PMID- 28553112
OWN - NLM
STAT- MEDLINE
DCOM- 20170904
LR  - 20220321
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 12
DP  - 2017
TI  - IONP-doped nanoparticles for highly effective NIR-controlled drug release and 
      combination tumor therapy.
PG  - 3751-3766
LID - 10.2147/IJN.S113963 [doi]
AB  - Despite advances in controlled drug delivery, drug delivery systems (DDSs) with 
      controlled activated drug release and high spatial and temporal resolution are 
      still required. Theranostic nanomedicine is capable of diagnosis, therapy, and 
      monitoring the delivery and distribution of drug molecules and has received 
      growing interest. In this study, a near-infrared light-controlled "off-on" DDS 
      with magnetic resonance imaging and magnetic targeting properties was developed 
      using a hybrid nanoplatform (carbon nanotubes [CNTs]-iron oxide nanoparticle). 
      Doxorubicin (DOX) and distearoyl-sn-glycero-3-phosphoethanolamine-PEG were 
      adsorbed onto CNTs-iron oxide nanoparticle, and then to avoid the unexpected drug 
      release during circulation, 1-myristyl alcohol was used to encapsulate the 
      CNTs-drug complex. Herein, multifunctional DOX-loaded nanoparticles (NPs) with 
      "off-on" state were developed. DOX-NPs showed an obvious "off-on" effect 
      (temperature increase, drug release) controlled by near-infrared light in vitro 
      and in vivo. In the in vivo and in vitro studies, DOX-NPs exhibited excellent 
      magnetic resonance imaging ability, magnetic targeting property, high biosafety, 
      and high antitumor combined therapeutic efficacy (hyperthermia combined with 
      chemotherapy). These results highlight the great potential of DOX-NPs in the 
      treatment of cancer.
FAU - Fu, Xudong
AU  - Fu X
AD  - The Fifth Affiliated Hospital of Zhengzhou University.
FAU - Wang, Xinjun
AU  - Wang X
AD  - The Fifth Affiliated Hospital of Zhengzhou University.
FAU - Zhou, Shaolong
AU  - Zhou S
AD  - The Fifth Affiliated Hospital of Zhengzhou University.
FAU - Zhang, Yanyan
AU  - Zhang Y
AD  - School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20170516
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 0 (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 
      2000))
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Ferric Compounds)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Phosphatidylethanolamines)
RN  - 1K09F3G675 (ferric oxide)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Antibiotics, Antineoplastic/*administration & dosage/chemistry/pharmacokinetics
MH  - Cell Line, Tumor
MH  - Delayed-Action Preparations
MH  - Doxorubicin/administration & dosage/chemistry/*pharmacokinetics
MH  - Drug Delivery Systems/*methods
MH  - Drug Liberation
MH  - Female
MH  - Ferric Compounds/chemistry
MH  - Magnetic Resonance Imaging
MH  - Magnetite Nanoparticles/administration & dosage/*chemistry
MH  - Mice, Inbred BALB C
MH  - Microscopy, Electron, Transmission
MH  - Nanotubes, Carbon/*chemistry
MH  - Neoplasms, Experimental/diagnostic imaging/drug therapy
MH  - Phosphatidylethanolamines/chemistry
MH  - Polyethylene Glycols/chemistry
MH  - Theranostic Nanomedicine/instrumentation/methods
MH  - Xenograft Model Antitumor Assays
PMC - PMC5440031
OTO - NOTNLM
OT  - MRI
OT  - combination therapy
OT  - controlled drug release
OT  - magnetic targeting
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/05/30 06:00
MHDA- 2017/09/05 06:00
PMCR- 2017/05/16
CRDT- 2017/05/30 06:00
PHST- 2017/05/30 06:00 [entrez]
PHST- 2017/05/30 06:00 [pubmed]
PHST- 2017/09/05 06:00 [medline]
PHST- 2017/05/16 00:00 [pmc-release]
AID - ijn-12-3751 [pii]
AID - 10.2147/IJN.S113963 [doi]
PST - epublish
SO  - Int J Nanomedicine. 2017 May 16;12:3751-3766. doi: 10.2147/IJN.S113963. 
      eCollection 2017.