PMID- 28554653
OWN - NLM
STAT- MEDLINE
DCOM- 20180313
LR  - 20191210
IS  - 1096-1208 (Electronic)
IS  - 0882-4010 (Linking)
VI  - 109
DP  - 2017 Aug
TI  - Dendritic cells during mousepox: The role of delayed apoptosis in the 
      pathogenesis of infection.
PG  - 99-109
LID - S0882-4010(16)30584-8 [pii]
LID - 10.1016/j.micpath.2017.05.037 [doi]
AB  - Dendritic cells (DCs) are effector cells linking the innate immune system with 
      the adaptive immune response. Many viruses eliminate DCs to prevent host 
      response, induce immunosuppression and to maintain chronic infection. In this 
      study, we examined apoptotic response of dendritic cells during in vitro and 
      in vivo infection with ectromelia virus (ECTV), the causative agent of mousepox. 
      ECTV-infected bone marrow dendritic cells (BMDCs) from BALB/c mice underwent 
      apoptosis through mitochondrial pathway at 48 h post infection, up-regulated FasL 
      and decreased expression of anti-apoptotic Bcl-2 and pro-apoptotic Fas. Similar 
      pattern of Bcl-2, Fas and FasL expression was observed for DCs early during 
      in vivo infection of BALB/c mice. Both BMDCs and DCs from BALB/c mice showed no 
      maturation upon ECTV infection. We conclude that ECTV-infected DCs from BALB/c 
      mouse strain help the virus to spread and to maintain infection.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Orlowski, Piotr
AU  - Orlowski P
AD  - Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, 
      Poland. Electronic address: piotr.r.orlowski@gmail.com.
FAU - Pardecka, Maja
AU  - Pardecka M
AD  - Department of Preclinical Sciences, Faculty of Veterinary Medicine, Ciszewskiego 
      8, 02-786, Warsaw University of Life Sciences, Warsaw, Poland.
FAU - Cymerys, Joanna
AU  - Cymerys J
AD  - Department of Preclinical Sciences, Faculty of Veterinary Medicine, Ciszewskiego 
      8, 02-786, Warsaw University of Life Sciences, Warsaw, Poland.
FAU - Krzyzowska, Malgorzata
AU  - Krzyzowska M
AD  - Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, 
      Poland.
LA  - eng
PT  - Journal Article
DEP - 20170526
PL  - England
TA  - Microb Pathog
JT  - Microbial pathogenesis
JID - 8606191
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Fas Ligand Protein)
RN  - 0 (Fasl protein, mouse)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - EC 3.4.22.- (Casp3 protein, mouse)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - *Apoptosis
MH  - Apoptosis Regulatory Proteins/metabolism
MH  - Caspase 3
MH  - Chlorocebus aethiops
MH  - Dendritic Cells/*immunology/pathology/physiology/virology
MH  - Disease Models, Animal
MH  - Ectromelia virus/*pathogenicity/*physiology
MH  - Ectromelia, Infectious/*immunology/virology
MH  - Fas Ligand Protein/metabolism
MH  - Gene Expression Regulation
MH  - Immunity, Innate
MH  - Immunohistochemistry
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mitochondria/metabolism
MH  - Proto-Oncogene Proteins c-bcl-2/metabolism
MH  - Signal Transduction
MH  - Up-Regulation
MH  - Vero Cells
OTO - NOTNLM
OT  - Dendritic cells
OT  - Ectromelia virus
OT  - Fas/FasL
EDAT- 2017/05/31 06:00
MHDA- 2018/03/14 06:00
CRDT- 2017/05/31 06:00
PHST- 2016/09/26 00:00 [received]
PHST- 2017/05/14 00:00 [revised]
PHST- 2017/05/19 00:00 [accepted]
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2018/03/14 06:00 [medline]
PHST- 2017/05/31 06:00 [entrez]
AID - S0882-4010(16)30584-8 [pii]
AID - 10.1016/j.micpath.2017.05.037 [doi]
PST - ppublish
SO  - Microb Pathog. 2017 Aug;109:99-109. doi: 10.1016/j.micpath.2017.05.037. Epub 2017 
      May 26.