PMID- 28565834
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 13
IP  - 5
DP  - 2017 May
TI  - Intravenous infusion umbilical cord-derived mesenchymal stem cell in primary 
      immune thrombocytopenia: A two-year follow-up.
PG  - 2255-2258
LID - 10.3892/etm.2017.4229 [doi]
AB  - Four patients with chronic refractory immune thrombocytopenic purpura (ITP) 
      received human umbilical cord-derived mesenchymal stem cells (hUC-MSCs). The 
      hUC-MSC dose was 5x10(7) to 1x10(8). Complete remission (CR) was achieved in 
      three patients in 12 months and one patient in 24 months. Three patients received 
      the second hUC-MSC transplantation with the same dose. The median time between 
      hUC-MSC transplantation and response was 12.5 days (range, 7-16). There were no 
      severe adverse events during and post hUC-MSC transplantation. During follow-up 
      (median, 17 months; range, 13-24) no other immunosuppressive drugs were used 
      post-first hUC-MSCs transplantation. In conclusion, hUC-MSC transplantation is a 
      reasonable salvage treatment in chronic refractory ITP. Prospective randomized 
      large-scale clinical trials are needed to further elucidate the efficacy of 
      hUC-MSCs transplantation therapy on ITP.
FAU - Wang, Xiaohua
AU  - Wang X
AD  - Department of Hematology, Siping Hospital of China Medical University, Siping, 
      Jilin 136000, P.R. China.
AD  - Jilin Tuhua Bioengineering Company Ltd., Siping, Jilin 136000, P.R. China.
FAU - Yin, Xiaoguang
AU  - Yin X
AD  - Jilin Tuhua Bioengineering Company Ltd., Siping, Jilin 136000, P.R. China.
FAU - Sun, Wei
AU  - Sun W
AD  - Department of Hematology, Siping Hospital of China Medical University, Siping, 
      Jilin 136000, P.R. China.
FAU - Bai, Jin
AU  - Bai J
AD  - Department of Hematology, Siping Hospital of China Medical University, Siping, 
      Jilin 136000, P.R. China.
FAU - Shen, Yawen
AU  - Shen Y
AD  - Department of Hematology, Siping Hospital of China Medical University, Siping, 
      Jilin 136000, P.R. China.
FAU - Ao, Qiang
AU  - Ao Q
AD  - Department of Tissue Engineering, China Medical University, Shenyang, Liaoning 
      110122, P.R. China.
FAU - Gu, Yongquan
AU  - Gu Y
AD  - Department of Vascular Surgery, Xuanwu Hospital of Capital Medical University, 
      Beijing 100053, P.R. China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Jilin Tuhua Bioengineering Company Ltd., Siping, Jilin 136000, P.R. China.
AD  - Key Laboratory of Tissue Engineering, Siping, Jilin 136000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170314
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5443306
OTO - NOTNLM
OT  - chronic immune thrombocytopenic purpura
OT  - efficacy
OT  - human umbilical cord-derived mesenchymal stem cells
OT  - intravenous infusion
OT  - safety
EDAT- 2017/06/02 06:00
MHDA- 2017/06/02 06:01
PMCR- 2017/03/14
CRDT- 2017/06/02 06:00
PHST- 2016/03/18 00:00 [received]
PHST- 2017/02/24 00:00 [accepted]
PHST- 2017/06/02 06:00 [entrez]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2017/06/02 06:01 [medline]
PHST- 2017/03/14 00:00 [pmc-release]
AID - ETM-0-0-4229 [pii]
AID - 10.3892/etm.2017.4229 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 May;13(5):2255-2258. doi: 10.3892/etm.2017.4229. Epub 2017 Mar 
      14.