PMID- 28557861
OWN - NLM
STAT- MEDLINE
DCOM- 20180518
LR  - 20181202
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 63
IP  - 6
DP  - 2017 Nov/Dec
TI  - HeartMate 3 in Lowest INTERMACS Profile Cohort: The Swiss Experience.
PG  - 752-758
LID - 10.1097/MAT.0000000000000589 [doi]
AB  - New generation devices for long-term mechanical circulatory support are 
      centrifugal pumps having fully magnetically levitated rotors to reduce blood 
      trauma. Recently, the novel HeartMate 3 was cleared for clinical application in 
      Switzerland. In two Swiss University Hospitals part of the "Lausanne-Geneva 
      Transplantation Network," 10 consecutive patients in end-stage heart failure 
      received the HeartMate 3 (Thoratec Corporation, Pleasanton, CA). Device 
      implantation criteria were persistent low output syndrome despite optimal medical 
      treatment. The primary end-point of the study was survival or transplantation to 
      90 days on the device. Five patients (50%) were in Interagency Registry for 
      Mechanically Assisted Circulatory Support (INTERMACS) class 1 and 2 (two were 
      under venoarterial extracorporeal membrane oxygenation [VA-ECMO]), and five were 
      in class 3 and 4. The indication was bridge-to-transplant in seven patients, and 
      destination therapy in three. Two patients (20%) received concomitant aortic 
      valve surgery. Four patients (40%) required temporary right ventricle support 
      (tRVAD) for a mean of 8 +/- 1.5 days. Bleeding requiring surgical revision occurred 
      in five (50%) patients, two during the tRVAD support. At the 90 day end-point, 
      survival was 90%, one (10%) died due to respiratory failure. Three (30%) 
      experienced critical illness polyneuropathy. Two had body temperature over 38.5 degrees C 
      for more than 7 days after implant, without infections. Two (20%) had late 
      driveline infection. The pump allowed rapid improvement of patients' clinical 
      conditions even in severely compromised patients. Postoperative bleeding occurred 
      in the setting of anticoagulation. No hemolysis or pump thrombosis occurred. 
      Fever occurred frequently but was not associated with mortality. Hemodynamic 
      support was consistent over time without significant adverse events.
FAU - Tozzi, Piergiorgio
AU  - Tozzi P
AD  - From the *Department of Cardiac Surgery, Centre Hospitalier Universitaire Vaudois 
      (CHUV), Lausanne, Switzerland; daggerDepartment of Cardiovascular Surgery, Hopitaux 
      Universitaires de Geneve (HUG), Geneva, Switzerland; double daggerDepartment of Cardiology, 
      Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; 
       section signDepartment of Cardiology, Hopitaux Universitaires de Geneve (HUG), Geneve, 
      Switzerland;  paragraph signDepartment of Intensive Care Unit, Hopitaux Universitaires de 
      Geneve (HUG), Geneva, Switzerland;  ||Department of Intensive Care Unit, Centre 
      Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; and #Department 
      of Anesthesiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, 
      Switzerland.
FAU - Banfi, Carlo
AU  - Banfi C
FAU - Ahmadov, Kameran
AU  - Ahmadov K
FAU - Hullin, Roger
AU  - Hullin R
FAU - Meyer, Philippe
AU  - Meyer P
FAU - Giraud, Raphael
AU  - Giraud R
FAU - Liaudet, Lucas
AU  - Liaudet L
FAU - Gronchi, Fabrizio
AU  - Gronchi F
FAU - Huber, Christophe
AU  - Huber C
FAU - Kirsch, Matthias
AU  - Kirsch M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Heart Failure/mortality/therapy
MH  - Heart Transplantation
MH  - Heart-Assist Devices/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Registries
EDAT- 2017/05/31 06:00
MHDA- 2018/05/19 06:00
CRDT- 2017/05/31 06:00
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2018/05/19 06:00 [medline]
PHST- 2017/05/31 06:00 [entrez]
AID - 10.1097/MAT.0000000000000589 [doi]
PST - ppublish
SO  - ASAIO J. 2017 Nov/Dec;63(6):752-758. doi: 10.1097/MAT.0000000000000589.