PMID- 28573997
OWN - NLM
STAT- MEDLINE
DCOM- 20170919
LR  - 20220408
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 65
IP  - 5
DP  - 2017 May
TI  - Allergen-specific exposure associated with high immunoglobulin E and eye rubbing 
      predisposes to progression of keratoconus.
PG  - 399-402
LID - 10.4103/ijo.IJO_217_17 [doi]
AB  - We report two male children with persistent allergic eye disease (AED) and 
      keratoconus (KC). Both presented with symptoms of vernal keratoconjunctivitis and 
      decreased vision. In view of unrelenting AED, serum immunoglobulin E (IgE) 
      quantification and identification of specific allergens were advised. Increased 
      serum IgE levels were observed in both cases. Sunflower and sheep wool were 
      identified as specific allergens for the first and second patient respectively by 
      skin patch test. There was complete resolution of symptoms of AED in both 
      patients following avoidance of causative allergens. However, the progression of 
      KC in both eyes of the first patient and one eye of the second patient was 
      observed. They were advised collagen cross-linking. Elevated serum IgE indicates 
      the presence of systemic allergy. Avoiding implicated allergens help alleviate 
      ocular symptoms. Using serum IgE and identifying specific allergen can guide in 
      the treatment of AED and thus prevent progressive KC due to eye rubbing and 
      resulting inflammation.
FAU - Shetty, Rohit
AU  - Shetty R
AD  - Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bengaluru, 
      Karnataka, India.
FAU - Sureka, Shraddha
AU  - Sureka S
AD  - Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bengaluru, 
      Karnataka, India.
FAU - Kusumgar, Pallak
AU  - Kusumgar P
AD  - Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bengaluru, 
      Karnataka, India.
FAU - Sethu, Swaminathan
AU  - Sethu S
AD  - GROW Research Laboratory, Narayana Nethralaya Foundation, Bengaluru, Karnataka, 
      India.
FAU - Sainani, Kanchan
AU  - Sainani K
AD  - Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bengaluru, 
      Karnataka, India.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
EIN - Indian J Ophthalmol. 2017 Jul;65(7):642-643. PMID: 28724834
CIN - Indian J Ophthalmol. 2017 Sep;65(9):899-900. PMID: 28905846
CIN - Indian J Ophthalmol. 2017 Sep;65(9):900-901. PMID: 28905847
MH  - Allergens/*adverse effects/immunology
MH  - Biomarkers/blood
MH  - Child
MH  - Conjunctivitis, Allergic/*complications/diagnosis/immunology
MH  - Corneal Topography
MH  - Disease Progression
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Keratoconus/diagnosis/*etiology/immunology
MH  - Male
PMC - PMC5565884
COIS- There are no conflicts of interest.
EDAT- 2017/06/03 06:00
MHDA- 2017/09/20 06:00
PMCR- 2017/05/01
CRDT- 2017/06/03 06:00
PHST- 2017/06/03 06:00 [entrez]
PHST- 2017/06/03 06:00 [pubmed]
PHST- 2017/09/20 06:00 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2017_65_5_399_207440 [pii]
AID - IJO-65-399 [pii]
AID - 10.4103/ijo.IJO_217_17 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2017 May;65(5):399-402. doi: 10.4103/ijo.IJO_217_17.