PMID- 28553646
OWN - NLM
STAT- MEDLINE
DCOM- 20180301
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - Protection against Blast-Induced Traumatic Brain Injury by Increase in Brain 
      Volume.
PG  - 2075463
LID - 10.1155/2017/2075463 [doi]
LID - 2075463
AB  - Blast-induced traumatic brain injury (bTBI) is a leading cause of injuries in 
      recent military conflicts and it is responsible for an increased number of 
      civilian casualties by terrorist attacks. bTBI includes a variety of 
      neuropathological changes depending on the intensity of blast overpressure (BOP) 
      such as brain edema, neuronal degeneration, diffuse axonal damage, and vascular 
      dysfunction with neurological manifestations of psychological and cognitive 
      abnormalities. Internal jugular vein (IJV) compression is known to reduce 
      intracranial compliance by causing an increase in brain volume and was shown to 
      reduce brain damage during closed impact-induced TBI. We investigated whether IJV 
      compression can attenuate signs of TBI in rats after exposure to BOP. Animals 
      were exposed to three 110 +/- 5 kPa BOPs separated by 30 min intervals. Exposure to 
      BOP resulted in a significant decrease of neuronal nuclei (NeuN) together with 
      upregulation of aquaporin-4 (AQP-4), 3-nitrotyrosine (3-NT), and endothelin 1 
      receptor A (ETRA) expression in frontal cortex and hippocampus one day following 
      exposures. IJV compression attenuated this BOP-induced increase in 3-NT in cortex 
      and ameliorated the upregulation of AQP-4 in hippocampus. These results suggest 
      that elevated intracranial pressure and intracerebral volume have neuroprotective 
      potential in blast-induced TBI.
FAU - Gu, Ming
AU  - Gu M
AUID- ORCID: 0000-0003-2053-6817
AD  - NeuroTrauma Department, Naval Medical Research Center, Silver Spring, MD, USA.
FAU - Kawoos, Usmah
AU  - Kawoos U
AD  - NeuroTrauma Department, Naval Medical Research Center, Silver Spring, MD, USA.
FAU - McCarron, Richard
AU  - McCarron R
AD  - NeuroTrauma Department, Naval Medical Research Center, Silver Spring, MD, USA.
AD  - Department of Surgery, Uniformed Services University of the Health Sciences and 
      the Walter Reed National Military Medical Center, Bethesda, MD, USA.
FAU - Chavko, Mikulas
AU  - Chavko M
AD  - NeuroTrauma Department, Naval Medical Research Center, Silver Spring, MD, USA.
LA  - eng
PT  - Journal Article
DEP - 20170410
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Animals
MH  - Blast Injuries/complications/metabolism/physiopathology/*therapy
MH  - Brain Injuries, Traumatic/metabolism/physiopathology/*prevention & control
MH  - Frontal Lobe/metabolism/pathology/*physiopathology
MH  - Hippocampus/metabolism/pathology/*physiopathology
MH  - Humans
MH  - *Intracranial Pressure
MH  - Male
MH  - Organ Size
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC5434276
EDAT- 2017/05/30 06:00
MHDA- 2018/03/02 06:00
PMCR- 2017/04/10
CRDT- 2017/05/30 06:00
PHST- 2016/12/12 00:00 [received]
PHST- 2017/02/13 00:00 [revised]
PHST- 2017/03/23 00:00 [accepted]
PHST- 2017/05/30 06:00 [entrez]
PHST- 2017/05/30 06:00 [pubmed]
PHST- 2018/03/02 06:00 [medline]
PHST- 2017/04/10 00:00 [pmc-release]
AID - 10.1155/2017/2075463 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:2075463. doi: 10.1155/2017/2075463. Epub 2017 Apr 10.