PMID- 28549401
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20180611
IS  - 1547-6901 (Electronic)
IS  - 1547-691X (Linking)
VI  - 14
IP  - 1
DP  - 2017 Dec
TI  - Human in situ cytokine and leukocyte responses to acute smoking.
PG  - 109-115
LID - 10.1080/1547691X.2017.1332699 [doi]
AB  - This study examined immune/inflammatory parameters following an acute tobacco 
      smoking episode in smokers with varying smoking histories. Twenty-eight male 
      habitual smokers were categorized according to smoking history, e.g. younger 
      smoker (YSM) or middle-aged smoker (MSM). Participants were matched for fitness 
      and smoking habits and following baseline testing, undertook a smoking protocol 
      involving consumption of two cigarettes within 15 min. Venous blood was collected 
      pre- and immediately, 1 h, and 4 h post-protocol to permit analyses of 
      circulating levels of interleukin (IL)-6, IL-1beta, IL-1ra, monocyte chemoattractant 
      protein-1 (MCP-1), C-reactive protein (CRP), and leukocytes. No baseline 
      differences were observed between groups for IL-1ra, IL-1beta, or leukocytes. MCP-1 
      and IL-6 levels were significantly (p < 0.05) elevated at baseline in YSM. Both 
      groups showed an increase in MCP-1 levels from pre- to immediately post-cigarette 
      consumption. The MSM also displayed an increase in IL-6 post-smoking, followed by 
      a decline over the period from 1 to 4 h thereafter. A significant decline in 
      circulating lymphocyte and eosinophil levels from immediately post-cigarette 
      consumption to 1 h later was observed in both groups. Monocyte levels in the YSM 
      followed a similar profile but no significant effects on this cell type were 
      evident in the MSM. From these results, a 10-year difference in smoking history 
      induces mild leukopenia. Altered responses due to smoking were also evident with 
      respect to levels of circulating biomarkers, which may be indicative of an effect 
      of differences in cumulative smoking history.
FAU - Kastelein, Tegan
AU  - Kastelein T
AD  - a School of Exercise Science, Sport & Health , Charles Sturt University , 
      Bathurst , Australia.
FAU - Duffield, Rob
AU  - Duffield R
AD  - b Sport and Exercise Discipline Group , UTS: Health, University of Technology 
      Sydney (UTS) , Sydney , Australia.
FAU - Marino, Frank
AU  - Marino F
AD  - a School of Exercise Science, Sport & Health , Charles Sturt University , 
      Bathurst , Australia.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Immunotoxicol
JT  - Journal of immunotoxicology
JID - 101201960
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Biomarkers/*metabolism
MH  - C-Reactive Protein/metabolism
MH  - Cigarette Smoking/adverse effects/*immunology
MH  - Cytokines/*blood
MH  - Eosinophils/*immunology
MH  - Humans
MH  - Leukocytes, Mononuclear/*immunology
MH  - Leukopenia/etiology
MH  - Male
MH  - Smoking
MH  - Young Adult
OTO - NOTNLM
OT  - IL-6
OT  - MCP-1
OT  - Smokers
OT  - cigarette
OT  - cytokines
OT  - leukocytes
EDAT- 2017/05/28 06:00
MHDA- 2018/05/01 06:00
CRDT- 2017/05/28 06:00
PHST- 2017/05/28 06:00 [entrez]
PHST- 2017/05/28 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
AID - 10.1080/1547691X.2017.1332699 [doi]
PST - ppublish
SO  - J Immunotoxicol. 2017 Dec;14(1):109-115. doi: 10.1080/1547691X.2017.1332699.