PMID- 28557338
OWN - NLM
STAT- MEDLINE
DCOM- 20181107
LR  - 20210109
IS  - 1542-474X (Electronic)
IS  - 1082-720X (Print)
IS  - 1082-720X (Linking)
VI  - 23
IP  - 1
DP  - 2018 Jan
TI  - Coronary sinus lead delay index for optimization of coronary sinus lead 
      placement.
LID - 10.1111/anec.12454 [doi]
LID - e12454
AB  - AIM: Optimization of coronary sinus (CS) lead position to the latest activated 
      left ventricular (LV) area is important to increase cardiac resynchronization 
      therapy (CRT) response. We aimed to detect the relationship between coronary 
      sinus lead delay index (CSDI) and echocardiographic, electrocardiographic 
      response to CRT treatment. METHODS: We prospectively included 137 consecutive 
      patients with heart failure (HF) diagnosis, QRS >/= 120 ms, left bundle branch 
      block (LBBB), New York Heart Association score (NYHA) II-IV, LV ejection fraction 
      (LVEF) <35% and scheduled for CRT (84 male, 53 female; mean age 
      65.1 +/- 10.1 years). Echocardiographic CRT response was defined as >/=15% reduction 
      in LV end-systolic volume (LVESV). CS lead sensing delay was calculated as the 
      time interval from the onset of surface QRS wave to the onset of depolarization 
      wave recorded from the CS lead by using the CS pacing lead as a bipolar 
      electrode. CSDI was calculated by dividing the CS lead sensing delay by the QRS 
      duration. RESULTS: LVESV reduction was associated with baseline QRS width 
      (r = .257, p = .002), QRS narrowing (r = .396, p < .001), CSDI (r = .357, 
      p < .001), and NT-proBNP (r = -0.213, p = .022) in bivariate analysis. In 
      logistic regression analysis, CSDI was found to be only independent parameter for 
      predicting significant LVESV reduction (Beta = 0.318, p < .001). CSDI was also 
      found to be significantly associated with LVEF increase (r = .244, p = .004) and 
      QRS narrowing (r = .178, p = .046). CONCLUSION: CSDI may be used as a marker to 
      predict the favorable response to CRT. It may be useful to integrate CSDI to CRT 
      implantation procedure in order to minimize nonresponders.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Koc, Mevlut
AU  - Koc M
AD  - Department of Cardiology, Adana Health Practices and Research Center, Health 
      Sciences University, Adana, Turkey.
FAU - Kaypakli, Onur
AU  - Kaypakli O
AUID- ORCID: 0000-0002-5065-3283
AD  - Department of Cardiology, Adana Health Practices and Research Center, Health 
      Sciences University, Adana, Turkey.
FAU - Gozubuyuk, Gokhan
AU  - Gozubuyuk G
AD  - Department of Cardiology, Adana Health Practices and Research Center, Health 
      Sciences University, Adana, Turkey.
FAU - Yildiray Sahin, Durmus
AU  - Yildiray Sahin D
AD  - Department of Cardiology, Adana Health Practices and Research Center, Health 
      Sciences University, Adana, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170530
PL  - United States
TA  - Ann Noninvasive Electrocardiol
JT  - Annals of noninvasive electrocardiology : the official journal of the 
      International Society for Holter and Noninvasive Electrocardiology, Inc
JID - 9607443
SB  - IM
MH  - Aged
MH  - Bundle-Branch Block/diagnosis/physiopathology/therapy
MH  - *Cardiac Resynchronization Therapy
MH  - Coronary Sinus/diagnostic imaging/*physiopathology
MH  - *Echocardiography
MH  - *Electrocardiography
MH  - Female
MH  - Heart Diseases/diagnosis/diagnostic imaging/*physiopathology/therapy
MH  - Heart Failure/diagnosis/physiopathology/therapy
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/*diagnosis/physiopathology/therapy
PMC - PMC6931890
OTO - NOTNLM
OT  - CRT response
OT  - QRS width
OT  - coronary sinus lead delay index
EDAT- 2017/05/31 06:00
MHDA- 2018/11/08 06:00
PMCR- 2017/05/30
CRDT- 2017/05/31 06:00
PHST- 2016/11/30 00:00 [received]
PHST- 2017/02/16 00:00 [accepted]
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2018/11/08 06:00 [medline]
PHST- 2017/05/31 06:00 [entrez]
PHST- 2017/05/30 00:00 [pmc-release]
AID - ANEC12454 [pii]
AID - 10.1111/anec.12454 [doi]
PST - ppublish
SO  - Ann Noninvasive Electrocardiol. 2018 Jan;23(1):e12454. doi: 10.1111/anec.12454. 
      Epub 2017 May 30.