PMID- 28560422
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20181113
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 16
IP  - 1
DP  - 2017 Jul
TI  - Effects of maternal acrolein exposure during pregnancy on testicular testosterone 
      production in fetal rats.
PG  - 491-498
LID - 10.3892/mmr.2017.6624 [doi]
AB  - Acrolein has been reported to have diverse toxic effects on various organs, 
      including the reproductive system. However, little is known regarding the effects 
      of maternal acrolein exposure on testicular steroidogenesis in male offspring. 
      The present study investigated the effects of acrolein on fetal testosterone 
      production and associated genes. Pregnant Sprague‑Dawley rats were 
      intraperitoneally injected with vehicle (normal saline) or 1, 2 or 5 mg/kg 
      acrolein from gestational day (GD) 14‑20, and fetal testes were examined on GD 
      21. Fetal body and testicular weights were markedly reduced in pups following 
      exposure to high doses of acrolein (5 mg/kg) in late pregnancy. Notably, in utero 
      exposure of 5 mg/kg acrolein significantly decreased the testicular testosterone 
      level and downregulated the expression levels of steroidogenic acute regulatory 
      protein (StAR) and 3beta‑hydroxysteroid dehydrogenase (3beta‑HSD), whereas the levels 
      of other steroidogenic enzymes, including scavenger receptor class B, cholesterol 
      side‑chain cleavage enzyme and steroid 17 alpha‑hydroxylase/17,20 lyase, were 
      unaffected. Furthermore, the 3beta‑HSD immunoreactive area in the interstitial 
      region of the fetal testes was reduced at a 5 mg/kg dose, whereas the protein 
      expression levels of 4‑hydroxynonenalwere dose‑dependently increased following 
      maternal exposure to acrolein. mRNA expression levels of insulin‑like factor 3, a 
      critical gene involved in testicular descent, were unaltered following maternal 
      acrolein exposure. Taken together, the results of the present study suggested 
      that maternal exposure to high doses of acrolein inhibited fetal testosterone 
      synthesis, and abnormal expression of StAR and 3beta‑HSD may be associated with 
      impairment of the steroidogenic capacity.
FAU - Yang, Yuzhuo
AU  - Yang Y
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, P.R. 
      China.
FAU - Zhang, Zhe
AU  - Zhang Z
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, P.R. 
      China.
FAU - Zhang, Hongliang
AU  - Zhang H
AD  - Reproductive Medicine Center, Peking University Third Hospital, Beijing 100191, 
      P.R. China.
FAU - Hong, Kai
AU  - Hong K
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, P.R. 
      China.
FAU - Tang, Wenhao
AU  - Tang W
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, P.R. 
      China.
FAU - Zhao, Lianming
AU  - Zhao L
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, P.R. 
      China.
FAU - Lin, Haocheng
AU  - Lin H
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, P.R. 
      China.
FAU - Liu, Defeng
AU  - Liu D
AD  - Reproductive Medicine Center, Peking University Third Hospital, Beijing 100191, 
      P.R. China.
FAU - Mao, Jiaming
AU  - Mao J
AD  - Reproductive Medicine Center, Peking University Third Hospital, Beijing 100191, 
      P.R. China.
FAU - Wu, Han
AU  - Wu H
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, P.R. 
      China.
FAU - Jiang, Hui
AU  - Jiang H
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, P.R. 
      China.
LA  - eng
PT  - Journal Article
DEP - 20170525
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Insulin)
RN  - 0 (Leydig insulin-like protein)
RN  - 0 (Proteins)
RN  - 3XMK78S47O (Testosterone)
RN  - 7864XYD3JJ (Acrolein)
SB  - IM
MH  - *Acrolein/adverse effects
MH  - Animals
MH  - Female
MH  - *Fetus
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Insulin/genetics/metabolism
MH  - Male
MH  - *Maternal Exposure
MH  - Pregnancy
MH  - Proteins/genetics/metabolism
MH  - Rats
MH  - Testis/*drug effects/*metabolism
MH  - Testosterone/*biosynthesis
PMC - PMC5482093
EDAT- 2017/06/01 06:00
MHDA- 2018/03/27 06:00
PMCR- 2017/05/25
CRDT- 2017/06/01 06:00
PHST- 2015/11/24 00:00 [received]
PHST- 2016/11/29 00:00 [accepted]
PHST- 2017/06/01 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/06/01 06:00 [entrez]
PHST- 2017/05/25 00:00 [pmc-release]
AID - mmr-16-01-0491 [pii]
AID - 10.3892/mmr.2017.6624 [doi]
PST - ppublish
SO  - Mol Med Rep. 2017 Jul;16(1):491-498. doi: 10.3892/mmr.2017.6624. Epub 2017 May 
      25.