PMID- 28558042
OWN - NLM
STAT- MEDLINE
DCOM- 20170921
LR  - 20190208
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 5
DP  - 2017
TI  - Relationships of growth factors, proinflammatory cytokines, and anti-inflammatory 
      cytokines with long-term clinical results of autologous bone marrow mononuclear 
      cell transplantation in STEMI.
PG  - e0176900
LID - 10.1371/journal.pone.0176900 [doi]
LID - e0176900
AB  - AIM: The aim of the study was to test the hypothesis suggesting that the 
      pre-intervention levels of proinflammatory cytokines, anti-inflammatory 
      cytokines, and angiogenic growth factors predict the long-term clinical results 
      of autologous bone marrow-derived mononuclear cell (ABMMC) transplantation in 
      patients with primary ST elevation myocardial infarction (STEMI). METHODS AND 
      RESULTS: From 2003 to 2006, a total of 62 patients with primary STEMI were 
      enrolled in an open randomized study registered under the title ESTABOMA. 
      Patients were randomized into two groups: group 1 included patients treated with 
      percutaneous coronary intervention (PCI) and ABMMC transplantation (n = 28); 
      group 2 comprised patients treated only with PCI (n = 34). Follow-up study was 
      performed 7.96 +/- 0.96 years after STEMI and involved physical examination, 
      six-minute walk test, echocardiography, and determination of brain natriuretic 
      peptide (BNP) levels. The total and cardiovascular mortality rates were higher in 
      group 1 compared with group 2: 36% (n = 10) vs. 12% (n = 4) (p = 0.02) and 29% (n 
      = 8) vs. 6% (n = 2) (p = 0.03), respectively. Lower levels of proinflammatory 
      cytokines were observed in group 1 after PCI and ABMMC transplantation. Serum 
      levels of FGF, VEGF, and IL-10, determined before PCI and ABMMC transplantation 
      were prognostically significant long-term indicators of unfavorable course of CAD 
      after STEMI.
FAU - Ryabov, Vyacheslav V
AU  - Ryabov VV
AUID- ORCID: 0000-0002-4358-7329
AD  - Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, 
      Russian Federation.
AD  - Siberian State Medical University, Department of Cardiology at the Faculty of 
      Continuous Medical Education, Tomsk, Russian Federation.
AD  - National Research Tomsk State University, Laboratory of Translational Cellular 
      and Molecular Biomedicine, Tomsk, Russian Federation.
FAU - Kirgizova, Marina A
AU  - Kirgizova MA
AD  - Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, 
      Russian Federation.
FAU - Suslova, Tatiana E
AU  - Suslova TE
AD  - Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, 
      Russian Federation.
AD  - National Research Tomsk State University, Laboratory of Translational Cellular 
      and Molecular Biomedicine, Tomsk, Russian Federation.
FAU - Karas, Sergei I
AU  - Karas SI
AD  - Siberian State Medical University, Department of Cardiology at the Faculty of 
      Continuous Medical Education, Tomsk, Russian Federation.
FAU - Markov, Valentin A
AU  - Markov VA
AD  - Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, 
      Russian Federation.
AD  - Siberian State Medical University, Department of Cardiology at the Faculty of 
      Continuous Medical Education, Tomsk, Russian Federation.
FAU - Karpov, Rostislav S
AU  - Karpov RS
AD  - Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, 
      Russian Federation.
AD  - Siberian State Medical University, Department of Cardiology at the Faculty of 
      Continuous Medical Education, Tomsk, Russian Federation.
LA  - eng
PT  - Journal Article
DEP - 20170530
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Bone Marrow Transplantation/*methods
MH  - Cytokines/*physiology
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*physiology
MH  - Intercellular Signaling Peptides and Proteins/*physiology
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/physiopathology/*surgery
MH  - Transplantation, Autologous
PMC - PMC5448725
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/05/31 06:00
MHDA- 2017/09/22 06:00
PMCR- 2017/05/30
CRDT- 2017/05/31 06:00
PHST- 2016/07/26 00:00 [received]
PHST- 2017/04/19 00:00 [accepted]
PHST- 2017/05/31 06:00 [entrez]
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2017/09/22 06:00 [medline]
PHST- 2017/05/30 00:00 [pmc-release]
AID - PONE-D-16-26997 [pii]
AID - 10.1371/journal.pone.0176900 [doi]
PST - epublish
SO  - PLoS One. 2017 May 30;12(5):e0176900. doi: 10.1371/journal.pone.0176900. 
      eCollection 2017.