PMID- 28555329
OWN - NLM
STAT- MEDLINE
DCOM- 20171003
LR  - 20220330
IS  - 1534-6315 (Electronic)
IS  - 1529-7322 (Linking)
VI  - 17
IP  - 7
DP  - 2017 Jul
TI  - T Cells in Allergic Asthma: Key Players Beyond the Th2 Pathway.
PG  - 43
LID - 10.1007/s11882-017-0714-1 [doi]
AB  - Asthma is a common chronic lung disease that affects 300 million people 
      worldwide. It causes the airways of the lungs to swell and narrow due to 
      inflammation (swelling and excess mucus build-up in the airways) and airway 
      constriction (tightening of the muscles surrounding the airways). Atopic asthma 
      is the most common form of asthma, and is triggered by inhaled allergens that 
      ultimately promote the activation of the Th2-like T cells and the development of 
      Th2-mediated chronic inflammation. Different subsets of T cells, including T 
      follicular helper cells, tissue-resident T, cells and Th2 effector cells, play 
      different functions during allergic immune response. Dendritic cells (DCs) are 
      known to play a central role in initiating allergic Th2-type immune responses and 
      in the development of the T cell phenotype. However, this function depends on the 
      complex interaction with other cells of the immune system and determines whether 
      the response to environmental allergens will be one of tolerance or allergic 
      inflammation. This review discusses cell interactions leading to the initiation 
      and maintenance of allergic Th2-type immune responses, particularly those 
      associated with allergic asthma.
FAU - Leomicronn, Beatriz
AU  - Leomicronn B
AD  - Department of Microbiology, University of Alabama at Birmingham, 1825 University 
      Blvd, SHEL 406, Birmingham, AL, 35294, USA. bleon@uab.edu.
LA  - eng
GR  - R01 AI116584/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Asthma/*immunology
MH  - B-Lymphocytes/immunology
MH  - Dendritic Cells/immunology
MH  - Epithelial Cells/immunology
MH  - Humans
MH  - Lung/immunology
MH  - T-Lymphocytes/*immunology
OTO - NOTNLM
OT  - B cells
OT  - Dendritic cells
OT  - Epithelial cells
OT  - T follicular helper cells
OT  - Th2-driven allergic asthma
OT  - Tissue-resident T cells
EDAT- 2017/05/31 06:00
MHDA- 2017/10/04 06:00
CRDT- 2017/05/31 06:00
PHST- 2017/05/31 06:00 [entrez]
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2017/10/04 06:00 [medline]
AID - 10.1007/s11882-017-0714-1 [pii]
AID - 10.1007/s11882-017-0714-1 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2017 Jul;17(7):43. doi: 10.1007/s11882-017-0714-1.