PMID- 28566735
OWN - NLM
STAT- MEDLINE
DCOM- 20181213
LR  - 20181213
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 May 31
TI  - Interaction processes of ciprofloxacin with graphene oxide and reduced graphene 
      oxide in the presence of montmorillonite in simulated gastrointestinal fluids.
PG  - 2588
LID - 10.1038/s41598-017-02620-4 [doi]
LID - 2588
AB  - This study investigated the interaction processes of ciprofloxacin (CIP) with 
      graphene oxide (GO) and reduced GO (rGO) in presence of montmorillonite (Mont) in 
      simulated gastrointestinal fluids. The order of CIP adsorption affinity was 
      rGO+Mont > GO+Mont > rGO+Mont+pepsin > rGO > GO+Mont+pepsin > Mont > Mont+pepsin > GO > rGO+pepsin > GO+pepsin 
      in simulated gastric fluid. Mont enhanced the adsorption of CIP on GO and rGO due 
      to hydrated Si species coating on GO and rGO in the simulated gastric fluid. 
      Meanwhile, pi-pi interaction between CIP and graphene caused the great shift of two 
      cyclopropyl CH(2) and one cyclopropyl in CIP molecules. And GO, rGO, and Mont 
      interacted mainly with CIP by COOH groups. CIP and pepsin molecules could 
      intercalate and increase the basal spacing of Mont as well. After the various 
      interaction systems of adsorbent-adsorbate transferring to the simulated 
      intestinal fluid, CIP was continuously adsorbed by GO and rGO. In addition, 
      adsorbed CIP was released from Mont into the solution through electrostatic 
      repulsion. The decrease ratio of CIP was the lowest in the GO/rGO+Mont+pepsin 
      systems. Therefore, the mixture of Mont and GO/rGO decreased the CIP 
      concentration in gastrointestinal fluid to weaken further antibiotic activity of 
      CIP.
FAU - Ma, Shuai
AU  - Ma S
AD  - School of Energy & Environmental Engineering, University of Science and 
      Technology Beijing, 30 Xueyuan Road, 100083, Beijing, China.
AD  - Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, 
      University of Science and Technology Beijing, 30 Xueyuan Road, 100083, Beijing, 
      China.
FAU - Si, Yang
AU  - Si Y
AD  - PPSM, CNRS UMR 8531, ENS-Cachan, 61 av President Wilson, 94230, Cachan, France.
FAU - Wang, Fei
AU  - Wang F
AD  - School of Energy & Environmental Engineering, University of Science and 
      Technology Beijing, 30 Xueyuan Road, 100083, Beijing, China. wangfei@ustb.edu.cn.
AD  - Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, 
      University of Science and Technology Beijing, 30 Xueyuan Road, 100083, Beijing, 
      China. wangfei@ustb.edu.cn.
FAU - Su, Lei
AU  - Su L
AUID- ORCID: 0000-0001-5342-1552
AD  - Research Center for Bioengineering and Sensing Technology, School of Chemistry 
      and Biological Engineering, University of Science and Technology Beijing, 100083, 
      Beijing, China.
FAU - Xia, CongCong
AU  - Xia C
AD  - School of Energy & Environmental Engineering, University of Science and 
      Technology Beijing, 30 Xueyuan Road, 100083, Beijing, China.
AD  - Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, 
      University of Science and Technology Beijing, 30 Xueyuan Road, 100083, Beijing, 
      China.
FAU - Yao, Jun
AU  - Yao J
AD  - School of Water Resource and Environmental Engineering, Sino-Hungarian Joint 
      Laboratory of Environmental Science and Health, China University of Geosciences 
      (Beijing), 29 Xueyuan Road, Haidian District, 100083, Beijing, China. 
      yaojun@ustb.edu.cn.
FAU - Chen, Huilun
AU  - Chen H
AD  - School of Energy & Environmental Engineering, University of Science and 
      Technology Beijing, 30 Xueyuan Road, 100083, Beijing, China.
AD  - Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, 
      University of Science and Technology Beijing, 30 Xueyuan Road, 100083, Beijing, 
      China.
FAU - Liu, Xingyu
AU  - Liu X
AD  - National Engineering Laboratory of Biohydrometallurgy, General Research Institute 
      for Nonferrous Metals, 100088, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170531
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Organic Chemicals)
RN  - 0 (Water Pollutants, Chemical)
RN  - 0 (graphene oxide)
RN  - 1302-78-9 (Bentonite)
RN  - 5E8K9I0O4U (Ciprofloxacin)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Adsorption/drug effects
MH  - Bentonite/chemistry/*pharmacology
MH  - Body Fluids/drug effects/metabolism
MH  - Ciprofloxacin/chemistry/*pharmacology
MH  - Gastrointestinal Tract/chemistry/*drug effects/metabolism
MH  - Graphite/chemistry/*pharmacology
MH  - Humans
MH  - Organic Chemicals/adverse effects
MH  - Static Electricity
MH  - Water Pollutants, Chemical/adverse effects
PMC - PMC5451422
COIS- The authors declare that they have no competing interests.
EDAT- 2017/06/02 06:00
MHDA- 2018/12/14 06:00
PMCR- 2017/05/31
CRDT- 2017/06/02 06:00
PHST- 2017/02/13 00:00 [received]
PHST- 2017/04/13 00:00 [accepted]
PHST- 2017/06/02 06:00 [entrez]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2018/12/14 06:00 [medline]
PHST- 2017/05/31 00:00 [pmc-release]
AID - 10.1038/s41598-017-02620-4 [pii]
AID - 2620 [pii]
AID - 10.1038/s41598-017-02620-4 [doi]
PST - epublish
SO  - Sci Rep. 2017 May 31;7(1):2588. doi: 10.1038/s41598-017-02620-4.