PMID- 28566449
OWN - NLM
STAT- MEDLINE
DCOM- 20170828
LR  - 20170828
IS  - 1470-8736 (Electronic)
IS  - 0143-5221 (Linking)
VI  - 131
IP  - 12
DP  - 2017 Jun 1
TI  - The role of perivascular innervation and neurally mediated vasoreactivity in the 
      pathophysiology of Alzheimer's disease.
PG  - 1207-1214
LID - 10.1042/CS20160769 [doi]
AB  - Neuronal death is a hallmark of Alzheimer's disease (AD) and considerable work 
      has been done to understand how the loss of interconnectivity between neurons 
      contributes to the associated dementia. Often overlooked however, is how the loss 
      of neuronal innervation of blood vessels, termed perivascular innervation, may 
      also contribute to the pathogenesis of AD. There is now considerable evidence 
      supporting a crucial role for the neurovascular unit (NVU) in mediating the 
      clearance of the beta-amyloid (Abeta) peptide, one of the main pathological 
      constituents of AD, from the brain. Moreover, efficient removal appears to be 
      dependent on the communication of cells within the NVU to maintain adequate 
      vascular tone and pulsatility. This review summarizes the composition of the NVU, 
      including the sources of perivascular innervation and how the NVU mediates Abeta 
      clearance from the brain. It also explores evidence supporting the hypothesis 
      that loss of neurally mediated vasoreactivity contributes to Abeta pathology in the 
      AD brain.
CI  - (c) 2017 The Author(s); published by Portland Press Limited on behalf of the 
      Biochemical Society.
FAU - Nizari, Shereen
AU  - Nizari S
AD  - School of Life, Health and Chemical Sciences, Faculty of Science, Technology, 
      Engineering and Mathematics, The Open University, Milton Keynes, MK7 6AA, U.K.
FAU - Romero, Ignacio A
AU  - Romero IA
AD  - School of Life, Health and Chemical Sciences, Faculty of Science, Technology, 
      Engineering and Mathematics, The Open University, Milton Keynes, MK7 6AA, U.K.
FAU - Hawkes, Cheryl A
AU  - Hawkes CA
AD  - School of Life, Health and Chemical Sciences, Faculty of Science, Technology, 
      Engineering and Mathematics, The Open University, Milton Keynes, MK7 6AA, U.K. 
      cheryl.hawkes@open.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Amyloid beta-Peptides)
SB  - IM
MH  - Alzheimer Disease/metabolism/pathology/*physiopathology
MH  - Amyloid beta-Peptides/*metabolism
MH  - Animals
MH  - Blood Vessels/*innervation
MH  - Brain/*blood supply/metabolism/pathology/physiopathology
MH  - Cerebrovascular Circulation
MH  - *Hemodynamics
MH  - Humans
MH  - *Nerve Degeneration
MH  - Neurons/pathology
MH  - *Neurovascular Coupling
MH  - *Plaque, Amyloid
OTO - NOTNLM
OT  - Alzheimers disease
OT  - blood vessel
OT  - innervation
OT  - vasoreactivity
EDAT- 2017/06/02 06:00
MHDA- 2017/08/29 06:00
CRDT- 2017/06/02 06:00
PHST- 2016/12/20 00:00 [received]
PHST- 2017/02/22 00:00 [revised]
PHST- 2017/02/24 00:00 [accepted]
PHST- 2017/06/02 06:00 [entrez]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2017/08/29 06:00 [medline]
AID - CS20160769 [pii]
AID - 10.1042/CS20160769 [doi]
PST - ppublish
SO  - Clin Sci (Lond). 2017 Jun 1;131(12):1207-1214. doi: 10.1042/CS20160769.