PMID- 28569222
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20211204
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 19
IP  - 1
DP  - 2017 May 31
TI  - Is the current ASAS expert definition of a positive family history useful in 
      identifying axial spondyloarthritis? Results from the SPACE and DESIR cohorts.
PG  - 118
LID - 10.1186/s13075-017-1335-8 [doi]
LID - 118
AB  - BACKGROUND: The Assessment of SpondyloArthritis international Society (ASAS) 
      definition of a positive family history (PFH) of spondyloarthritis (SpA) includes 
      the following diseases in first- or second-degree relatives: ankylosing 
      spondylitis (AS), acute anterior uveitis (AAU), reactive arthritis (ReA), 
      inflammatory bowel disease (IBD), and psoriasis. However, it is not known if a 
      PFH for each of these diseases contributes to making a diagnosis of axSpA, 
      sacroiliitis on imaging, or fulfilling the ASAS criteria in patients presenting 
      with chronic back pain (CBP). Therefore, the aim of this study was to assess 
      which SpA diseases in family members are associated with human leukocyte antigen 
      B27 (HLA-B27) and axial spondyloarthritis (axSpA) in CBP patients. METHODS: CBP 
      patients suspected of axSpA from the SPACE (n = 438) and the DESIR (n = 647) 
      cohort were asked about the presence of SpA diseases in first- or second-degree 
      relatives (AS, AAU, ReA, IBD, and psoriasis). The associations between a PFH and 
      HLA-B27, sacroiliitis on imaging (magnetic resonance imaging (MRI) or 
      radiographs), axSpA diagnosis, and ASAS classification in CBP patients were 
      assessed. RESULTS: In the SPACE and the DESIR cohort, a PFH of AS (odds ratio 
      (OR) 5.9 (95% confidence interval (CI) 3.5-9.9), and OR 3.3 (95% CI 2.1-5.2)) and 
      a PFH of AAU (OR 9.8 (95% CI 3.3-28.9) and OR 21.6 (95% CI 2.9-160.1)) were 
      significantly associated with presence of HLA-B27. Furthermore, in both cohorts a 
      PFH of AS and a PFH of AAU were positively associated with fulfilment of the ASAS 
      criteria, but not with sacroiliitis on imaging. In SPACE but not in DESIR a PFH 
      of AAU was positively associated with axSpA diagnosis. In both cohorts a PFH of 
      ReA, IBD, or psoriasis was not positively associated with HLA-B27 positivity, 
      sacroiliitis on imaging, axSpA diagnosis, or meeting the ASAS criteria for axSpA. 
      CONCLUSIONS: In our cohorts, a PFH of AS or AAU is useful for case-finding of 
      axSpA as this is correlated with HLA-B27 carriership. However, as a PFH of ReA, 
      IBD, or psoriasis does not contribute to identifying axSpA in CBP patients, these 
      data suggest that the widely used ASAS definition of a PFH of SpA should be 
      updated. TRIAL REGISTRATION: Trial registration number, NCT01648907 . Registered 
      on 20 July 2012.
FAU - Ez-Zaitouni, Zineb
AU  - Ez-Zaitouni Z
AD  - Department of Rheumatology, Leiden University Medical Center, P.O. Box 9600, 2300 
      RC, Leiden, The Netherlands. z.ez-zaitouni@lumc.nl.
FAU - Hilkens, Andrea
AU  - Hilkens A
AD  - Department of Rheumatology, Leiden University Medical Center, P.O. Box 9600, 2300 
      RC, Leiden, The Netherlands.
FAU - Gossec, Laure
AU  - Gossec L
AD  - Sorbonne Universites, UPMC Univ Paris 06, GRC-08, Paris, France.
AD  - Rheumatology Department, Pitie-Salpetriere Hospital, AP-HP, Paris, France.
FAU - Berg, Inger Jorid
AU  - Berg IJ
AD  - Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
FAU - Landewe, Robert
AU  - Landewe R
AD  - Department of Clinical Immunology and Rheumatology, Amsterdam Medical Center, 
      Amsterdam, The Netherlands.
FAU - Ramonda, Roberta
AU  - Ramonda R
AD  - Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, 
      Italy.
FAU - Dougados, Maxime
AU  - Dougados M
AD  - Paris Descartes University, Hopital Cochin, Assistance Publique-Hopitaux de 
      Paris, INSERM (U1153): Epidemiologie Clinique et Biostatistiques, PRES Sorbonne 
      Paris-Cite, Paris, France.
FAU - van der Heijde, Desiree
AU  - van der Heijde D
AD  - Department of Rheumatology, Leiden University Medical Center, P.O. Box 9600, 2300 
      RC, Leiden, The Netherlands.
FAU - van Gaalen, Floris
AU  - van Gaalen F
AD  - Department of Rheumatology, Leiden University Medical Center, P.O. Box 9600, 2300 
      RC, Leiden, The Netherlands.
LA  - eng
SI  - ClinicalTrials.gov/NCT01648907
PT  - Journal Article
DEP - 20170531
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (PHB2 protein, human)
RN  - 0 (Prohibitins)
SB  - IM
MH  - Adult
MH  - Back Pain/*etiology
MH  - Cohort Studies
MH  - Female
MH  - HLA-B27 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Prohibitins
MH  - Spondylarthritis/complications/*diagnosis/*genetics
PMC - PMC5452625
OTO - NOTNLM
OT  - Acute anterior uveitis
OT  - Ankylosing spondylitis
OT  - Axial spondyloarthritis
OT  - Chronic back pain
OT  - Diagnostic work-up
OT  - Family history
OT  - IBD
OT  - Psoriasis
OT  - Reactive arthritis
EDAT- 2017/06/02 06:00
MHDA- 2018/01/03 06:00
PMCR- 2017/05/31
CRDT- 2017/06/02 06:00
PHST- 2017/03/17 00:00 [received]
PHST- 2017/05/15 00:00 [accepted]
PHST- 2017/06/02 06:00 [entrez]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2017/05/31 00:00 [pmc-release]
AID - 10.1186/s13075-017-1335-8 [pii]
AID - 1335 [pii]
AID - 10.1186/s13075-017-1335-8 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2017 May 31;19(1):118. doi: 10.1186/s13075-017-1335-8.