PMID- 28573047
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2017
DP  - 2017
TI  - Simultaneous Fluorescein Angiography and Spectral Domain Optical Coherence 
      Tomography Correlate Retinal Thickness Changes to Vascular Abnormalities in an In 
      Vivo Mouse Model of Retinopathy of Prematurity.
PG  - 9620876
LID - 10.1155/2017/9620876 [doi]
LID - 9620876
AB  - BACKGROUND: Retinopathy of prematurity (ROP) is a condition of abnormal retinal 
      vascular development (RVD) in premature infants. Fluorescein angiography (FA) has 
      depicted phases (early, mid, late, and mature) of RVD in oxygen-induced 
      retinopathy (OIR) mice. We sought to establish the relationship between retinal 
      structural and vascular changes using simultaneous FA and spectral domain optical 
      coherence tomography (SD-OCT). METHOD: 63 mice were exposed to 77% oxygen at 
      postnatal day 7 (P7) for 5 days, while 63 mice remained in room air (RA). Total 
      retinal thickness (TRT), inner retinal thickness (IRT), and outer retinal 
      thickness (ORT) were calculated at early (P19), mid (P24), late (P32), and mature 
      (P47) phases of RVD. RESULTS: TRT was reduced in OIR (162.66 +/- 17.75 mum, n = 13) 
      compared to RA mice at P19 (197.57 +/- 3.49 mum, n = 14), P24, P32, and P49 (P < 
      0.0001). ORT was similar in RA and OIR mice at all ages (P > 0.05). IRT was 
      reduced in OIR (71.60 +/- 17.14 mum) compared to RA (103.07 +/- 3.47 mum) mice at P19 
      and all ages (P < 0.0001). CONCLUSION: We have shown the spatial and temporal 
      relationship between retinal structure and vascular development in OIR. 
      Significant inner retinal thinning in OIR mice persisted despite 
      revascularization of the capillary network; further studies will elucidate its 
      functional implications in ROP.
FAU - Mezu-Ndubuisi, Olachi J
AU  - Mezu-Ndubuisi OJ
AUID- ORCID: 0000-0002-6930-1747
AD  - Departments of Pediatrics, University of Wisconsin School of Medicine and Public 
      Health, Madison, WI, USA.
AD  - Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and 
      Public Health, Madison, WI, USA.
FAU - Taylor, Lauren K
AU  - Taylor LK
AD  - Departments of Pediatrics, University of Wisconsin School of Medicine and Public 
      Health, Madison, WI, USA.
FAU - Schoephoerster, Jamee A
AU  - Schoephoerster JA
AD  - Departments of Pediatrics, University of Wisconsin School of Medicine and Public 
      Health, Madison, WI, USA.
LA  - eng
PT  - Journal Article
DEP - 20170510
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC5442435
EDAT- 2017/06/03 06:00
MHDA- 2017/06/03 06:01
PMCR- 2017/05/10
CRDT- 2017/06/03 06:00
PHST- 2016/12/04 00:00 [received]
PHST- 2017/03/24 00:00 [revised]
PHST- 2017/03/28 00:00 [accepted]
PHST- 2017/06/03 06:00 [entrez]
PHST- 2017/06/03 06:00 [pubmed]
PHST- 2017/06/03 06:01 [medline]
PHST- 2017/05/10 00:00 [pmc-release]
AID - 10.1155/2017/9620876 [doi]
PST - ppublish
SO  - J Ophthalmol. 2017;2017:9620876. doi: 10.1155/2017/9620876. Epub 2017 May 10.