PMID- 28564523
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20181202
IS  - 0890-9016 (Print)
IS  - 0890-9016 (Linking)
VI  - 32
DP  - 2016
TI  - HLA Epitopes - Are We Ready for Clinical Prime Time? Historic Perspective and 
      Future Needs.
PG  - 63-71
AB  - A significant barrier to long-term transplant success is the development of de 
      novo donor-specific human leukocyte antigen (HLA) antibodies. The best approach 
      to minimize the risk of developing such antibodies is an HLA identical 
      transplant, but the likelihood of finding such an organ is very low. The 
      alternative is to identify "permissible mismatches" - HLA antigen mismatches that 
      are less likely to induce an immune response. In the past few years, it has 
      become clear that matching at the "epitope level" is the likely solution; 
      however, we are still struggling with how to define HLA epitopes. Herein, we 
      provide a short review of the development of the epitope concept within the HLA 
      field, with the hope that it sheds light on present knowledge. We follow with our 
      personal opinion on where the future is leading us.
CI  - Copyright(c) 2017 by the Terasaki Research Institute.
FAU - Dvorai, Reut H
AU  - Dvorai RH
AD  - Transplant Immunology Laboratory, Comprehensive Transplant Center, Chicago, IL.
FAU - Pinelli, David F
AU  - Pinelli DF
AD  - Transplant Immunology Laboratory, Comprehensive Transplant Center, Chicago, IL.
FAU - Tambur, Anat R
AU  - Tambur AR
AD  - Transplant Immunology Laboratory, Comprehensive Transplant Center, Chicago, IL.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Transpl
JT  - Clinical transplants
JID - 8812419
RN  - 0 (Antibodies)
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibodies
MH  - *Epitopes
MH  - HLA Antigens
MH  - *Histocompatibility Testing
MH  - Humans
MH  - *Tissue Donors
OTO - NOTNLM
OT  - donor-specific antibodies
OT  - epitope
OT  - transplantation
EDAT- 2016/01/01 00:00
MHDA- 2018/07/24 06:00
CRDT- 2017/06/01 06:00
PHST- 2017/06/01 06:00 [entrez]
PHST- 2016/01/01 00:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PST - ppublish
SO  - Clin Transpl. 2016;32:63-71.