PMID- 28567553
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20181113
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 32
IP  - 11
DP  - 2017 Nov
TI  - Plasma levels of sRANKL and OPG are associated with atherogenic cytokines in 
      patients with intermediate cardiovascular risk.
PG  - 1304-1313
LID - 10.1007/s00380-017-0998-z [doi]
AB  - Osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand (RANKL) 
      are regulators of bone remodeling, but are also considered to play important 
      roles in coronary artery disease (CAD). This study evaluated potential 
      associations of soluble (s) RANKL and OPG with atherosclerosis-relevant 
      cytokines. Blood was collected from 414 individuals who presented to our hospital 
      with intermediate likelihood for CAD for further examination. Plasma 
      concentrations of total sRANKL, OPG, and 20 cytokines were measured using 
      sandwich-type enzyme-linked immunoassays (ELISAs; OPG and sRANKL) and Luminex 
      laser-based fluorescence analysis and correlated with each other. The plasma 
      levels of interferon-gamma (IFN-gamma) and the T-helper cell 2 cytokines interleukin-4 
      (IL-4) and IL-13 showed a positive correlation with sRANKL. The association with 
      sRANKL levels was negative for IFN-gamma-induced protein-10 (IP-10) and monocyte 
      chemotactic protein-1 (MCP-1). The strongest independent association with sRANKL 
      in multivariable analyses was found for IFN-gamma (positive) and IP-10 (negative), 
      while IL-13 showed a positive and independent association with OPG plasma levels. 
      OPG and sRANKL plasma levels correlate strongly and independently with specific 
      circulating atherosclerosis-related cytokines in patients with intermediate 
      cardiovascular risk.
FAU - Raaz-Schrauder, Dorette
AU  - Raaz-Schrauder D
AUID- ORCID: 0000-0003-1840-5850
AD  - Friedrich-Alexander University Erlangen-Nurnberg (FAU), Department of Cardiology 
      and Angiology, Erlangen University Hospital, Ulmenweg 18, 91054, Erlangen, 
      Germany. Dorette.Raaz@uk-erlangen.de.
FAU - Schrauder, Michael G
AU  - Schrauder MG
AD  - Friedrich-Alexander University Erlangen-Nurnberg (FAU), Department of Obstetrics 
      and Gynecology, Erlangen University Hospital, Comprehensive Cancer Center 
      Erlangen-EMN, Erlangen, Germany.
FAU - Stumpf, Christian
AU  - Stumpf C
AD  - Friedrich-Alexander University Erlangen-Nurnberg (FAU), Department of Cardiology 
      and Angiology, Erlangen University Hospital, Ulmenweg 18, 91054, Erlangen, 
      Germany.
FAU - Lewczuk, Piotr
AU  - Lewczuk P
AD  - Friedrich-Alexander University Erlangen-Nurnberg(FAU), Department of Psychiatry 
      and Psychotherapy, Erlangen, University Hospital, Erlangen, Germany.
AD  - Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 
      Bialystok, Poland.
AD  - Department of Biochemical Diagnostics, University Hospital of Bialystok, 
      Bialystok, Poland.
FAU - Kilian, Tobias
AU  - Kilian T
AD  - Friedrich-Alexander University Erlangen-Nurnberg (FAU), Department of Cardiology 
      and Angiology, Erlangen University Hospital, Ulmenweg 18, 91054, Erlangen, 
      Germany.
FAU - Dietel, Barbara
AU  - Dietel B
AD  - Friedrich-Alexander University Erlangen-Nurnberg (FAU), Department of Cardiology 
      and Angiology, Erlangen University Hospital, Ulmenweg 18, 91054, Erlangen, 
      Germany.
FAU - Garlichs, Christoph D
AU  - Garlichs CD
AD  - Diakonissenkrankenhaus, Flensburg, Germany.
FAU - Schlundt, Christian
AU  - Schlundt C
AD  - Friedrich-Alexander University Erlangen-Nurnberg (FAU), Department of Cardiology 
      and Angiology, Erlangen University Hospital, Ulmenweg 18, 91054, Erlangen, 
      Germany.
FAU - Achenbach, Stephan
AU  - Achenbach S
AD  - Friedrich-Alexander University Erlangen-Nurnberg (FAU), Department of Cardiology 
      and Angiology, Erlangen University Hospital, Ulmenweg 18, 91054, Erlangen, 
      Germany.
FAU - Klinghammer, Lutz
AU  - Klinghammer L
AD  - Friedrich-Alexander University Erlangen-Nurnberg (FAU), Department of Cardiology 
      and Angiology, Erlangen University Hospital, Ulmenweg 18, 91054, Erlangen, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20170531
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Osteoprotegerin)
RN  - 0 (RANK Ligand)
RN  - 0 (TNFSF11 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atherosclerosis/*blood/epidemiology
MH  - Biomarkers/blood
MH  - Coronary Artery Disease/*blood/epidemiology
MH  - Cytokines/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Morbidity/trends
MH  - Osteoprotegerin/*blood
MH  - RANK Ligand/*blood
MH  - *Risk Assessment
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Cytokines
OT  - Inflammation
OT  - Osteoprotegerin (OPG)
OT  - Receptor activator of nuclear factor-kappaB ligand (RANKL)
EDAT- 2017/06/02 06:00
MHDA- 2018/04/24 06:00
CRDT- 2017/06/02 06:00
PHST- 2016/12/21 00:00 [received]
PHST- 2017/05/26 00:00 [accepted]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/06/02 06:00 [entrez]
AID - 10.1007/s00380-017-0998-z [pii]
AID - 10.1007/s00380-017-0998-z [doi]
PST - ppublish
SO  - Heart Vessels. 2017 Nov;32(11):1304-1313. doi: 10.1007/s00380-017-0998-z. Epub 
      2017 May 31.