PMID- 28547794
OWN - NLM
STAT- MEDLINE
DCOM- 20180717
LR  - 20210109
IS  - 1755-5949 (Electronic)
IS  - 1755-5930 (Print)
IS  - 1755-5930 (Linking)
VI  - 23
IP  - 7
DP  - 2017 Jul
TI  - Antidepressant-like effects of tetrahydroxystilbene glucoside in mice: 
      Involvement of BDNF signaling cascade in the hippocampus.
PG  - 627-636
LID - 10.1111/cns.12708 [doi]
AB  - BACKGROUND AND AIMS: Current antidepressants in clinic need weeks of 
      administration and always have significant limitations. Tetrahydroxystilbene 
      glucoside (TSG) is one of the major bioactive ingredients of Polygonum 
      multiflorum with neuroprotective effects. This study aimed to evaluate the 
      antidepressant effects of TSG in mice. METHODS: The antidepressant-like effects 
      of TSG in mice were examined in the forced swim test (FST), tail suspension test 
      (TST), and chronic social defeat stress (CSDS) model of depression. The effects 
      of CSDS and TSG on the hippocampal brain-derived neurotrophic factor (BDNF) 
      signaling pathway and neurogenesis were further investigated. Moreover, the 
      pharmacological inhibitors and lentiviral-shRNA were used to explore the 
      antidepressant mechanisms of TSG. RESULTS: TSG produced antidepressant-like 
      effects in the FST and TST and also reversed the CSDS-induced depressive-like 
      symptoms. Moreover, TSG treatment significantly restored the decreased 
      hippocampal BDNF signaling pathway and neurogenesis in CSDS mice. Importantly, 
      blockade of the hippocampal BDNF system fully abolished the antidepressant-like 
      effects of TSG in mice. CONCLUSION: In conclusion, TSG produces 
      antidepressant-like effects in mice via enhancement of the hippocampal BDNF 
      system.
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Wang, Hao
AU  - Wang H
AD  - Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 
      Jiangsu, China.
AD  - Provincial key laboratory of Inflammation and Molecular Drug Target, Nantong, 
      Jiangsu, China.
FAU - Zhao, Ying
AU  - Zhao Y
AD  - Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Wang, Ying-Jie
AU  - Wang YJ
AD  - Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 
      Jiangsu, China.
AD  - Provincial key laboratory of Inflammation and Molecular Drug Target, Nantong, 
      Jiangsu, China.
FAU - Song, Lu
AU  - Song L
AD  - Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 
      Jiangsu, China.
AD  - Provincial key laboratory of Inflammation and Molecular Drug Target, Nantong, 
      Jiangsu, China.
FAU - Wang, Jin-Liang
AU  - Wang JL
AD  - Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 
      Jiangsu, China.
AD  - Provincial key laboratory of Inflammation and Molecular Drug Target, Nantong, 
      Jiangsu, China.
FAU - Huang, Chao
AU  - Huang C
AD  - Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 
      Jiangsu, China.
AD  - Provincial key laboratory of Inflammation and Molecular Drug Target, Nantong, 
      Jiangsu, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 
      Jiangsu, China.
AD  - Provincial key laboratory of Inflammation and Molecular Drug Target, Nantong, 
      Jiangsu, China.
FAU - Jiang, Bo
AU  - Jiang B
AUID- ORCID: 0000-0002-1577-7272
AD  - Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 
      Jiangsu, China.
AD  - Provincial key laboratory of Inflammation and Molecular Drug Target, Nantong, 
      Jiangsu, China.
LA  - eng
PT  - Journal Article
DEP - 20170525
PL  - England
TA  - CNS Neurosci Ther
JT  - CNS neuroscience & therapeutics
JID - 101473265
RN  - 0 (2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glucosides)
RN  - 0 (Stilbenes)
RN  - 333DO1RDJY (Serotonin)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Chronic Disease
MH  - Depressive Disorder/*drug therapy/metabolism/pathology
MH  - Disease Models, Animal
MH  - Dominance-Subordination
MH  - Glucosides/*pharmacology
MH  - Hippocampus/*drug effects/metabolism/pathology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Motor Activity/drug effects
MH  - Neurogenesis/drug effects/physiology
MH  - Receptor, trkB/antagonists & inhibitors/metabolism
MH  - Serotonin/metabolism
MH  - Signal Transduction/drug effects
MH  - Stilbenes/*pharmacology
MH  - Stress, Psychological/drug therapy/metabolism/pathology
PMC - PMC6492667
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - chronic social defeat stress
OT  - depression
OT  - tetrahydroxystilbene glucoside
COIS- The authors declare that there is no conflict of interests.
EDAT- 2017/05/27 06:00
MHDA- 2018/07/18 06:00
PMCR- 2017/05/25
CRDT- 2017/05/27 06:00
PHST- 2017/03/24 00:00 [received]
PHST- 2017/05/02 00:00 [revised]
PHST- 2017/05/03 00:00 [accepted]
PHST- 2017/05/27 06:00 [pubmed]
PHST- 2018/07/18 06:00 [medline]
PHST- 2017/05/27 06:00 [entrez]
PHST- 2017/05/25 00:00 [pmc-release]
AID - CNS12708 [pii]
AID - 10.1111/cns.12708 [doi]
PST - ppublish
SO  - CNS Neurosci Ther. 2017 Jul;23(7):627-636. doi: 10.1111/cns.12708. Epub 2017 May 
      25.