PMID- 28573785 OWN - NLM STAT- MEDLINE DCOM- 20180424 LR - 20180424 IS - 1522-726X (Electronic) IS - 1522-1946 (Linking) VI - 90 IP - 1 DP - 2017 Jul TI - Biomarker release after percutaneous coronary intervention in patients without established myocardial infarction as assessed by cardiac magnetic resonance with late gadolinium enhancement. PG - 87-93 LID - 10.1002/ccd.27125 [doi] AB - OBJECTIVES: This study aimed to evaluate the amount and pattern of cardiac biomarker release after elective percutaneous coronary intervention (PCI) in patients without evidence of a new myocardial infarction (MI) after the procedure as assessed by cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE). BACKGROUND: The release of myocardial necrosis biomarkers after PCI frequently occurs. However, the correlation between biomarker release and the diagnosis of procedure-related MI type 4a has been controversial. METHODS: Patients with normal baseline cardiac biomarkers who were referred for elective PCI were prospectively included. CMR with LGE was performed in all of the patients before and after the intervention. Measurements of troponin I (TnI) and creatine kinase MB fraction (CK-MB) were systematically performed before and after the procedure. Patients with a new LGE on the post-procedure CMR were excluded. RESULTS: Of the 56 patients with no evidence of a procedure-related MI as assessed by CMR after the PCI, 48 (85.1%) exhibited an elevation of TnI above the 99th percentile. In 32 patients (57.1%), the peak was greater than five times this limit. Additionally, 17 patients (30.4%) had a CK-MB peak above the 99th percentile limit, but this peak was greater than five times the 99th percentile in only two patients (3.6%). The median peak release of TnI was 0.290 (0.061-1.09) ng/mL, which was 7.25-fold higher than the 99th percentile. CONCLUSIONS: In contrast to CK-MB, an abnormal release of TnI often occurs after an elective PCI procedure, despite the absence of a new LGE on CMR. CI - (c) 2017 Wiley Periodicals, Inc. FAU - Vieira de Melo, Rodrigo Morel AU - Vieira de Melo RM AUID- ORCID: 0000-0003-3927-778X AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. FAU - Hueb, Whady AU - Hueb W AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. FAU - Nomura, Cesar Higa AU - Nomura CH AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. FAU - Ribeiro da Silva, Expedito Eustaquio AU - Ribeiro da Silva EE AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. FAU - Villa, Alexandre Volney AU - Villa AV AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. FAU - Oikawa, Fernando Teiichi Costa AU - Oikawa FTC AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. FAU - da Costa, Leandro Menezes Alves AU - da Costa LMA AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. FAU - Rezende, Paulo Cury AU - Rezende PC AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. FAU - Garzillo, Cibele Larrosa AU - Garzillo CL AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. FAU - Lima, Eduardo Gomes AU - Lima EG AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. FAU - Franchini Ramires, Jose Antonio AU - Franchini Ramires JA AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. FAU - Kalil Filho, Roberto AU - Kalil Filho R AD - Department of Atherosclerosis, Heart Institute (InCor) of the University of Sao Paulo, Sao Paulo, SP, Brazil. LA - eng PT - Case Reports DEP - 20170602 PL - United States TA - Catheter Cardiovasc Interv JT - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions JID - 100884139 RN - 0 (Biomarkers) RN - 0 (Contrast Media) RN - 0 (Heterocyclic Compounds) RN - 0 (Organometallic Compounds) RN - 0 (Troponin I) RN - 99J2XUF1JT (gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate) RN - EC 2.7.3.2 (Creatine Kinase, MB Form) SB - IM MH - Aged MH - Biomarkers/blood MH - Contrast Media/*administration & dosage MH - Coronary Angiography MH - Creatine Kinase, MB Form/*blood MH - Electrocardiography MH - Female MH - Fibrosis MH - Heterocyclic Compounds/*administration & dosage MH - Humans MH - *Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Myocardial Infarction/*blood/*diagnostic imaging/etiology MH - Myocardium/*metabolism/pathology MH - Necrosis MH - Organometallic Compounds/*administration & dosage MH - Percutaneous Coronary Intervention/*adverse effects/instrumentation MH - Predictive Value of Tests MH - Prospective Studies MH - Reproducibility of Results MH - Risk Factors MH - Stents MH - Treatment Outcome MH - Troponin I/*blood MH - Up-Regulation OTO - NOTNLM OT - cardiac magnetic resonance imaging OT - coronary artery disease OT - percutaneous coronary intervention OT - troponin EDAT- 2017/06/03 06:00 MHDA- 2018/04/25 06:00 CRDT- 2017/06/03 06:00 PHST- 2016/12/20 00:00 [received] PHST- 2017/04/05 00:00 [revised] PHST- 2017/04/23 00:00 [accepted] PHST- 2017/06/03 06:00 [pubmed] PHST- 2018/04/25 06:00 [medline] PHST- 2017/06/03 06:00 [entrez] AID - 10.1002/ccd.27125 [doi] PST - ppublish SO - Catheter Cardiovasc Interv. 2017 Jul;90(1):87-93. doi: 10.1002/ccd.27125. Epub 2017 Jun 2.