PMID- 28572274
OWN - NLM
STAT- MEDLINE
DCOM- 20170911
LR  - 20190127
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Print)
IS  - 0022-3050 (Linking)
VI  - 88
IP  - 9
DP  - 2017 Sep
TI  - CASPR2 autoantibodies are raised during pregnancy in mothers of children with 
      mental retardation and disorders of psychological development but not autism.
PG  - 718-721
LID - 10.1136/jnnp-2016-315251 [doi]
AB  - BACKGROUND, METHODS AND OBJECTIVES: Maternal autoantibodies to neuronal proteins 
      may be one cause of neurodevelopmental disorders. This exploratory study used the 
      Danish archived midgestational sera and their nationwide registers to search for 
      antibodies to the N-methyl-D-aspartate receptor (NMDAR) and contactin-associated 
      protein-like 2 (CASPR2) in maternal sera, and to relate them to subsequent 
      psychiatric diagnoses in the woman or her child. RESULTS: In a sample of 192 
      women, there was no association between antibody status and subsequent psychosis 
      in the mothers. However, NMDAR antibodies (n=4) or CASPR2 antibodies (n=1) were 
      identified in 5/11 (45.5%) women whose children were given a diagnosis of mild or 
      unspecified mental retardation or disorders of psychological and motor 
      development (collectively abbreviated as mental retardation and/or disorders of 
      psychological development (MR/DPD)) compared with 9/176 (5.1%) of the remaining 
      mother (p<0.001). These findings were followed up in a specifically selected 
      cohort, in which CASPR2 antibodies were detected in 7/171 (4.1%) mothers of 
      MR/DPD progeny, compared with only 1/171 (0.6%) control mother (p=0.067). The 
      combined sample showed a significantly higher frequency of CASPR2 antibodies in 
      mothers of MD/DPD children (p=0.01). These autoantibodies were not increased in 
      mothers of children with autistic spectrum disorder. CONCLUSIONS: These findings 
      complement the known roles of CASPR2 in brain development, and warrant further 
      epidemiological and experimental studies to clarify the role of CASPR2 and 
      possibly other antibodies in neurodevelopmental disorders.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text of 
      the article) 2017. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Coutinho, Ester
AU  - Coutinho E
AD  - Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
FAU - Jacobson, Leslie
AU  - Jacobson L
AD  - Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
FAU - Pedersen, Marianne Giortz
AU  - Pedersen MG
AD  - Department of Economics and Business Economics, National Centre for 
      Register-based Research, Aarhus University, Aarhus, Denmark.
AD  - iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, 
      Aarhus, Denmark.
FAU - Benros, Michael Eriksen
AU  - Benros ME
AD  - Department of Economics and Business Economics, National Centre for 
      Register-based Research, Aarhus University, Aarhus, Denmark.
AD  - iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, 
      Aarhus, Denmark.
AD  - Mental Health Centre Copenhagen, University of Copenhagen, Faculty of Health 
      Sciences, Copenhagen, Denmark.
FAU - Norgaard-Pedersen, Bent
AU  - Norgaard-Pedersen B
AD  - Department of Congenital Disorders, Danish Centre for Neonatal Screening, Statens 
      Serum Institut, Copenhagen, Denmark.
FAU - Mortensen, Preben Bo
AU  - Mortensen PB
AD  - Department of Economics and Business Economics, National Centre for 
      Register-based Research, Aarhus University, Aarhus, Denmark.
AD  - iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, 
      Aarhus, Denmark.
AD  - Centre for Integrated Register-Based Research (CIRRAU), Aarhus University, 
      Aarhus, Denmark.
FAU - Harrison, Paul J
AU  - Harrison PJ
AD  - Department of Psychiatry, University of Oxford, Oxford, UK.
AD  - Oxford Health NHS Foundation Trust, Oxford, Oxfordshire, UK.
FAU - Vincent, Angela
AU  - Vincent A
AD  - Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170601
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Autoantibodies)
RN  - 0 (CNTNAP2 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
CIN - J Neurol Neurosurg Psychiatry. 2017 Sep;88(9):713-714. PMID: 28596249
MH  - Autoantibodies/*immunology
MH  - Brain/immunology
MH  - Denmark
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Intellectual Disability/*diagnosis
MH  - Membrane Proteins/*immunology
MH  - Mothers/*psychology
MH  - Nerve Tissue Proteins/*immunology
MH  - Pregnancy
MH  - Receptors, N-Methyl-D-Aspartate
PMC - PMC5561372
OTO - NOTNLM
OT  - CASPR2
OT  - antibodies
OT  - autism
OT  - intellectual disability
COIS- Competing interests: AV and the University of Oxford hold a patent for LG11 and 
      CASPR2 antibodies, licensed to Euroimmun AG, and receive a proportion of 
      royalties for autoimmune encephalitis diagnostics.
EDAT- 2017/06/03 06:00
MHDA- 2017/09/12 06:00
PMCR- 2017/08/18
CRDT- 2017/06/03 06:00
PHST- 2016/11/09 00:00 [received]
PHST- 2017/03/20 00:00 [revised]
PHST- 2017/03/24 00:00 [accepted]
PHST- 2017/06/03 06:00 [pubmed]
PHST- 2017/09/12 06:00 [medline]
PHST- 2017/06/03 06:00 [entrez]
PHST- 2017/08/18 00:00 [pmc-release]
AID - jnnp-2016-315251 [pii]
AID - 10.1136/jnnp-2016-315251 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2017 Sep;88(9):718-721. doi: 
      10.1136/jnnp-2016-315251. Epub 2017 Jun 1.