PMID- 28548694 OWN - NLM STAT- MEDLINE DCOM- 20171103 LR - 20171103 IS - 1551-3793 (Electronic) IS - 1551-3777 (Linking) VI - 13 IP - 6 DP - 2017 Nov TI - Towards a proportionality assessment of risk reduction measures aimed at restricting the use of persistent and bioaccumulative substances. PG - 1100-1112 LID - 10.1002/ieam.1949 [doi] AB - International chemicals legislation aims at adequately controlling persistent organic pollutants (POPs) and substances of very high concern (SVHCs), such as persistent, bioaccumulative, and toxic (PBT) and very persistent and very bioaccumulative (vPvB) substances, with a view to progressively substitute these substances with suitable less-hazardous alternatives. Using cost-effectiveness analysis (CEA) to assess the (dis)proportionality of measures to control such substances (collectively called "PBT" in the present paper) requires benchmarks. The present paper provides building blocks for possible benchmarks by looking at the cost-effectiveness estimates for regulatory measures that have been applied or considered for various PBT substances. These cost-effectiveness estimates vary widely, and the main factors possibly explaining this variation are discussed. The available cost estimates currently do not allow deriving a value for society's willingness to pay to reduce PBT presence, use, and emissions because decisions referring explicitly to these estimates are scarce. Roughly speaking, the available evidence suggests that measures costing less than euro1000 per kilogram PBT use or emission reduction will usually not be rejected for reasons of disproportionate costs, whereas for measures with costs above euro50 000 per kilogram PBT such a rejection is likely. More research is needed to strengthen the evidence base and further elaborate a systematic approach toward proportionality benchmarking. Integr Environ Assess Manag 2017;13:1100-1112. (c) 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC). CI - (c) 2017 The Authors. Integrated Environmental Assessment and Management Published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC). FAU - Oosterhuis, Frans AU - Oosterhuis F AUID- ORCID: 0000-0001-6410-2426 AD - Institute for Environmental Studies, Vrije Universiteit Amsterdam, the Netherlands. FAU - Brouwer, Roy AU - Brouwer R AD - The Water Institute and Department of Economics, University of Waterloo, Canada. FAU - Janssen, Martien AU - Janssen M AD - National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. FAU - Verhoeven, Julia AU - Verhoeven J AD - National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. FAU - Luttikhuizen, Cees AU - Luttikhuizen C AD - Ministry of Infrastructure and the Environment, The Hague, the Netherlands. LA - eng PT - Journal Article DEP - 20170624 PL - United States TA - Integr Environ Assess Manag JT - Integrated environmental assessment and management JID - 101234521 RN - 0 (Environmental Pollutants) RN - 0 (Hazardous Substances) SB - IM MH - Ecotoxicology MH - Environmental Exposure/legislation & jurisprudence/*statistics & numerical data MH - Environmental Monitoring MH - *Environmental Policy MH - Environmental Pollutants/analysis/*metabolism/standards MH - Environmental Pollution/*legislation & jurisprudence/statistics & numerical data MH - Hazardous Substances MH - Risk Assessment OTO - NOTNLM OT - PBT and vPvB substances OT - POPs OT - Proportionality assessment OT - REACH EDAT- 2017/05/27 06:00 MHDA- 2017/11/04 06:00 CRDT- 2017/05/27 06:00 PHST- 2016/04/20 00:00 [received] PHST- 2016/08/31 00:00 [revised] PHST- 2017/05/16 00:00 [accepted] PHST- 2017/05/27 06:00 [pubmed] PHST- 2017/11/04 06:00 [medline] PHST- 2017/05/27 06:00 [entrez] AID - 10.1002/ieam.1949 [doi] PST - ppublish SO - Integr Environ Assess Manag. 2017 Nov;13(6):1100-1112. doi: 10.1002/ieam.1949. Epub 2017 Jun 24.