PMID- 28562580
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 22
DP  - 2017 Jun
TI  - Increased serum brain-derived neurotrophic factor in male schizophrenic patients 
      with metabolic syndrome.
PG  - e7089
LID - 10.1097/MD.0000000000007089 [doi]
LID - e7089
AB  - Increased prevalence of metabolic syndrome was found in patients with 
      schizophrenia. Brain-derived neurotrophic factor (BDNF) was involved in energy 
      metabolism and the pathophysiology of schizophrenia, but differently in males and 
      females. We aimed to investigate the serum BDNF levels in patients with 
      schizophrenia with and without metabolic syndrome.Patients with schizophrenia 
      were recruited. Their demographic data were collected. Metabolic profiles and 
      serum BDNF levels were measured. Clinical symptoms were evaluated with Positive 
      and Negative Syndrome Scale. Metabolic syndrome was determined with the criteria 
      provided by Ministry of Health and Welfare of Taiwan. Framingham Risk Score (FRS) 
      for estimate of 10-year risk for coronary heart disease was provided by National 
      Institutes of Health.Of the 81 participants, 40.7% had metabolic syndrome. Those 
      with metabolic syndrome had higher FRS. Using analysis of covariance adjusted for 
      age and body mass index, male patients with schizophrenia with metabolic syndrome 
      had higher serum BDNF levels than those without (4.6 +/- 4.7 vs 3.3 +/- 3.8 ng/mL, 
      P = .022). No statistical difference was found between female patients with and 
      without metabolic syndrome.Significant differences of serum BDNF levels were 
      found between male patients with schizophrenia with and without metabolic 
      syndrome, but not in females. This finding suggested the gender difference behind 
      the mechanism of BDNF in metabolic syndrome in schizophrenia.
FAU - Lin, Chin-Chuen
AU  - Lin CC
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Hung, Yi-Yung
AU  - Hung YY
FAU - Tsai, Meng-Chang
AU  - Tsai MC
FAU - Huang, Tiao-Lai
AU  - Huang TL
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Blood Chemical Analysis
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*blood/*complications
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*blood/*complications
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Young Adult
PMC - PMC5459745
COIS- The authors report no conflicts of interest.
EDAT- 2017/06/01 06:00
MHDA- 2017/07/01 06:00
PMCR- 2017/06/02
CRDT- 2017/06/01 06:00
PHST- 2017/06/01 06:00 [entrez]
PHST- 2017/06/01 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2017/06/02 00:00 [pmc-release]
AID - 00005792-201706020-00056 [pii]
AID - MD-D-16-07748 [pii]
AID - 10.1097/MD.0000000000007089 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jun;96(22):e7089. doi: 10.1097/MD.0000000000007089.