PMID- 28566601
OWN - NLM
STAT- MEDLINE
DCOM- 20171108
LR  - 20181202
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 56
IP  - 11
DP  - 2017
TI  - Challenging Differential Diagnosis of Hypergastremia and Hyperglucagonemia with 
      Chronic Renal Failure: Report of a Case with Multiple Endocrine Neoplasia Type 1.
PG  - 1375-1381
LID - 10.2169/internalmedicine.56.7230 [doi]
AB  - A 53-year-old woman developed end-stage renal failure during a 15-year clinical 
      course of primary hyperparathyroidism and was referred to our hospital for 
      evaluation of suspected multiple endocrine neoplasia type 1 (MEN1). Genetic 
      testing revealed a novel deletion mutation at codon 467 in exon 10 of the MEN1 
      gene. Systemic and selective arterial calcium injection (SACI) testing revealed 
      hyperglucagonemia and hypergastrinemia with positive gastrin responses. A 
      pathological examination revealed glucagonoma and a lymph node gastrinoma. The 
      findings in this case indicate the importance of early diagnosis of MEN1 and 
      demonstrate the utility of systemic and SACI testing in renal failure cases.
FAU - Murakami, Takaaki
AU  - Murakami T
AD  - Department of Diabetes and Endocrinology, Osaka Red Cross Hospital, Japan.
FAU - Usui, Takeshi
AU  - Usui T
AD  - Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 
      Japan.
FAU - Nakamoto, Yuji
AU  - Nakamoto Y
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of 
      Medicine, Kyoto University, Japan.
FAU - Nakajima, Akio
AU  - Nakajima A
AD  - Department of Surgery, Osaka Red Cross Hospital, Japan.
FAU - Mochida, Yuki
AU  - Mochida Y
AD  - Department of Surgery, Osaka Red Cross Hospital, Japan.
FAU - Saito, Sumio
AU  - Saito S
AD  - Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Japan.
FAU - Shibayama, Takahiro
AU  - Shibayama T
AD  - Department of Pathology, Osaka Red Cross Hospital, Japan.
FAU - Yamazaki, Nobuhisa
AU  - Yamazaki N
AD  - Department of Respiratory Surgery, Osaka Red Cross Hospital, Japan.
FAU - Hatoko, Tomonobu
AU  - Hatoko T
AD  - Department of Diabetes and Endocrinology, Osaka Red Cross Hospital, Japan.
FAU - Kato, Tomoko
AU  - Kato T
AD  - Department of Diabetes and Endocrinology, Osaka Red Cross Hospital, Japan.
FAU - Yonemitsu, Shin
AU  - Yonemitsu S
AD  - Department of Diabetes and Endocrinology, Osaka Red Cross Hospital, Japan.
FAU - Muro, Seiji
AU  - Muro S
AD  - Department of Diabetes and Endocrinology, Osaka Red Cross Hospital, Japan.
FAU - Oki, Shogo
AU  - Oki S
AD  - Department of Diabetes and Endocrinology, Osaka Red Cross Hospital, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170601
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Diagnosis, Differential
MH  - Female
MH  - Gastrinoma/diagnosis
MH  - Glucagonoma/diagnosis
MH  - Humans
MH  - Kidney Failure, Chronic/diagnosis
MH  - Lymph Nodes/pathology
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/genetics/*physiopathology
MH  - Pancreatic Neoplasms/diagnosis
MH  - Proto-Oncogene Proteins
MH  - Renal Insufficiency, Chronic/genetics
PMC - PMC5498202
OTO - NOTNLM
OT  - AIMAH
OT  - MEN1
OT  - calcium test
OT  - gastrinoma
OT  - glucagonoma
OT  - renal failure
EDAT- 2017/06/02 06:00
MHDA- 2017/11/09 06:00
PMCR- 2017/06/01
CRDT- 2017/06/02 06:00
PHST- 2017/06/02 06:00 [entrez]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2017/11/09 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - 10.2169/internalmedicine.56.7230 [doi]
PST - ppublish
SO  - Intern Med. 2017;56(11):1375-1381. doi: 10.2169/internalmedicine.56.7230. Epub 
      2017 Jun 1.