PMID- 28553680
OWN - NLM
STAT- MEDLINE
DCOM- 20180822
LR  - 20221207
IS  - 1437-7799 (Electronic)
IS  - 1342-1751 (Linking)
VI  - 22
IP  - 1
DP  - 2018 Feb
TI  - The choice of comorbidity scoring system in Chinese peritoneal dialysis patients.
PG  - 159-166
LID - 10.1007/s10157-017-1418-5 [doi]
AB  - BACKGROUND: Several comorbidity scoring systems have been developed and 
      validated, mostly in western hemodialysis patients with a high risk of 
      cardiovascular disease. The performance of comorbidity scoring, however, depends 
      on the patient population. In this study, we determine the optimal comorbidity 
      scoring system for predicting survival of incident Chinese PD patients. METHODS: 
      We studied 461 incident PD patients. The performance of Charlson Comorbidity 
      Index (CCI), Hemmelgarn score, and Liu score as the survival predictor was 
      compared. RESULTS: The mean age was 57.7 +/- 13.7 years. The median CCI, 
      Hemmelgarn, and Liu scores were 4 [inter-quartile range (IQR) 2-5], 1 (IQR 0-2), 
      and 4 (IQR 2-5), respectively. Patients were followed for 45.5 +/- 33.0 months. All 
      3 comorbidity scores were predictors of patient survival by univariate analysis. 
      After adjusting for confounding factors, CCI was the best predictor of patient 
      survival among the 3 indices, with each point increase in CCI conferring 31% 
      excess in mortality risk [95% confidence interval (CI) 21-41%, p < 0.001]. In 
      contrast, each point increase in Liu score confers 20% excess in mortality risk 
      (95% CI 13-27%, p < 0.001). Although the Hemmelgarn score is an independent 
      predictor of patient survival, over 70% of patients score 0 or 1 by this system, 
      limiting its role as a prognostic marker. CONCLUSION: CCI should be the preferred 
      method for quantifying comorbidity load in incident Chinese PD patients, and it 
      is a good predictor of survival in this group of patients.
FAU - Ma, Terry King-Wing
AU  - Ma TK
AD  - Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine 
      and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 
      Shatin, Hong Kong SAR, China.
FAU - Chow, Kai Ming
AU  - Chow KM
AD  - Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine 
      and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 
      Shatin, Hong Kong SAR, China.
FAU - Kwan, Bonnie Ching-Ha
AU  - Kwan BC
AD  - Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine 
      and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 
      Shatin, Hong Kong SAR, China.
FAU - Ng, Jack Kit-Chung
AU  - Ng JK
AD  - Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine 
      and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 
      Shatin, Hong Kong SAR, China.
FAU - Pang, Wing-Fai
AU  - Pang WF
AD  - Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine 
      and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 
      Shatin, Hong Kong SAR, China.
FAU - Leung, Chi Bon
AU  - Leung CB
AD  - Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine 
      and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 
      Shatin, Hong Kong SAR, China.
FAU - Li, Philip Kam-To
AU  - Li PK
AD  - Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine 
      and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 
      Shatin, Hong Kong SAR, China.
FAU - Szeto, Cheuk Chun
AU  - Szeto CC
AD  - Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine 
      and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 
      Shatin, Hong Kong SAR, China. ccszeto@cuhk.edu.hk.
LA  - eng
GR  - research accounts 6901031/Chinese University of Hong Kong (HK)/
PT  - Journal Article
DEP - 20170529
PL  - Japan
TA  - Clin Exp Nephrol
JT  - Clinical and experimental nephrology
JID - 9709923
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - *Comorbidity
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Nutritional Status
MH  - *Peritoneal Dialysis
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Renal Insufficiency, Chronic/*epidemiology/*therapy
MH  - Severity of Illness Index
MH  - Survival Analysis
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Renal failure
OT  - Survival
EDAT- 2017/05/30 06:00
MHDA- 2018/08/23 06:00
CRDT- 2017/05/30 06:00
PHST- 2017/03/16 00:00 [received]
PHST- 2017/05/08 00:00 [accepted]
PHST- 2017/05/30 06:00 [pubmed]
PHST- 2018/08/23 06:00 [medline]
PHST- 2017/05/30 06:00 [entrez]
AID - 10.1007/s10157-017-1418-5 [pii]
AID - 10.1007/s10157-017-1418-5 [doi]
PST - ppublish
SO  - Clin Exp Nephrol. 2018 Feb;22(1):159-166. doi: 10.1007/s10157-017-1418-5. Epub 
      2017 May 29.