PMID- 28559533
OWN - NLM
STAT- MEDLINE
DCOM- 20190424
LR  - 20190424
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 18
IP  - 1
DP  - 2017 Jul
TI  - Assessment of the association between the presence of fragmented QRS and the 
      predicted risk score of sudden cardiac death at 5 years in patients with 
      hypertrophic cardiomyopathy.
PG  - 54-61
LID - 10.14744/AnatolJCardiol.2017.7593 [doi]
AB  - OBJECTIVE: It has been shown that the presence of fragmented QRS (fQRS) is 
      associated with poor prognosis in many cardiovascular diseases and in patients 
      with hypertrophic cardiomyopathy (HCM). However, no study has shown an 
      association with the absolute risk score of sudden cardiac death. The aim of this 
      study was to determine the relationship between QRS and the predicted risk score 
      of sudden cardiac death at 5 years (HCM Risk-SCD) in HCM patients. METHODS: In 
      total, 115 consecutive HCM patients were included in this prospective 
      observational study. The patients were divided into two groups according to the 
      presence [fQRS(+) group (n=65)] or absence [fQRS(-) group (n=50)] of fQRS on a 
      12-lead electrocardiogram (ECG). RESULTS: The HCM Risk-SCD (%) HCM Risk-SCD (>6%) 
      values and some echocardiographic parameters, including ventricular extrasystole, 
      ventricular tachycardia, cardiopulmonary resuscitation, implantable cardioverter 
      defibrillator implantation, appropriate shock, and heart failure at the time of 
      admission, were significantly higher in the fQRS(+) group than in the fQRS(-) 
      group (all p<0.05). Both univariate and multivariate analyses revealed fQRS and 
      New York Heart Association (NYHA) class as independent predictors of HCM 
      Risk-SCD. In a receiver operating characteristic (ROC) curve analysis, an HCM 
      Risk-SCD value of >4 was identified as an effective cut-off point in fQRS for 
      HCM. An HCM Risk-SCD value of >4 yielded a sensitivity of 77% and a specificity 
      of 76%. CONCLUSION: fQRS is determined to be an independent high-risk indicator 
      of HCM Risk-SCD. It seems to be associated with increased ventricular arrhythmias 
      and some echocardiographic parameters.
FAU - Ozyilmaz, Sinem
AU  - Ozyilmaz S
AD  - Department of Cardiology, Faculty of Medicine, Biruni University; 
      Istanbul-Turkey. drsinemozbey@gmail.com.
FAU - Akgul, Ozgur
AU  - Akgul O
FAU - Uyarel, Huseyin
AU  - Uyarel H
FAU - Pusuroglu, Hamdi
AU  - Pusuroglu H
FAU - Karayakali, Muammer
AU  - Karayakali M
FAU - Gul, Mehmet
AU  - Gul M
FAU - Cetin, Mustafa
AU  - Cetin M
FAU - Satilmisoglu, Hulusi
AU  - Satilmisoglu H
FAU - Yildirim, Aydin
AU  - Yildirim A
FAU - Bakir, Ihsan
AU  - Bakir I
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170530
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
SB  - IM
MH  - Cardiomyopathy, Hypertrophic/*mortality
MH  - Death, Sudden, Cardiac/*etiology
MH  - *Electrocardiography
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Heart Conduction System/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Survival Analysis
MH  - Turkey
PMC - PMC5512199
COIS- Conflict of interest: None declared.
EDAT- 2017/06/01 06:00
MHDA- 2019/04/25 06:00
PMCR- 2017/07/01
CRDT- 2017/06/01 06:00
PHST- 2017/06/01 06:00 [pubmed]
PHST- 2019/04/25 06:00 [medline]
PHST- 2017/06/01 06:00 [entrez]
PHST- 2017/07/01 00:00 [pmc-release]
AID - AJC-18-54 [pii]
AID - 10.14744/AnatolJCardiol.2017.7593 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2017 Jul;18(1):54-61. doi: 10.14744/AnatolJCardiol.2017.7593. 
      Epub 2017 May 30.