PMID- 28558702
OWN - NLM
STAT- MEDLINE
DCOM- 20171107
LR  - 20181202
IS  - 1471-2253 (Electronic)
IS  - 1471-2253 (Linking)
VI  - 17
IP  - 1
DP  - 2017 May 30
TI  - Background anaesthetic agents do not influence the impact of arginine vasopressin 
      on haemodynamic states and cerebral oxygenation during shoulder surgery in the 
      beach chair position: a prospective, single-blind study.
PG  - 73
LID - 10.1186/s12871-017-0364-9 [doi]
LID - 73
AB  - BACKGROUND: Administration of arginine vasopressin (AVP) is associated with 
      reducing jugular venous (SjvO(2)) and regional cerebral (rScO(2)) oxygen 
      saturation under propofol-remifentanil (P/R) anaesthesia. We determined whether 
      background anaesthetics modulate the effect of AVP on cerebral oxygenation and 
      haemodynamics. METHODS: We randomly allocated 60 adult patients scheduled for 
      shoulder surgery in the beach chair position (BCP) into 4 groups, to receive 
      either an intravenous bolus of saline (groups PR-S and SN-S) or 0.05 U/kg AVP 
      (groups PR-AVP and SN-AVP) under P/R or sevoflurane-nitrous oxide (S/N) 
      anaesthesia (n = 15 each). Haemodynamic variables, SjvO(2) and rScO(2) were 
      measured. RESULTS: AVP significantly increased mean arterial blood pressure (MAP) 
      and decreased rScO(2) in either anaesthetic group. AVP also decreased SjvO(2) in 
      the P/R groups but not in the S/N groups. The AVP-treated groups showed higher 
      MAP and cerebral desaturation (>20% rScO(2) decrease from baseline), along with 
      lower HR and rScO(2) in the BCP than those in the saline-treated groups. In 
      contrast, AVP did not affect SjvO(2) values or the incidence of SjvO (2)  < 50%. 
      Baseline SjvO(2) was lower and the magnitude of its reduction in the BCP was 
      greater in the PR-AVP group than in the SN-AVP group, and the lowest SjvO(2) 
      values were 37 +/- 6 and 57 +/- 8%, respectively (P < 0.001). CONCLUSIONS: The choice 
      of anaesthetic regimen did not affect cerebral oxygenation or haemodynamics of 
      AVP in the BCP. However, the negative effect of AVP on cerebral oxygenation 
      should be considered, especially under P/R anaesthesia. TRIAL REGISTRATION: 
      ClinicalTrials.gov identifier: NCT01687894 , registered on September 18, 2012.
FAU - Jang, Eun-A
AU  - Jang EA
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, South Korea.
FAU - Song, Ji-A
AU  - Song JA
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, South Korea.
FAU - Shin, Ji Youn
AU  - Shin JY
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, South Korea.
FAU - Yoon, Jae Joon
AU  - Yoon JJ
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, South Korea.
FAU - Yoo, Kyung Yeon
AU  - Yoo KY
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, South Korea.
FAU - Jeong, Seongtae
AU  - Jeong S
AUID- ORCID: 0000-0002-6245-9779
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, South Korea. 
      anesjst@jnu.ac.kr.
LA  - eng
SI  - ClinicalTrials.gov/NCT01687894
SI  - ClinicalTrials.gov/NCT01687894
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170530
PL  - England
TA  - BMC Anesthesiol
JT  - BMC anesthesiology
JID - 100968535
RN  - 0 (Anesthetics)
RN  - 0 (Methyl Ethers)
RN  - 0 (Piperidines)
RN  - 0 (Vasoconstrictor Agents)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 38LVP0K73A (Sevoflurane)
RN  - K50XQU1029 (Nitrous Oxide)
RN  - P10582JYYK (Remifentanil)
RN  - S88TT14065 (Oxygen)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Aged
MH  - Anesthetics/administration & dosage
MH  - Arginine Vasopressin/*administration & dosage
MH  - Blood Pressure/drug effects
MH  - Brain/*metabolism
MH  - Cerebrovascular Circulation
MH  - Female
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Male
MH  - Methyl Ethers/administration & dosage
MH  - Middle Aged
MH  - Nitrous Oxide/administration & dosage
MH  - Oximetry
MH  - Oxygen/*metabolism
MH  - *Patient Positioning
MH  - Piperidines/administration & dosage
MH  - Propofol/administration & dosage
MH  - Prospective Studies
MH  - Remifentanil
MH  - Sevoflurane
MH  - Shoulder Joint/surgery
MH  - Single-Blind Method
MH  - Spectroscopy, Near-Infrared
MH  - Vasoconstrictor Agents/*administration & dosage
PMC - PMC5450390
OTO - NOTNLM
OT  - Anaesthetic
OT  - Arginine vasopressin
OT  - Beach chair position
OT  - Cerebral oxygenation
OT  - Haemodynamics
EDAT- 2017/06/01 06:00
MHDA- 2017/11/08 06:00
PMCR- 2017/05/30
CRDT- 2017/06/01 06:00
PHST- 2017/01/12 00:00 [received]
PHST- 2017/05/22 00:00 [accepted]
PHST- 2017/06/01 06:00 [entrez]
PHST- 2017/06/01 06:00 [pubmed]
PHST- 2017/11/08 06:00 [medline]
PHST- 2017/05/30 00:00 [pmc-release]
AID - 10.1186/s12871-017-0364-9 [pii]
AID - 364 [pii]
AID - 10.1186/s12871-017-0364-9 [doi]
PST - epublish
SO  - BMC Anesthesiol. 2017 May 30;17(1):73. doi: 10.1186/s12871-017-0364-9.