PMID- 28554197
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1976-9148 (Print)
IS  - 2005-4483 (Electronic)
IS  - 1976-9148 (Linking)
VI  - 25
IP  - 5
DP  - 2017 Sep 1
TI  - A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays 
      the Progress of Neuronal Cell Death by Inhibiting Microglial Activation.
PG  - 519-527
LID - 10.4062/biomolther.2016.224 [doi]
AB  - Excessive activation of microglia causes the continuous production of neurotoxic 
      mediators, which further causes neuron degeneration. Therefore, inhibition of 
      microglial activation is a possible target for the treatment of neurodegenerative 
      disorders. Balanophonin, a natural neolignoid from Firmiana simplex, has been 
      reported to have anti-inflammatory and anti-cancer effects. In this study, we 
      aimed to evaluate the anti-neuroinflammatory effects and mechanism of 
      balanophonin in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. BV2 
      microglia cells were stimulated with LPS in the presence or absence of 
      balanophonin. The results indicated that balanophonin reduced not only the 
      LPS-mediated TLR4 activation but also the production of inflammatory mediators, 
      such as nitric oxide (NO), prostaglandin E2 (PGE2), Interleukin-1beta (IL-1beta), and 
      tumor necrosis factor-alpha (TNF-alpha), in BV2 cells. Balanophonin also inhibited 
      LPS-induced inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX2) 
      protein expression and mitogen activated protein kinases (MAPKs), including 
      extracellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK), 
      and p38 MAPK. Interestingly, it also inhibited neuronal cell death resulting from 
      LPS-activated microglia by regulating cleaved caspase-3 and poly ADP ribose 
      polymerase (PARP) cleavage in N2a cells. In conclusion, our data indicated that 
      balanophonin may delay the progression of neuronal cell death by inhibiting 
      microglial activation.
FAU - Lim, Soo Young
AU  - Lim SY
AD  - College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
AD  - Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, 
      Republic of Korea.
FAU - Subedi, Lalita
AU  - Subedi L
AD  - College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
AD  - Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, 
      Republic of Korea.
FAU - Shin, Dongyun
AU  - Shin D
AD  - College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
AD  - Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, 
      Republic of Korea.
FAU - Kim, Chung Sub
AU  - Kim CS
AD  - Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 
      16419, Republic of Korea.
FAU - Lee, Kang Ro
AU  - Lee KR
AD  - Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 
      16419, Republic of Korea.
FAU - Kim, Sun Yeou
AU  - Kim SY
AD  - College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
AD  - Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, 
      Republic of Korea.
AD  - Gachon Medical Research Institute, Gil Medical Center, Incheon 21565, Republic of 
      Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Biomol Ther (Seoul)
JT  - Biomolecules & therapeutics
JID - 101472832
PMC - PMC5590796
OTO - NOTNLM
OT  - Apoptosis
OT  - Balanophonin
OT  - Firmiana simplex
OT  - Microglia
OT  - Neuroinflammation
OT  - Neuroprotection
EDAT- 2017/05/31 06:00
MHDA- 2017/05/31 06:01
PMCR- 2017/09/01
CRDT- 2017/05/31 06:00
PHST- 2016/09/30 00:00 [received]
PHST- 2017/01/17 00:00 [revised]
PHST- 2017/02/20 00:00 [accepted]
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2017/05/31 06:01 [medline]
PHST- 2017/05/31 06:00 [entrez]
PHST- 2017/09/01 00:00 [pmc-release]
AID - biomolther.2016.224 [pii]
AID - bt-25-519 [pii]
AID - 10.4062/biomolther.2016.224 [doi]
PST - ppublish
SO  - Biomol Ther (Seoul). 2017 Sep 1;25(5):519-527. doi: 10.4062/biomolther.2016.224.