PMID- 28552072 OWN - NLM STAT- MEDLINE DCOM- 20190204 LR - 20190215 IS - 1875-6212 (Electronic) IS - 1570-1611 (Linking) VI - 16 IP - 4 DP - 2018 TI - Alterations in Plasma Triglyceride Concentrations Following Two Oral Meals with Different Fat Content in Patients with Type 2 Diabetes Mellitus. PG - 385-392 LID - 10.2174/1570161115666170529084621 [doi] AB - BACKGROUND: Enhanced postprandial lipaemia has been reported in patients with obesity, hypertension, metabolic syndrome and type 2 diabetes mellitus (T2DM). We compared 2 oral fat meal tests (LIPOLD: 149g of fat, 56g of carbohydrates and 11.7g of proteins administrated per 2m2 of body surface) and LIPOTEST: 75g of fat, 25g of carbohydrates and 10g of protein with the addition of 15g common sugar) with regard to changes in triglycerides (TGs) as well as other cardiometabolic parameters between baseline and 4 h after the meals. METHODS: We studied 21 men [median age (interquartile range; IQR) = 65 (16) years] with well-controlled T2DM [median glycated haemoglobin (HbA1c) (IQR) = 6.6 (0.9) %]. All participants performed the meals with 1 week interval between the 2 meals. RESULTS: Median (IQR) TG differences in mg/dl were 86 (100) and 46 (60) for LIPOLD and LIPOTEST meals, respectively, whereas the % differences in TGs were 105 (105) and 48 (55), respectively. The differences (in mg/dl and %) between TGs before ingesting the test meal and after 4h were significant for both LIPOLD and LIPOTEST meals (p = 0.003 for mg/dl differences and p = 0.005 for % differences). Patients who had a positive response to the LIPOLD meal (i.e. TGs > 220 mg/dl at 4 h) also had increased postprandial TGs with LIPOTEST. The Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) correlated with TG differences (in mg/dl) following the LIPOLD meal consumption (Spearman's rho = (+) 0.527, p = 0.02). C-peptide correlated with TG differences (in mg/dl) following the LIPOTEST meal consumption (Spearman's rho = (+) 0.538, p = 0.032). There were no differences in TGs and glucose response postprandially in both testing meals according to body mass index (except for TGs between tertile 21.3-24.5 and 25-26.8 kg/m2, p=0.046, in LPOTEST group) and body surface area. CONCLUSION: An oral fat tolerance test (OFTT), which contains 75g fat, and represents the everyday habits of Western societies, could provide additional information regarding the postprandial state of the individuals with well-controlled T2DM. The consumption of meals with very high fat content may lead to over diagnosing PPL. TG differences after the consumption of a high fat meal correlated with HOMA-IR. This may be useful to evaluate the role of HOMA-IR in T2DM patients. A standardized the OFTT will help clinicians to better define postprandial TG abnormalities, leading to more appropriate therapeutic options to improve postprandial dysmetabolism. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.org. FAU - Gavra, Paraskevi AU - Gavra P AD - Diabetes Mellitus Department, Tzanio General Hospital, Athens, Greece. FAU - Melidonis, Andreas AU - Melidonis A AD - Diabetes Mellitus Department, Tzanio General Hospital, Athens, Greece. FAU - Iraklianou, Stella AU - Iraklianou S AD - Diabetes Mellitus Department, Tzanio General Hospital, Athens, Greece. FAU - Mihas, Constantinos AU - Mihas C AD - Internal Medicine Department, Kimi General Hospital, Kimi, Greece. FAU - Kolovou, Vana AU - Kolovou V AD - Cardiology Department, Onassis Cardiac Surgery Centre, Athens, Greece. FAU - Mavrogeni, Sophie AU - Mavrogeni S AD - Cardiology Department, Onassis Cardiac Surgery Centre, Athens, Greece. FAU - Dimitriadis, George AU - Dimitriadis G AD - 2nd Department of Internal Medicine, Research Institute and Diabetes Centre, "Attikon" University General Hospital, Athens University Medical School, GR 12462 Haidari, Greece. FAU - Rallidis, Loukianos AU - Rallidis L AD - 2nd University Cardiology Department, "Attikon" General Hospital, Athens, Greece. FAU - Vasaramva, Kaliopi AU - Vasaramva K AD - Diabetes Mellitus Department, Tzanio General Hospital, Athens, Greece. FAU - Boutati, Eleni AU - Boutati E AD - 2nd Department of Internal Medicine, Research Institute and Diabetes Centre, "Attikon" University General Hospital, Athens University Medical School, GR 12462 Haidari, Greece. FAU - Katsiki, Niki AU - Katsiki N AD - 2nd Propaedeutic Department of Internal Medicine, Hippokration University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Kolovou, Genovefa AU - Kolovou G AD - Cardiology Department, Onassis Cardiac Surgery Centre, Athens, Greece. LA - eng PT - Comparative Study PT - Journal Article PL - United Arab Emirates TA - Curr Vasc Pharmacol JT - Current vascular pharmacology JID - 101157208 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - 0 (Dietary Fats) RN - 0 (Insulin) RN - 0 (Triglycerides) SB - IM MH - Aged MH - Biomarkers/blood MH - Blood Glucose/metabolism MH - Diabetes Mellitus, Type 2/*blood/diagnosis/physiopathology MH - Dietary Fats/*administration & dosage/adverse effects/metabolism MH - Dyslipidemias/*blood/diagnosis/physiopathology MH - Humans MH - Insulin/blood MH - Insulin Resistance MH - Male MH - *Meals MH - Middle Aged MH - Postprandial Period MH - Time Factors MH - Triglycerides/*blood OTO - NOTNLM OT - CHD OT - LIPOLD meal OT - LIPOTEST meal OT - Type 2 diabetes mellitus OT - homeostasis model assessment of insulin resistance OT - postprandial hypertriglyceridemia. EDAT- 2017/05/30 06:00 MHDA- 2019/02/05 06:00 CRDT- 2017/05/30 06:00 PHST- 2017/04/22 00:00 [received] PHST- 2017/05/09 00:00 [revised] PHST- 2017/05/17 00:00 [accepted] PHST- 2017/05/30 06:00 [pubmed] PHST- 2019/02/05 06:00 [medline] PHST- 2017/05/30 06:00 [entrez] AID - CVP-EPUB-83711 [pii] AID - 10.2174/1570161115666170529084621 [doi] PST - ppublish SO - Curr Vasc Pharmacol. 2018;16(4):385-392. doi: 10.2174/1570161115666170529084621.