PMID- 28569739
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2155-384X (Print)
IS  - 2155-384X (Electronic)
IS  - 2155-384X (Linking)
VI  - 8
IP  - 6
DP  - 2017 Jun 1
TI  - Endoscopic-Guided Measurement of Mucosal Admittance can Discriminate 
      Gastroesophageal Reflux Disease from Functional Heartburn.
PG  - e94
LID - 10.1038/ctg.2017.22 [doi]
AB  - OBJECTIVES: A novel catheter that can measure mucosal admittance (MA), the 
      inverse of impedance, was developed recently. In this pilot study, we aimed to 
      clarify the usefulness of measuring MA for diagnosing gastroesophageal reflux 
      disease (GERD). METHODS: We conducted two prospective studies. In the first 
      study, esophageal MA was evaluated in 120 participants (24 with erosive 
      esophagitis, 82 with heartburn but non-erosive esophagitis, and 14 healthy 
      volunteers) and compared with the endoscopic findings. In the second study, 
      multichannel intraluminal impedance combined with pH (MII-pH) tests was conducted 
      followed by an MA measurement in 33 patients with non-erosive esophagitis and 
      proton pump inhibitor (PPI)-refractory heartburn. Based on the MII-pH test 
      results, patients were divided into GERD or functional heartburn (FH). MA was 
      compared between the GERD and FH groups and also compared with the baseline 
      impedance (BI) and acid exposure time (AET). RESULTS: Median MA at the distal 
      esophagus was significantly higher in patients with erosive esophagitis compared 
      with that in patients with non-erosive esophagitis and healthy volunteers (46.8, 
      13.1 and 6.5, respectively, P<0.01). In patients with PPI-refractory heartburn, 
      the median MA at the distal esophagus was significantly higher in patients with 
      GERD than those with FH (19.3 vs. 7.2, P<0.05). There was a negative correlation 
      between MA and BI, and a positive correlation between MA and AET at the distal 
      esophagus (r=-0.46 and r=0.53, P<0.05). CONCLUSIONS: Real-time measurement of MA 
      is useful to distinguish GERD from non-GERD.
FAU - Matsumura, Tomoaki
AU  - Matsumura T
AD  - Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
FAU - Ishigami, Hideaki
AU  - Ishigami H
AD  - Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
FAU - Fujie, Mai
AU  - Fujie M
AD  - Department of Clinical Engineering Center, Chiba University Hospital, Chiba, 
      Japan.
FAU - Taida, Takashi
AU  - Taida T
AD  - Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
FAU - Kasamatsu, Shingo
AU  - Kasamatsu S
AD  - Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
FAU - Okimoto, Kenichiro
AU  - Okimoto K
AD  - Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
FAU - Saito, Keiko
AU  - Saito K
AD  - Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
FAU - Maruoka, Daisuke
AU  - Maruoka D
AD  - Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
FAU - Nakagawa, Tomoo
AU  - Nakagawa T
AD  - Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
FAU - Suzuki, Takeshi
AU  - Suzuki T
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Chiba University, 
      Chiba, Japan.
FAU - Katsuno, Tatsuro
AU  - Katsuno T
AD  - Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
FAU - Arai, Makoto
AU  - Arai M
AD  - Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba 
      University, Chiba, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170601
PL  - United States
TA  - Clin Transl Gastroenterol
JT  - Clinical and translational gastroenterology
JID - 101532142
PMC - PMC5518945
COIS- Guarantor of the article: Makoto Arai, MD. Specific author contributions: 
      Designed the study, conducted the experiment, collected data, analyzed and 
      interpreted data, wrote the manuscript: Tomoaki Matsumura; designed the study, 
      analyzed and interpreted data, assisted in writing the manuscript: Hideaki 
      Ishigami and Makoto Arai; assisted in conducting the experiment and collecting 
      data: Takashi Taida, Shingo Kasamatsu, Kenichiro Okimoto, Keiko Saito, Daisuke 
      Maruoka, and Takeshi Suzuki; designed the study: Tomoo Nakagawa and Tatsuro 
      Katsuno; assisted in interpreting data and writing the manuscript: Mai Fujie. All 
      authors approved the final version of the manuscript. Financial support: None. 
      Potential competing interests: None.
EDAT- 2017/06/02 06:00
MHDA- 2017/06/02 06:01
PMCR- 2017/06/01
CRDT- 2017/06/02 06:00
PHST- 2017/03/30 00:00 [received]
PHST- 2017/04/24 00:00 [accepted]
PHST- 2017/06/02 06:00 [entrez]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2017/06/02 06:01 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - ctg201722 [pii]
AID - 10.1038/ctg.2017.22 [doi]
PST - epublish
SO  - Clin Transl Gastroenterol. 2017 Jun 1;8(6):e94. doi: 10.1038/ctg.2017.22.