PMID- 28559189
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20190107
IS  - 0005-2736 (Print)
IS  - 1878-2434 (Electronic)
IS  - 0005-2736 (Linking)
VI  - 1860
IP  - 1
DP  - 2018 Jan
TI  - The role of connexin and pannexin containing channels in the innate and acquired 
      immune response.
PG  - 154-165
LID - S0005-2736(17)30176-1 [pii]
LID - 10.1016/j.bbamem.2017.05.015 [doi]
AB  - Connexin (Cx) and pannexin (Panx) containing channels - gap junctions (GJs) and 
      hemichannels (HCs) - are present in virtually all cells and tissues. Currently, 
      the role of these channels under physiological conditions is well defined. 
      However, their role in the immune response and pathological conditions has only 
      recently been explored. Data from several laboratories demonstrates that 
      infectious agents, including HIV, have evolved to take advantage of GJs and HCs 
      to improve viral/bacterial replication, enhance inflammation, and help spread 
      toxicity into neighboring areas. In the current review, we discuss the role of Cx 
      and Panx containing channels in immune activation and the pathogenesis of several 
      infectious diseases. This article is part of a Special Issue entitled: Gap 
      Junction Proteins edited by Jean Claude Herve.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Valdebenito, Silvana
AU  - Valdebenito S
AD  - Public Health Research Institute (PHRI), Newark, NJ, USA; Department of 
      Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical 
      School, Rutgers the State University of New Jersey, Newark, NJ, USA.
FAU - Barreto, Andrea
AU  - Barreto A
AD  - Public Health Research Institute (PHRI), Newark, NJ, USA; Department of 
      Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical 
      School, Rutgers the State University of New Jersey, Newark, NJ, USA.
FAU - Eugenin, Eliseo A
AU  - Eugenin EA
AD  - Public Health Research Institute (PHRI), Newark, NJ, USA; Department of 
      Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical 
      School, Rutgers the State University of New Jersey, Newark, NJ, USA. Electronic 
      address: eliseo.eugenin@rutgers.edu.
LA  - eng
GR  - R01 MH096625/MH/NIMH NIH HHS/United States
GR  - R01 NS105584/NS/NINDS NIH HHS/United States
GR  - MH096625/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170527
PL  - Netherlands
TA  - Biochim Biophys Acta Biomembr
JT  - Biochimica et biophysica acta. Biomembranes
JID - 101731713
RN  - 0 (Connexins)
SB  - IM
MH  - *Adaptive Immunity
MH  - Animals
MH  - Bacteria/*immunology
MH  - Bacterial Infections/*immunology
MH  - Connexins/*immunology
MH  - Gap Junctions/*immunology
MH  - HIV Infections/*immunology
MH  - HIV-1/*immunology
MH  - Humans
MH  - *Immunity, Innate
PMC - PMC6065251
MID - NIHMS982691
OTO - NOTNLM
OT  - Anti-retroviral
OT  - Apoptosis
OT  - Cure
OT  - NeuroAIDS
OT  - Reservoirs
COIS- Conflict of interest None.
EDAT- 2017/06/01 06:00
MHDA- 2018/03/10 06:00
PMCR- 2019/01/01
CRDT- 2017/06/01 06:00
PHST- 2017/01/19 00:00 [received]
PHST- 2017/05/17 00:00 [revised]
PHST- 2017/05/25 00:00 [accepted]
PHST- 2017/06/01 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2017/06/01 06:00 [entrez]
PHST- 2019/01/01 00:00 [pmc-release]
AID - S0005-2736(17)30176-1 [pii]
AID - 10.1016/j.bbamem.2017.05.015 [doi]
PST - ppublish
SO  - Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):154-165. doi: 
      10.1016/j.bbamem.2017.05.015. Epub 2017 May 27.