PMID- 28571758
OWN - NLM
STAT- MEDLINE
DCOM- 20180406
LR  - 20211204
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 78
IP  - 7-8
DP  - 2017 Jul-Aug
TI  - Killer-cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) 
      class I genetic diversity in four South African populations.
PG  - 503-509
LID - S0198-8859(17)30088-5 [pii]
LID - 10.1016/j.humimm.2017.05.006 [doi]
AB  - Killer-cell Immunoglobulin-like Receptor (KIR) and Human Leukocyte Antigen (HLA) 
      genotypes vary considerably between individuals and populations due to KIR/HLA 
      allelic variation and variable haplotype configurations of KIR. HLA mediate 
      natural killer cell activity by serving as KIR ligands. KIR/HLA polymorphisms 
      associate with both disease susceptibility and severity. We determined the 
      frequencies of KIR, KIR genotypes and KIR-HLA combinations in 364 healthy 
      individuals from four South African populations. Study participants included 
      black African (n=167), Caucasian (n=97), Mixed ancestry (n=50) and Indian (n=50) 
      individuals. We identified 48 KIR genotypes that included two genotypes not 
      previously reported. Based on KIR gene content, Indian individuals represented 
      the most distinct group, showing the highest frequencies of KIR2DL2, KIR2DL5, 
      KIR2DS1, KIR2DS2, KIR2DS3 and KIR3DS1, the lowest frequencies of KIR2DL3, KIR2DS4 
      and KIR3DL1; and a KIR2DL4-negative individual. KIR2DS1 and KIR3DS1 were 
      infrequent in black African populations. HLA-C2 was more common in black African 
      individuals, while HLA-C1 predominated in the other populations. Indian 
      individuals were more likely to possess KIR2DL2 paired with HLA-C1, while 
      Caucasian individuals exhibited the highest frequencies of KIR2DL3 paired with 
      HLA-C1. This report provides comprehensive reference data for further study of 
      the roles of KIR/HLA in non-communicable and infectious diseases in South African 
      populations.
CI  - Copyright (c) 2017 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Gentle, Nikki L
AU  - Gentle NL
AD  - Centre for HIV and STIs, National Institute for Communicable Diseases, National 
      Health Laboratory Services, 1 Modderfontein Road, Johannesburg 2131, South 
      Africa; Faculty of Health Sciences, University of the Witwatersrand, 1 Jan Smuts 
      Avenue, Johannesburg 2000, South Africa.
FAU - Loubser, Shayne
AU  - Loubser S
AD  - Centre for HIV and STIs, National Institute for Communicable Diseases, National 
      Health Laboratory Services, 1 Modderfontein Road, Johannesburg 2131, South 
      Africa; Faculty of Health Sciences, University of the Witwatersrand, 1 Jan Smuts 
      Avenue, Johannesburg 2000, South Africa.
FAU - Paximadis, Maria
AU  - Paximadis M
AD  - Centre for HIV and STIs, National Institute for Communicable Diseases, National 
      Health Laboratory Services, 1 Modderfontein Road, Johannesburg 2131, South 
      Africa; Faculty of Health Sciences, University of the Witwatersrand, 1 Jan Smuts 
      Avenue, Johannesburg 2000, South Africa.
FAU - Puren, Adrian
AU  - Puren A
AD  - Centre for HIV and STIs, National Institute for Communicable Diseases, National 
      Health Laboratory Services, 1 Modderfontein Road, Johannesburg 2131, South 
      Africa; Faculty of Health Sciences, University of the Witwatersrand, 1 Jan Smuts 
      Avenue, Johannesburg 2000, South Africa.
FAU - Tiemessen, Caroline T
AU  - Tiemessen CT
AD  - Centre for HIV and STIs, National Institute for Communicable Diseases, National 
      Health Laboratory Services, 1 Modderfontein Road, Johannesburg 2131, South 
      Africa; Faculty of Health Sciences, University of the Witwatersrand, 1 Jan Smuts 
      Avenue, Johannesburg 2000, South Africa. Electronic address: 
      carolinet@nicd.ac.za.
LA  - eng
PT  - Journal Article
DEP - 20170529
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Ethnicity
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genetics, Population
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - India/ethnology
MH  - Infections/*genetics
MH  - Killer Cells, Natural/*immunology
MH  - Polymorphism, Genetic
MH  - Racial Groups
MH  - Receptors, KIR/*genetics
MH  - South Africa/epidemiology
OTO - NOTNLM
OT  - Caucasian
OT  - Coloured
OT  - HLA alleles
OT  - HLA ligands
OT  - Indian
OT  - KIR genes
OT  - KIR genotypes
OT  - Mixed ancestry
OT  - South African population
OT  - black African
EDAT- 2017/06/03 06:00
MHDA- 2018/04/07 06:00
CRDT- 2017/06/03 06:00
PHST- 2017/01/27 00:00 [received]
PHST- 2017/05/26 00:00 [revised]
PHST- 2017/05/26 00:00 [accepted]
PHST- 2017/06/03 06:00 [pubmed]
PHST- 2018/04/07 06:00 [medline]
PHST- 2017/06/03 06:00 [entrez]
AID - S0198-8859(17)30088-5 [pii]
AID - 10.1016/j.humimm.2017.05.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2017 Jul-Aug;78(7-8):503-509. doi: 10.1016/j.humimm.2017.05.006. 
      Epub 2017 May 29.