PMID- 28567424
OWN - NLM
STAT- MEDLINE
DCOM- 20180307
LR  - 20201209
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - Effect of Naringenin, Quercetin, and Sesamin on Xenobiotica-Metabolizing CYP1A 
      and CYP3A in Mice Offspring after Maternal Exposure to Persistent Organic 
      Pollutants.
PG  - 8472312
LID - 10.1155/2017/8472312 [doi]
LID - 8472312
AB  - The aim of the present study was to evaluate in vitro effects of dietary 
      phytochemicals naringenin, quercetin, and sesamin on the activities of ethoxy- 
      (EROD; CYP1A) and benzyloxy- (BROD; CYP3A) resorufin O-dealkylases after the 
      exposure to the cocktail of persistent organic pollutants (POPs). CD-1 mice were 
      exposed from weaning, through gestation and lactation to a defined mixture of 
      POPs. Hepatic microsomes were prepared from their female offspring at postnatal 
      day 42. Hepatic EROD and BROD activity were evaluated in the presence of 
      quercetin, naringenin, and sesamin at nine concentrations from 5 to 100000 nM. 
      EROD activity was strongly inhibited by quercetin with Ki values from 1.7 to 
      2.6 muM. BROD activity was inhibited by quercetin with Ki values from 64.9 to 
      75.3 muM and naringenin with Ki values from 39.3 to 45.8 muM. The IC(50) and Ki 
      values did not differ between the groups of mice with different levels of POPs 
      exposure in any of the experimental sets. Sesamin did not inhibit either EROD or 
      BROD. We concluded that the interactions of quercetin and naringenin with CYP1A 
      and CYP3A in mice liver were not affected by the levels of POPs exposure.
FAU - Pilipenko, Nadezhda
AU  - Pilipenko N
AD  - Department of Molecular Sciences, Swedish University of Agricultural Sciences, 
      P.O. Box 7015, 750 07 Uppsala, Sweden.
FAU - Ropstad, Erik
AU  - Ropstad E
AD  - Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine 
      and Biosciences, Norwegian University of Life Sciences, P.O. 8146 Dep., 0033 
      Oslo, Norway.
FAU - Halsne, Ruth
AU  - Halsne R
AD  - Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine 
      and Biosciences, Norwegian University of Life Sciences, P.O. 8146 Dep., 0033 
      Oslo, Norway.
FAU - Zamaratskaia, Galia
AU  - Zamaratskaia G
AUID- ORCID: 0000-0003-0926-4849
AD  - Department of Molecular Sciences, Swedish University of Agricultural Sciences, 
      P.O. Box 7015, 750 07 Uppsala, Sweden.
AD  - Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of 
      Aquaculture and Biodiversity of Hydrocenoses, University of South Bohemia in 
      Ceske Budejovice, Zatisi 728/II, 389 25 Vodnany, Czech Republic.
LA  - eng
PT  - Journal Article
DEP - 20170508
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Air Pollutants)
RN  - 0 (Dioxoles)
RN  - 0 (Flavanones)
RN  - 0 (Lignans)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - 9IKM0I5T1E (Quercetin)
RN  - EC 1.14.14.1 (CYP3A protein, mouse)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP3A)
RN  - EC 1.14.14.1 (Cytochrome P450 Family 1)
RN  - HN5425SBF2 (naringenin)
RN  - S7946O4P76 (sesamin)
SB  - IM
MH  - Air Pollutants/*toxicity
MH  - Animals
MH  - Cytochrome P-450 CYP3A
MH  - Cytochrome P-450 Enzyme System/*metabolism
MH  - Cytochrome P450 Family 1/*metabolism
MH  - Dioxoles/*pharmacology
MH  - Female
MH  - Flavanones/*pharmacology
MH  - Lignans/*pharmacology
MH  - Maternal Exposure/*adverse effects
MH  - Mice
MH  - Microsomes, Liver/enzymology/pathology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*enzymology/pathology
MH  - Quercetin/*pharmacology
PMC - PMC5439065
EDAT- 2017/06/02 06:00
MHDA- 2018/03/08 06:00
PMCR- 2017/05/08
CRDT- 2017/06/02 06:00
PHST- 2017/01/05 00:00 [received]
PHST- 2017/03/17 00:00 [revised]
PHST- 2017/04/18 00:00 [accepted]
PHST- 2017/06/02 06:00 [entrez]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2018/03/08 06:00 [medline]
PHST- 2017/05/08 00:00 [pmc-release]
AID - 10.1155/2017/8472312 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:8472312. doi: 10.1155/2017/8472312. Epub 2017 May 8.