PMID- 28550365 OWN - NLM STAT- MEDLINE DCOM- 20190304 LR - 20190304 IS - 1433-8491 (Electronic) IS - 0940-1334 (Linking) VI - 268 IP - 8 DP - 2018 Dec TI - A longitudinal study of neurotrophic, oxidative, and inflammatory markers in first-onset depression in midlife women. PG - 771-781 LID - 10.1007/s00406-017-0812-z [doi] AB - Prospective studies have shown during the years preceding and following menopause, also known as "menopause transition", that midlife women are at higher risk for developing first-onset major depressive disorder (MDD). The biological factors associated with risk and resilience in this population are, however, largely unknown. Considering the growing body of evidence suggesting that inflammation, oxidative stress, and brain-derived neurotrophic factor (BDNF) are associated with the pathophysiology of MDD, we investigated serum levels of protein carbonyl, lipid peroxidation (thiobarbituric acid reactive substances-TBARS), thiol group content, BDNF, 3-nitrotyrosine, and heat shock protein 70 (HSP70) in a longitudinal cohort of first-onset MDD. One hundred and forty-eight women from the Harvard Study of Moods and Cycles, a prospective study of midlife women monitored throughout the transition to menopause, were studied. Within- and between-groups analyses of these peripheral markers were conducted in 37 women who developed and 111 women that did not develop MDD during the 3-year follow-up period. In women who developed MDD, HSP70 and 3-nitrotyrosine were elevated at baseline, whereas TBARS were elevated 6 months prior to development of MDD, as compared to those who did not develop MDD. Within-group analyses showed that HSP70, 3-nitrotyrosine, and BDNF decreased over time, whereas protein carbonyl was elevated only at 12 months prior to development of MDD. In women who did not develop MDD, HSP70 and thiol decreased over time. The development of MDD in midlife women may be associated with a systemic cascade of pro-oxidative and pro-inflammatory events including increased HSP70, 3-nitrotyrosine, protein carbonyl, and lipid peroxidation and decreased BDNF. FAU - Pasquali, Matheus A AU - Pasquali MA AD - Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. AD - Mood Disorders Program, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. AD - Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. FAU - Harlow, Bernard L AU - Harlow BL AD - Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. FAU - Soares, Claudio N AU - Soares CN AD - Department of Psychiatry, Queen's University School of Medicine, Kingston, Canada. FAU - Otto, Michael W AU - Otto MW AD - Department of Psychological and Brain Sciences, Boston University, Boston, USA. FAU - Cohen, Lee S AU - Cohen LS AD - Center for Women's Mental Health, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. FAU - Minuzzi, Luciano AU - Minuzzi L AD - Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. AD - Mood Disorders Program, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. AD - Department of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th Street, Suite C124, Hamilton, ON, L8N 3K7, Canada. FAU - Gelain, Daniel P AU - Gelain DP AD - Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. FAU - Moreira, Jose Claudio F AU - Moreira JCF AD - Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. FAU - Frey, Benicio N AU - Frey BN AD - Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. freybn@mcmaster.ca. AD - Mood Disorders Program, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. freybn@mcmaster.ca. AD - Department of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th Street, Suite C124, Hamilton, ON, L8N 3K7, Canada. freybn@mcmaster.ca. LA - eng GR - R01-MH-50013 and R01-MH-69732/National Institute of Mental Health/ PT - Journal Article DEP - 20170526 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Cytokines) RN - 0 (HSP70 Heat-Shock Proteins) RN - 0 (Thiobarbituric Acid Reactive Substances) RN - 3604-79-3 (3-nitrotyrosine) RN - 42HK56048U (Tyrosine) SB - IM MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood MH - Cytokines/*blood MH - Depressive Disorder, Major/*blood/*complications MH - Female MH - HSP70 Heat-Shock Proteins/blood MH - Humans MH - Inflammation/*etiology MH - Lipid Peroxidation/physiology MH - Longitudinal Studies MH - Middle Aged MH - Oxidative Stress/*physiology MH - Protein Carbamylation/physiology MH - Psychiatric Status Rating Scales MH - Surveys and Questionnaires MH - Thiobarbituric Acid Reactive Substances/metabolism MH - Tyrosine/analogs & derivatives/blood OTO - NOTNLM OT - BDNF OT - Blood OT - Inflammation OT - Major depression OT - Menopause OT - Oxidative stress OT - Women EDAT- 2017/05/28 06:00 MHDA- 2019/03/05 06:00 CRDT- 2017/05/28 06:00 PHST- 2016/11/19 00:00 [received] PHST- 2017/05/19 00:00 [accepted] PHST- 2017/05/28 06:00 [pubmed] PHST- 2019/03/05 06:00 [medline] PHST- 2017/05/28 06:00 [entrez] AID - 10.1007/s00406-017-0812-z [pii] AID - 10.1007/s00406-017-0812-z [doi] PST - ppublish SO - Eur Arch Psychiatry Clin Neurosci. 2018 Dec;268(8):771-781. doi: 10.1007/s00406-017-0812-z. Epub 2017 May 26.