PMID- 28564525
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20181202
IS  - 0890-9016 (Print)
IS  - 0890-9016 (Linking)
VI  - 32
DP  - 2016
TI  - Acute Rejection, Kidney Allograft Function, and Graft Survival in Patients with 
      Circulating Pre-Transplant IgG Antibodies Directed Against Donor HLA-A, -B, or -C 
      Locus Determined Antigens.
PG  - 83-91
AB  - The relationship between circulating pre-transplant immunoglobulin G (IgG) 
      antibodies to donor human leukocyte antigen (HLA) -C locus determined antigens 
      alone and acute rejection, kidney allograft function, and graft survival is not 
      fully defined. Also, the impact of circulating pre-transplant IgG antibodies to 
      donor HLA-C locus antigens alone on these outcomes has not been compared with the 
      impact of circulating pre-transplant IgG antibodies to donor HLA-A or -B locus 
      antigens. We conducted a retrospective review of records of 1252 kidney allograft 
      recipients transplanted at our center between January 2010 and January 2016 to 
      identify patients with circulating pre-transplant IgG antibodies directed at 
      kidney donor HLA-A, -B, or -C locus determined antigens. Antibodies were detected 
      and reported using the LABScreen Single Antigen Bead assay with microbeads coated 
      with single HLA class I antigens. Pre-transplant and post-transplant data were 
      collected and the graft outcomes of 16 kidney graft recipients with antibodies to 
      HLA-C locus antigens were compared to the outcomes in 56 recipients with 
      antibodies to HLA-A or -B locus determined antigens. The one-year acute rejection 
      rate was 6% in those with donor-specific antibodies (DSA) to HLA-C locus antigens 
      and 20% in those with DSA to HLA-A or -B locus antigens. The graft survival rate 
      was 100% in those with DSA to HLA-C locus antigens and 95% in those with DSA to 
      HLA-A or -B locus antigens. None of the numerical differences were statistically 
      significant (p>0.05). The presence of circulating pre-transplant IgG antibodies 
      directed at kidney donor HLA-C locus antigens alone may not be associated with an 
      increased risk of acute rejection or a decreased graft survival rate. Our 
      observations support the concept that circulating pre-transplant IgG antibodies 
      directed at kidney donor HLA-C locus antigens alone do not negatively impact 
      kidney allograft outcomes and that the mean fluorescence intensities of the 
      antibodies directed at HLA-C locus alone should not be used to list unacceptable 
      HLA-C locus antigens for kidney allocation. A study with a larger cohort is 
      needed to investigate our hypothesis.
CI  - Copyright(c) 2017 by the Terasaki Research Institute.
FAU - Abuhelaiqa, Essa
AU  - Abuhelaiqa E
AD  - Department of Transplantation Medicine, New York Presbyterian Hospital/Weill 
      Cornell Medicine, New York, NY.
FAU - Friedlander, Rex
AU  - Friedlander R
AD  - Rogosin Institute, New York, NY.
FAU - Aull, Meredith
AU  - Aull M
AD  - Department of Transplantation Medicine, New York Presbyterian Hospital/Weill 
      Cornell Medicine, New York, NY.
FAU - Putheti, Prabhakar
AU  - Putheti P
AD  - Department of Transplantation Medicine, New York Presbyterian Hospital/Weill 
      Cornell Medicine, New York, NY.
AD  - Rogosin Institute, New York, NY.
FAU - Sharma, Vijay
AU  - Sharma V
AD  - Department of Transplantation Medicine, New York Presbyterian Hospital/Weill 
      Cornell Medicine, New York, NY.
AD  - Rogosin Institute, New York, NY.
FAU - Suthanthiran, Manikkam
AU  - Suthanthiran M
AD  - Department of Transplantation Medicine, New York Presbyterian Hospital/Weill 
      Cornell Medicine, New York, NY.
AD  - Rogosin Institute, New York, NY.
FAU - Dadhania, Darshana
AU  - Dadhania D
AD  - Department of Transplantation Medicine, New York Presbyterian Hospital/Weill 
      Cornell Medicine, New York, NY.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Transpl
JT  - Clinical transplants
JID - 8812419
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Allografts
MH  - Graft Rejection
MH  - *Graft Survival
MH  - *HLA Antigens
MH  - *HLA-A Antigens
MH  - Humans
MH  - Immunoglobulin G
MH  - *Isoantibodies
MH  - *Kidney Transplantation
MH  - Retrospective Studies
MH  - Tissue Donors
OTO - NOTNLM
OT  - HLA-C
OT  - donor-specific antibodies
OT  - pre-transplant
OT  - transplantation
EDAT- 2016/01/01 00:00
MHDA- 2018/07/24 06:00
CRDT- 2017/06/01 06:00
PHST- 2017/06/01 06:00 [entrez]
PHST- 2016/01/01 00:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PST - ppublish
SO  - Clin Transpl. 2016;32:83-91.