PMID- 28554990
OWN - NLM
STAT- MEDLINE
DCOM- 20190429
LR  - 20201209
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 18
IP  - 2
DP  - 2017 Aug
TI  - The role of SCUBE1 in the pathogenesis of no-reflow phenomenon presenting with ST 
      segment elevation myocardial infarction.
PG  - 122-127
LID - 10.14744/AnatolJCardiol.2017.7705 [doi]
AB  - OBJECTIVE: SCUBE1 [signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth 
      factor)-like domain-containing protein 1] might function as a novel 
      platelet-endothelial adhesion molecule and play pathological roles in 
      cardiovascular biology. Acute myocardial infarction is one of the most common 
      causes of death in modern society. The concept of "no reflow" (NR) refers to a 
      state of myocardial tissue hypoperfusion in the presence of a patent epicardial 
      coronary artery. The main mechanisms of this phenomenon are thought to be high 
      platelet activity and much thrombus burden. So, we researched the role of SCUBE1 
      in the pathogenesis of NR. METHODS: A total of 142 patients with ST elevation 
      myocardial infarction (STEMI) (n=42 with NR and n=100 without NR) and 50 healthy 
      individuals were prospectively case-control recruited between March 2015 and 
      October 2016 from our outpatient clinics of cardiology department. Patients with 
      STEMI were diagnosed according to American Heart Association (AHA) guideline for 
      the management of STEMI. RESULTS: The mean SCUBE1 levels of the control subjects 
      were 34+/-8.4 ng/mL, the mean SCUBE1 levels of patients with STEMI who were treated 
      successfully with primary percutaneous coronary intervention (PCI) were 51+/-6.2, 
      and the mean SCUBE1 levels of patients with STEMI who had NR phenomenon after 
      primary PCI procedure were 97.2+/-8.9 ng/mL. CONCLUSION: In our opinion, SCUBE1 
      might contribute to NR phenomenon via thrombus activation and aggregation. The 
      pathophysiology of NR phenomenon is unclear. The present study is the first 
      clinical study that demonstrated that serum SCUBE1 level was significantly higher 
      in patients with NR and that serum SCUBE1 was an independent predictor for the 
      presence of NR in our study population.
FAU - Bolayir, Hasan Ata
AU  - Bolayir HA
AD  - Department Cardiology, Sivas Numune Hospital; Sivas-Turkey. 
      habolayir@hotmail.com.
FAU - Gunes, Hakan
AU  - Gunes H
FAU - Kivrak, Tarik
AU  - Kivrak T
FAU - Sahin, Omer
AU  - Sahin O
FAU - Akaslan, Dursun
AU  - Akaslan D
FAU - Kurt, Recep
AU  - Kurt R
FAU - Bolayir, Asli
AU  - Bolayir A
FAU - Imadoglu, Oya
AU  - Imadoglu O
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20170524
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
RN  - 0 (Biomarkers)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (SCUBE1 protein, human)
SB  - IM
MH  - Biomarkers/*blood
MH  - Calcium-Binding Proteins
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Membrane Proteins/*blood
MH  - Middle Aged
MH  - No-Reflow Phenomenon/blood/*physiopathology/surgery
MH  - Percutaneous Coronary Intervention
MH  - Prospective Studies
MH  - ROC Curve
MH  - ST Elevation Myocardial Infarction/blood/*physiopathology/surgery
MH  - Sensitivity and Specificity
MH  - Stents
PMC - PMC5731261
COIS- Conflict of interest: None declared.
EDAT- 2017/05/31 06:00
MHDA- 2019/04/30 06:00
PMCR- 2017/08/01
CRDT- 2017/05/31 06:00
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2019/04/30 06:00 [medline]
PHST- 2017/05/31 06:00 [entrez]
PHST- 2017/08/01 00:00 [pmc-release]
AID - AJC-18-122 [pii]
AID - 10.14744/AnatolJCardiol.2017.7705 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2017 Aug;18(2):122-127. doi: 10.14744/AnatolJCardiol.2017.7705. 
      Epub 2017 May 24.