PMID- 28566897
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20181113
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 23
IP  - 18
DP  - 2017 May 14
TI  - Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory 
      bowel disease.
PG  - 3356-3366
LID - 10.3748/wjg.v23.i18.3356 [doi]
AB  - AIM: To investigate the effect of a low-FODMAP diet on irritable bowel syndrome 
      (IBS)-like symptoms in patients with inflammatory bowel disease (IBD). METHODS: 
      This was a randomised controlled open-label trial of patients with IBD in 
      remission or with mild-to-moderate disease and coexisting IBS-like symptoms (Rome 
      III) randomly assigned to a Low-FODMAP diet (LFD) or a normal diet (ND) for 6 wk 
      between June 2012 and December 2013. Patients completed the IBS symptom severity 
      system (IBS-SSS) and short IBD quality of life questionnaire (SIBDQ) at weeks 0 
      and 6. The primary end-point was response rates (at least 50-point reduction) in 
      IBS-SSS at week 6 between groups; secondary end-point was the impact on quality 
      of life. RESULTS: Eighty-nine patients, 67 (75%) women, median age 40, range 
      20-70 years were randomised: 44 to LFD group and 45 to ND, from which 78 patients 
      completed the study period and were included in the final analysis (37 LFD and 41 
      ND). There was a significantly larger proportion of responders in the LFD group 
      (n = 30, 81%) than in the ND group (n = 19, 46%); (OR = 5.30; 95%CI: 1.81-15.55, 
      P < 0.01). At week 6, the LFD group showed a significantly lower median IBS-SSS 
      (median 115; inter-quartile range [IQR] 33-169) than ND group (median 170, IQR 
      91-288), P = 0.02. Furthermore, the LFD group had a significantly greater 
      increase in SIBDQ (median 60, IQR 51-65) than the ND group (median 50, IQR 
      39-60), P < 0.01. CONCLUSION: In a prospective study, a low-FODMAP diet reduced 
      IBS-like symptoms and increased quality of life in patients with IBD in 
      remission.
FAU - Pedersen, Natalia
AU  - Pedersen N
AD  - Natalia Pedersen, Department of Gastroenterology, Slagelse Hospital, 4200 
      Slagelse, Denmark.
FAU - Ankersen, Dorit Vedel
AU  - Ankersen DV
AD  - Natalia Pedersen, Department of Gastroenterology, Slagelse Hospital, 4200 
      Slagelse, Denmark.
FAU - Felding, Maria
AU  - Felding M
AD  - Natalia Pedersen, Department of Gastroenterology, Slagelse Hospital, 4200 
      Slagelse, Denmark.
FAU - Wachmann, Henrik
AU  - Wachmann H
AD  - Natalia Pedersen, Department of Gastroenterology, Slagelse Hospital, 4200 
      Slagelse, Denmark.
FAU - Vegh, Zsuzsanna
AU  - Vegh Z
AD  - Natalia Pedersen, Department of Gastroenterology, Slagelse Hospital, 4200 
      Slagelse, Denmark.
FAU - Molzen, Line
AU  - Molzen L
AD  - Natalia Pedersen, Department of Gastroenterology, Slagelse Hospital, 4200 
      Slagelse, Denmark.
FAU - Burisch, Johan
AU  - Burisch J
AD  - Natalia Pedersen, Department of Gastroenterology, Slagelse Hospital, 4200 
      Slagelse, Denmark.
FAU - Andersen, Jens Rikardt
AU  - Andersen JR
AD  - Natalia Pedersen, Department of Gastroenterology, Slagelse Hospital, 4200 
      Slagelse, Denmark.
FAU - Munkholm, Pia
AU  - Munkholm P
AD  - Natalia Pedersen, Department of Gastroenterology, Slagelse Hospital, 4200 
      Slagelse, Denmark.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Disaccharides)
RN  - 0 (Monosaccharides)
RN  - 0 (Oligosaccharides)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - C-Reactive Protein/metabolism
MH  - *Diet
MH  - Disaccharides/chemistry
MH  - Female
MH  - Fermentation
MH  - Humans
MH  - Inflammatory Bowel Diseases/*diagnosis/*therapy
MH  - Internet
MH  - Irritable Bowel Syndrome/*diagnosis/*therapy
MH  - Male
MH  - Middle Aged
MH  - Monosaccharides/chemistry
MH  - Oligosaccharides/chemistry
MH  - Patient Compliance
MH  - Prospective Studies
MH  - Quality of Life
MH  - Remission Induction
MH  - Young Adult
PMC - PMC5434443
OTO - NOTNLM
OT  - Inflammatory bowel disease
OT  - Irritable bowel syndrome
OT  - Low-FODMAP diet
OT  - Web-based management
COIS- Conflict-of-interest statement: The authors declare no conflicts of interest.
EDAT- 2017/06/02 06:00
MHDA- 2018/04/17 06:00
PMCR- 2017/05/14
CRDT- 2017/06/02 06:00
PHST- 2016/11/15 00:00 [received]
PHST- 2017/01/24 00:00 [revised]
PHST- 2017/03/20 00:00 [accepted]
PHST- 2017/06/02 06:00 [entrez]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
PHST- 2017/05/14 00:00 [pmc-release]
AID - 10.3748/wjg.v23.i18.3356 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2017 May 14;23(18):3356-3366. doi: 
      10.3748/wjg.v23.i18.3356.