PMID- 28555373
OWN - NLM
STAT- MEDLINE
DCOM- 20180629
LR  - 20210108
IS  - 1557-1904 (Electronic)
IS  - 1557-1890 (Print)
IS  - 1557-1890 (Linking)
VI  - 12
IP  - 4
DP  - 2017 Dec
TI  - Blood Brain Barrier Injury in Diabetes: Unrecognized Effects on Brain and 
      Cognition.
PG  - 593-601
LID - 10.1007/s11481-017-9752-7 [doi]
AB  - Diabetes mellitus (DM) is a disorder due to the inability properly to metabolize 
      glucose associated with dysregulation of metabolic pathways of lipids and 
      proteins resulting in structural and functional changes of various organ systems. 
      DM has detrimental effects on the vasculature, resulting in the development of 
      various cardiovascular diseases and stemming from microvascular injury. The blood 
      brain barrier (BBB) is a highly specialized structure protecting the unique 
      microenvironment of the brain. Endothelial cells, connected by junctional 
      complexes and expressing numerous transporters, constitute the main cell type in 
      the BBB. Other components, including pericytes, basement membrane, astrocytes and 
      perivascular macrophages, join endothelial cells to form the neurovascular unit 
      (NVU) and contribute to the proper function and integrity of the BBB. The role of 
      the BBB in the pathogenesis of diabetic encephalopathy and other diabetes-related 
      complications in the central nervous system is apparent. However, the mechanisms, 
      timing and consequences of BBB injury in diabetes are not well understood. The 
      importance of further studies related to barrier dysfunction in diabetes is 
      dictated by its potential involvement in the cognitive demise associated with DM. 
      This review summarizes the impact of DM on BBB/NVU integrity and function leading 
      to neurological and cognitive complications.
FAU - Bogush, Marina
AU  - Bogush M
AD  - Department of Pathology and Laboratory Medicine, Temple University Lewis Katz 
      School of Medicine, Philadelphia, PA, 19140, USA.
FAU - Heldt, Nathan A
AU  - Heldt NA
AD  - Department of Pathology and Laboratory Medicine, Temple University Lewis Katz 
      School of Medicine, Philadelphia, PA, 19140, USA.
FAU - Persidsky, Yuri
AU  - Persidsky Y
AD  - Department of Pathology and Laboratory Medicine, Temple University Lewis Katz 
      School of Medicine, Philadelphia, PA, 19140, USA. yuri.persidsky@tuhs.temple.edu.
AD  - Center for Substance Abuse Research, Temple University Lewis Katz School of 
      Medicine, Philadelphia, PA, 19140, USA. yuri.persidsky@tuhs.temple.edu.
LA  - eng
GR  - R01 MH106967/MH/NIMH NIH HHS/United States
GR  - AA015913/National Institute on Alcohol Abuse and Alcoholism/
GR  - MH106967/National Institute of Mental Health/
GR  - R01 MH065151/MH/NIMH NIH HHS/United States
GR  - P30 DA013429/DA/NIDA NIH HHS/United States
GR  - U01 AA023552/AA/NIAAA NIH HHS/United States
GR  - R01 DA040619/DA/NIDA NIH HHS/United States
GR  - R37 AA015913/AA/NIAAA NIH HHS/United States
GR  - MH65151/National Institute of Mental Health/
GR  - DA013429/National Institute on Drug Abuse/
GR  - R01 AA015913/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170529
PL  - United States
TA  - J Neuroimmune Pharmacol
JT  - Journal of neuroimmune pharmacology : the official journal of the Society on 
      NeuroImmune Pharmacology
JID - 101256586
SB  - IM
MH  - Blood-Brain Barrier/*pathology
MH  - Brain/*pathology
MH  - Cognition
MH  - Cognition Disorders/etiology/*pathology
MH  - Diabetes Complications/*pathology
MH  - Diabetes Mellitus/*pathology
MH  - Humans
PMC - PMC5693692
MID - NIHMS880364
OTO - NOTNLM
OT  - Blood brain barrier
OT  - Cognitive impairment
OT  - Diabetes
OT  - Endothelial cell
OT  - Neuroinflammation
OT  - Pericyte
EDAT- 2017/05/31 06:00
MHDA- 2018/06/30 06:00
PMCR- 2018/12/01
CRDT- 2017/05/31 06:00
PHST- 2017/02/26 00:00 [received]
PHST- 2017/05/19 00:00 [accepted]
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2018/06/30 06:00 [medline]
PHST- 2017/05/31 06:00 [entrez]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 10.1007/s11481-017-9752-7 [pii]
AID - 10.1007/s11481-017-9752-7 [doi]
PST - ppublish
SO  - J Neuroimmune Pharmacol. 2017 Dec;12(4):593-601. doi: 10.1007/s11481-017-9752-7. 
      Epub 2017 May 29.