PMID- 28554528
OWN - NLM
STAT- MEDLINE
DCOM- 20180227
LR  - 20180329
IS  - 1873-6823 (Electronic)
IS  - 0741-8329 (Linking)
VI  - 61
DP  - 2017 Jun
TI  - Lobeline attenuates ethanol abstinence-induced depression-like behavior in mice.
PG  - 63-70
LID - S0741-8329(16)30226-9 [pii]
LID - 10.1016/j.alcohol.2017.01.015 [doi]
AB  - Evidence indicates that the brain nicotinic acetylcholine receptor (nAChRs) 
      ligand lobeline reduces depression-like behaviors, ethanol drinking, and nicotine 
      withdrawal-induced depression-like behaviors. The purpose of the present study 
      was to determine the effects of lobeline on ethanol abstinence-induced 
      depression-like behavior and associated neuroadaptive changes in mice. Adult 
      C57BL/6J male mice were allowed to drink 10% ethanol for 4 weeks using a 
      two-bottle choice procedure. Mice were tested after 24 h and 14 days of ethanol 
      abstinence in a forced swim test (FST), a measure for depression-like behavior. 
      Acute lobeline treatment (1 mg/kg) significantly reduced immobility time compared 
      to controls after 24 h and 14 days of abstinence. In addition, abstinence from 
      chronic ethanol exposure reduced serotonin levels in the hippocampus, which was 
      reversed by acute lobeline treatment. Repeated lobeline treatment (1 mg/kg, once 
      daily) for 14 days during ethanol abstinence also significantly reduced FST 
      immobility in mice exposed to ethanol. Chronic ethanol exposure significantly 
      reduced the number of 5-bromo 2'-deoxyuridine (BrdU)-positive cells in the 
      dentate gyrus of the hippocampus, indicating decreased hippocampal cell 
      proliferation. Abstinence from chronic ethanol exposure also decreased 
      brain-derived neurotrophic factor (BDNF) in the dentate gyrus and CA3 region of 
      the hippocampus. In contrast, repeated lobeline treatment significantly increased 
      both BrdU- and BDNF-positive cells. Taken together, our results indicate that 
      lobeline produced antidepressant-like effects, likely by targeting brain 
      beta2-containing nAChRs, serotonergic neurotransmission, and/or hippocampal cell 
      proliferation. Therefore, lobeline may have therapeutic utility to treat alcohol 
      abstinence-induced depression.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Roni, Monzurul Amin
AU  - Roni MA
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State 
      University, Brookings, SD 57007, USA.
FAU - Rahman, Shafiqur
AU  - Rahman S
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State 
      University, Brookings, SD 57007, USA. Electronic address: 
      shafiqur.rahman@sdstate.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170526
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 333DO1RDJY (Serotonin)
RN  - 3K9958V90M (Ethanol)
RN  - D0P25S3P81 (Lobeline)
SB  - IM
MH  - Alcohol Abstinence/*psychology
MH  - Alcohol Drinking/physiopathology
MH  - Animals
MH  - Antidepressive Agents
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Cell Proliferation/drug effects
MH  - Depression/*drug therapy/*etiology
MH  - Ethanol/administration & dosage
MH  - Hippocampus/chemistry/cytology/drug effects
MH  - Lobeline/*therapeutic use
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Serotonin/analysis
MH  - Swimming
OTO - NOTNLM
OT  - Alcohol
OT  - Hippocampus
OT  - Lobeline
OT  - Major depression
OT  - Mice
OT  - Nicotinic receptor
EDAT- 2017/05/31 06:00
MHDA- 2018/02/28 06:00
CRDT- 2017/05/31 06:00
PHST- 2016/09/06 00:00 [received]
PHST- 2016/12/29 00:00 [revised]
PHST- 2017/01/30 00:00 [accepted]
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2018/02/28 06:00 [medline]
PHST- 2017/05/31 06:00 [entrez]
AID - S0741-8329(16)30226-9 [pii]
AID - 10.1016/j.alcohol.2017.01.015 [doi]
PST - ppublish
SO  - Alcohol. 2017 Jun;61:63-70. doi: 10.1016/j.alcohol.2017.01.015. Epub 2017 May 26.