PMID- 28551754
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20211204
IS  - 0301-5556 (Print)
IS  - 0301-5556 (Linking)
VI  - 224
DP  - 2017
TI  - Neurotrophic Factors in Mouse Models of Autism Spectrum Disorder: Focus on BDNF 
      and IGF-1.
PG  - 121-134
LID - 10.1007/978-3-319-52498-6_7 [doi]
AB  - Neurotrophic factors are secreted proteins promoting the development and 
      maintaining the function of neural circuits. Studies in human individuals with 
      autism spectrum disorder (ASD) and corresponding animal models have implicated 
      that alterations of neurotrophic factor levels and the associated signalling 
      pathways might contribute to the underlying pathophysiology. As most of this work 
      has investigated the role of brain-derived neurotrophic factor (BDNF) and 
      insulin-like growth factor 1 (IGF-1) in ASD formation, we focus on these two 
      molecules in this review. We start with reviewing findings on neurotrophic factor 
      levels in human individuals with ASD, continue with providing a broad overview on 
      murine BDNF and IGF-1 in several well-established mouse models of ASD and finally 
      discuss the therapeutic potential of both molecules in the context of 
      translational ASD research.
FAU - Reim, Dominik
AU  - Reim D
AD  - Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.
AD  - International Graduate School in Molecular Medicine, Ulm University, Ulm, 
      Germany.
FAU - Schmeisser, Michael J
AU  - Schmeisser MJ
AD  - Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany. 
      michael.schmeisser@med.ovgu.de.
AD  - Division of Neuroanatomy, Institute of Anatomy, Otto-von-Guericke University, 
      Magdeburg, Germany. michael.schmeisser@med.ovgu.de.
AD  - Leibniz Institute for Neurobiology, Magdeburg, Germany. 
      michael.schmeisser@med.ovgu.de.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Adv Anat Embryol Cell Biol
JT  - Advances in anatomy, embryology, and cell biology
JID - 0407712
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Autism Spectrum Disorder/drug therapy/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism/therapeutic use
MH  - Disease Models, Animal
MH  - Humans
MH  - Insulin-Like Growth Factor I/*metabolism/therapeutic use
MH  - Mice
MH  - Translational Research, Biomedical
EDAT- 2017/05/30 06:00
MHDA- 2018/06/05 06:00
CRDT- 2017/05/29 06:00
PHST- 2017/05/29 06:00 [entrez]
PHST- 2017/05/30 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
AID - 10.1007/978-3-319-52498-6_7 [doi]
PST - ppublish
SO  - Adv Anat Embryol Cell Biol. 2017;224:121-134. doi: 10.1007/978-3-319-52498-6_7.