PMID- 28558148
OWN - NLM
STAT- MEDLINE
DCOM- 20180426
LR  - 20180507
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 7
IP  - 8
DP  - 2017 Aug
TI  - Glucosamine has an antiallergic effect in mice with allergic asthma and rhinitis.
PG  - 763-769
LID - 10.1002/alr.21967 [doi]
AB  - BACKGROUND: Glucosamine (GlcN) is generally used as a dietary supplement because 
      of its antiinflammatory effects. We evaluated the antiallergic effect of GlcN in 
      mice with allergic asthma and rhinitis. METHODS: Thirty-two mice were allocated 
      equally into 4 groups (n = 8). In group A (control), we performed 
      intraperitoneal/intranasal challenge using sterile saline. In group B 
      (asthma/rhinitis), we used ovalbumin for intraperitoneal/intranasal challenge to 
      induce allergic asthma and rhinitis. In groups C and D (GlcN treatment), mice 
      were given 1% and 5% GlcN throughout the period of ovalbumin challenge, 
      respectively. We measured serum total and ovalbumin-specific immunoglobulin E 
      (IgE), cytokine titers (interleukin-1, -4, -5, -6, -10, and -17; tumor necrosis 
      factor-alpha; and interferon-gamma), and the number of inflammatory cells (eosinophils, 
      neutrophils, lymphocytes) in bronchoalveolar lavage (BAL) fluid. We also 
      performed histopathologic examination of the lung and nasal cavity. Finally, we 
      performed real-time polymerase chain reaction for the genes Bcl-2, EC-SOD, VEGF, 
      caspase-3, Bax, COX-2, Hif-1alpha, and heme oxygenase-1. RESULTS: Compared with group 
      B, group D had significant serum total and ovalbumin-specific IgE decreases after 
      GlcN treatment (p < 0.05). Titers for IL-4, IL-5, IL-6, and IL-17 in BAL fluid 
      were significantly decreased in group D (p < 0.05). Eosinophils in BAL fluid were 
      significantly decreased in group D compared with group B (p < 0.05). Groups C and 
      D showed significant improvement of inflammation compared with group B. Group D 
      had significant downregulation of EC-SOD, Bax, Hif-1alpha, and heme oxygenase-1 
      compared with group B. CONCLUSION: GlcN had a significant antiallergic effect in 
      mice with allergic asthma and rhinitis.
CI  - (c) 2017 ARS-AAOA, LLC.
FAU - Jung, Ah-Yeoun
AU  - Jung AY
AD  - WCSL of INtegrated Human Airway-on-a-chip, Department of Otorhinolaryngology, 
      Inha University, Incheon, Korea.
FAU - Heo, Min-Jeong
AU  - Heo MJ
AD  - WCSL of INtegrated Human Airway-on-a-chip, Department of Otorhinolaryngology, 
      Inha University, Incheon, Korea.
FAU - Kim, Young Hyo
AU  - Kim YH
AD  - WCSL of INtegrated Human Airway-on-a-chip, Department of Otorhinolaryngology, 
      Inha University, Incheon, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170530
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Allergens)
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Bax protein, mouse)
RN  - 0 (Cytokines)
RN  - 0 (Hif1a protein, mouse)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (bcl-2-Associated X Protein)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - N08U5BOQ1K (Glucosamine)
SB  - IM
MH  - Allergens
MH  - Animals
MH  - Anti-Allergic Agents/pharmacology/*therapeutic use
MH  - Asthma/blood/*drug therapy/genetics/immunology
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - Cytokines/immunology
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Glucosamine/pharmacology/*therapeutic use
MH  - Heme Oxygenase-1/genetics
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics
MH  - Immunoglobulin E/blood
MH  - Leukocyte Count
MH  - Lung/pathology
MH  - Mice, Inbred BALB C
MH  - Nasal Mucosa/pathology
MH  - Ovalbumin
MH  - Rhinitis, Allergic/blood/*drug therapy/genetics/immunology
MH  - Superoxide Dismutase/genetics
MH  - bcl-2-Associated X Protein/genetics
OTO - NOTNLM
OT  - allergic rhinitis
OT  - asthma
OT  - glucosamine
OT  - heme oxygenase-1
OT  - hypoxia-inducible factor-1
OT  - superoxide dismutase
EDAT- 2017/05/31 06:00
MHDA- 2018/04/27 06:00
CRDT- 2017/05/31 06:00
PHST- 2017/02/16 00:00 [received]
PHST- 2017/04/18 00:00 [revised]
PHST- 2017/05/02 00:00 [accepted]
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2018/04/27 06:00 [medline]
PHST- 2017/05/31 06:00 [entrez]
AID - 10.1002/alr.21967 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2017 Aug;7(8):763-769. doi: 10.1002/alr.21967. Epub 
      2017 May 30.