PMID- 28565788
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 13
IP  - 5
DP  - 2017 May
TI  - Immunosuppressive agents are associated with peptic ulcer bleeding.
PG  - 1927-1931
LID - 10.3892/etm.2017.4214 [doi]
AB  - Peptic ulcer bleeding can be fatal. Non-steroidal anti-inflammatory drugs 
      (NSAIDs), corticosteroids and immunosuppressive agents are administered for 
      long-term usage. The present study assessed the association between peptic ulcer 
      bleeding and administration of NSAIDs, corticosteroids and immunosuppressive 
      agents. Furthermore, the efficacy of lowering the risk of peptic ulcer bleeding 
      with proton pump inhibitors (PPI) and histamine 2 receptor antagonists (H2RA) was 
      evaluated. Medical records were retrospectively analyzed for patients subjected 
      to an upper gastrointestinal (GI) endoscopy performed at the National Hospital 
      Organization Shimoshizu Hospital (Yotsukaido, Japan) from October 2014 to 
      September 2015. During this period, a total of 1,023 patients underwent an upper 
      GI endoscopy. A total of 1,023 patients, including 431 males (age, 68.1+/-12.9 
      years) and 592 females (age, 66.4+/-12.3 years), who had been administered NSAIDs, 
      corticosteroids, immunosuppressive agents, PPIs and H2RAs, were respectively 
      enrolled. Endoscopic findings of the patients were reviewed and their data were 
      statistically analyzed. Logistic regression analysis was used to determine the 
      odds ratio of peptic ulcer bleeding for each medication; immunosuppressive agents 
      had an odds ratio of 5.83, which was larger than that for NSAIDs (4.77). The Wald 
      test was applied to confirm the correlation between immunosuppressive agents and 
      peptic ulcer bleeding. Furthermore, chi(2) tests were applied to the correlation 
      between peptic ulcer bleeding and administration of PPIs or H2RAs. 
      Immunosuppressive agents had the largest chi(2), and the P-value was 0.03. 
      Administration of PPIs was significantly correlated with non-peptic ulcer 
      bleeding (P=0.02); furthermore, a tendency toward non-peptic ulcer bleeding with 
      administration of H2RA was indicated, but it was not statistically significant 
      (P=0.12). In conclusion, immunosuppressive agents were correlated with peptic 
      ulcer bleeding and PPIs were effective at lowering the risk of peptic ulcer 
      bleeding.
FAU - Tomizawa, Minoru
AU  - Tomizawa M
AD  - Department of Gastroenterology, National Hospital Organization Shimoshizu 
      Hospital, Yotsukaido, Chiba 284-0003, Japan.
FAU - Shinozaki, Fuminobu
AU  - Shinozaki F
AD  - Department of Radiology, National Hospital Organization Shimoshizu Hospital, 
      Yotsukaido, Chiba 284-0003, Japan.
FAU - Hasegawa, Rumiko
AU  - Hasegawa R
AD  - Department of Surgery, National Hospital Organization Shimoshizu Hospital, 
      Yotsukaido, Chiba 284-0003, Japan.
FAU - Shirai, Yoshinori
AU  - Shirai Y
AD  - Department of Surgery, National Hospital Organization Shimoshizu Hospital, 
      Yotsukaido, Chiba 284-0003, Japan.
FAU - Motoyoshi, Yasufumi
AU  - Motoyoshi Y
AD  - Department of Neurology, National Hospital Organization Shimoshizu Hospital, 
      Yotsukaido, Chiba 284-0003, Japan.
FAU - Sugiyama, Takao
AU  - Sugiyama T
AD  - Department of Rheumatology, National Hospital Organization Shimoshizu Hospital, 
      Yotsukaido, Chiba 284-0003, Japan.
FAU - Yamamoto, Shigenori
AU  - Yamamoto S
AD  - Department of Pediatrics, National Hospital Organization Shimoshizu Hospital, 
      Yotsukaido, Chiba 284-0003, Japan.
FAU - Ishige, Naoki
AU  - Ishige N
AD  - Department of Neurosurgery, National Hospital Organization Shimoshizu Hospital, 
      Yotsukaido, Chiba 284-0003, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170309
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5443275
OTO - NOTNLM
OT  - Wald test
OT  - corticosteroids
OT  - histamine type 2 receptor antagonists
OT  - immunosuppressive agents
OT  - logistic regression analysis
OT  - nonsteroidal anti-inflammatory drugs
OT  - proton pump inhibitor
EDAT- 2017/06/02 06:00
MHDA- 2017/06/02 06:01
PMCR- 2017/03/09
CRDT- 2017/06/02 06:00
PHST- 2016/01/06 00:00 [received]
PHST- 2017/01/06 00:00 [accepted]
PHST- 2017/06/02 06:00 [entrez]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2017/06/02 06:01 [medline]
PHST- 2017/03/09 00:00 [pmc-release]
AID - ETM-0-0-4214 [pii]
AID - 10.3892/etm.2017.4214 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 May;13(5):1927-1931. doi: 10.3892/etm.2017.4214. Epub 2017 Mar 
      9.