PMID- 28558302
OWN - NLM
STAT- MEDLINE
DCOM- 20180501
LR  - 20180501
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 49
DP  - 2017 Aug
TI  - Anti-inflammatory effect of epigallocatechin gallate in a mouse model of 
      ovalbumin-induced allergic rhinitis.
PG  - 102-108
LID - S1567-5769(17)30203-5 [pii]
LID - 10.1016/j.intimp.2017.05.030 [doi]
AB  - Currently, a variety of studies have demonstrated that green tea has 
      anti-allergic properties, and the major polyphenolic compound, epigallocatechin 
      gallate (EGCG), plays a significant role. Some research indicates that EGCG 
      reduces the production and expression of allergy-related substances. Therefore, 
      EGCG has a potential effect of reducing allergic rhinitis (AR). In this study, 
      the effect of EGCG on allergic rhinitis in an ovalbumin (OVA)-induced mouse model 
      was investigated. After administration of EGCG, the number of sneezes and the 
      occurrence of nasal rubbing were significantly decreased, the concentrations of 
      immunoglobulin E (IgE) and histamine were suppressed in AR mouse serum, the 
      levels of interleukin (IL)-1beta, IL-4, and IL-6 were reduced in AR mice nasal 
      lavage fluid (NLF), and the nasal mucosa mRNA and protein expression of 
      cyclooxygenase 2 (COX-2), IL-1beta, IL-4, and IL-6 were inhibited. The data indicate 
      that EGCG has a beneficial effect of reducing allergic rhinitis.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Fu, Meng
AU  - Fu M
AD  - Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 
      130021, China.
FAU - Fu, Shulian
AU  - Fu S
AD  - Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 
      130021, China.
FAU - Ni, Saihong
AU  - Ni S
AD  - Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 
      130021, China.
FAU - Zou, Liyuan
AU  - Zou L
AD  - China-Japan Union Hospital of Jilin University, Changchun 130021, China.
FAU - Liu, Yumei
AU  - Liu Y
AD  - China-Japan Union Hospital of Jilin University, Changchun 130021, China.
FAU - Hong, Tie
AU  - Hong T
AD  - Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 
      130021, China. Electronic address: hongtie@jlu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170527
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Allergens)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Tea)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
RN  - 8R1V1STN48 (Catechin)
RN  - 9006-59-1 (Ovalbumin)
RN  - BQM438CTEL (epigallocatechin gallate)
RN  - EC 1.14.99.- (Ptgs2 protein, mouse)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Catechin/*analogs & derivatives/therapeutic use
MH  - Cyclooxygenase 2/genetics/metabolism
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Histamine/blood
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Inflammation Mediators/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - Rhinitis, Allergic/*drug therapy
MH  - Sneezing
MH  - Tea/immunology
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - COX-2
OT  - EGCG
OT  - Histamine
OT  - Immunoglobulin E
OT  - Interleukin
EDAT- 2017/05/31 06:00
MHDA- 2018/05/02 06:00
CRDT- 2017/05/31 06:00
PHST- 2017/03/10 00:00 [received]
PHST- 2017/05/09 00:00 [revised]
PHST- 2017/05/23 00:00 [accepted]
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2018/05/02 06:00 [medline]
PHST- 2017/05/31 06:00 [entrez]
AID - S1567-5769(17)30203-5 [pii]
AID - 10.1016/j.intimp.2017.05.030 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2017 Aug;49:102-108. doi: 10.1016/j.intimp.2017.05.030. Epub 
      2017 May 27.