - Introduction: Polymeric nanoparticles (NPs) formulated using biodegradable 
      polymers offer great potential for development of de novo drug delivery systems 
      (DDSs) capable of delivering a wide range of bioactive agents. They can be 
      engineered as advanced multifunctional nanosystems (NSs) for simultaneous imaging 
      and therapy known as theranostics or diapeutics. Methods: A brief prospective is 
      provided on biomedical importance and applications of biodegradable polymeric NSs 
      through reviewing the recently published literature. Results: Biodegradable 
      polymeric NPs present unique characteristics, including: nanoscaled structures, 
      high encapsulation capacity, biocompatibility with non-thrombogenic and 
      non-immunogenic properties, and controlled-/sustained-release profile for 
      lipophilic and hydrophilic drugs. Once administered in vivo, all classes of 
      biodegradable polymers (i.e., synthetic, semi-synthetic, and natural polymers) 
      are subjected to enzymatic degradation; and hence, transformation into byproducts 
      that can be simply eliminated from the human body. Natural and semi-synthetic 
      polymers have been shown to be highly stable, much safer, and offer a 
      non-/less-toxic means for specific delivery of cargo drugs in comparison with 
      synthetic polymers. Despite being biocompatible and enzymatically-degradable, 
      there are some drawbacks associated with these polymers such as batch to batch 
      variation, high production cost, structural complexity, lower bioadhesive 
      potential, uncontrolled rate of hydration, and possibility of microbial spoilage. 
      These pitfalls have bolded the importance of synthetic counterparts despite their 
      somewhat toxicity. Conclusion: Taken all, to minimize the inadvertent effects of 
      these polymers and to engineer much safer NSs, it is necessary to devise 
      biopolymers with desirable chemical and biochemical modification(s) and 
      polyelectrolyte complex formation to improve their drug delivery capacity in 
      vivo.
FAU - Fathi, Marziyeh
AU  - Fathi M
AD  - Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Barar, Jaleh
AU  - Barar J
AD  - Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
AD  - Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170220
PL  - Iran
TA  - Bioimpacts
JT  - BioImpacts : BI
JID - 101558125
PMC - PMC5439389
OTO - NOTNLM
OT  - Advanced drug delivery systems
OT  - Biodegradable polymers
OT  - Natural polymers
OT  - Synthetic and semi-synthetic polymers
OT  - Targeted therapy
EDAT- 2017/05/27 06:00
MHDA- 2017/05/27 06:01
PMCR- 2017/01/01
CRDT- 2017/05/27 06:00
PHST- 2017/02/03 00:00 [received]
PHST- 2017/02/06 00:00 [accepted]
PHST- 2017/05/27 06:00 [entrez]
PHST- 2017/05/27 06:00 [pubmed]
PHST- 2017/05/27 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.15171/bi.2017.07 [doi]
PST - ppublish
SO  - Bioimpacts. 2017;7(1):49-57. doi: 10.15171/bi.2017.07. Epub 2017 Feb 20.