PMID- 28574437
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20240326
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 14
IP  - 6
DP  - 2017 Jun 2
TI  - The Influence of Quercetin on Maternal Immunity, Oxidative Stress, and 
      Inflammation in Mice with Exposure of Fine Particulate Matter during Gestation.
LID - 10.3390/ijerph14060592 [doi]
LID - 592
AB  - The objective is to investigate the influence of PM(2.5) exposure on peripheral 
      blood lymphocyte subsets in pregnant mice and the antagonism of quercetin on 
      adverse effects induced by PM(2.5) exposure. Pregnant mice were randomly divided 
      into control group, PM(2.5) model group and 3 quercetin intervention groups. Dams 
      in all groups except the control group were exposed to PM(2.5) suspension by 
      intratracheal instillation on gestational day (GD) 3, 6, 9, 12 and 15. Meanwhile, 
      each dam was given 0.15% carboxymethylcellulose sodium (CMCS) (control group 
      & PM(2.5) model group) and different doses of quercetin (quercetin 
      intervention groups) by gavage once a day from GD0 to GD17. The percentage of 
      lymphocyte subsets, Biomarkers of systemic inflammation injuries (IL-2, IL-6, 
      IL-8 & TNF-alpha) and oxidative stress indicators (CAT, GSH & HO-1) in 
      peripheral blood of the dams were analyzed. The number of T cells increased, 
      accompanied by increased level of IL-2, IL-6, IL-8 and HO-1 due to PM(2.5) 
      exposure. Less CD4+ and CD8+ T cells were counted in 100 mg/kg quercetin 
      intervention group, compared with PM(2.5) model group. Quercetin may inhibit 
      cytokine production, especially in IL-6 and IL-8 and may upgrade the level of 
      HO-1. Our findings indicate that PM(2.5) could significantly influence the 
      distribution of T-lymphocyte subsets, activate inflammatory reaction and elevate 
      oxidative stress level in peripheral blood of pregnant mice. Certain dose of 
      quercetin administration during pregnancy may protect the dams against the 
      adverse effects through various ways.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. liuwei19560912@163.com.
FAU - Zhang, Minjia
AU  - Zhang M
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. minjiazh@163.com.
FAU - Feng, Jinqiu
AU  - Feng J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. fengjinqiu1992@163.com.
FAU - Fan, Aiqin
AU  - Fan A
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. fanaiqin1990@163.com.
FAU - Zhou, Yalin
AU  - Zhou Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. zhouyalin2017@163.com.
FAU - Xu, Yajun
AU  - Xu Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. xuyajun@bjmu.edu.cn.
AD  - Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food 
      Safety, Peking University, Beijing 100191, China. xuyajun@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170602
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Particulate Matter)
RN  - 0 (Protective Agents)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cytokines/genetics/metabolism
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Inflammation/*chemically induced/metabolism
MH  - Lymphocyte Subsets/drug effects
MH  - Mice
MH  - Oxidative Stress/*drug effects
MH  - Particulate Matter/*adverse effects
MH  - Pregnancy
MH  - Protective Agents/pharmacology
MH  - Quercetin/*pharmacology
MH  - Random Allocation
PMC - PMC5486278
OTO - NOTNLM
OT  - PM2.5
OT  - inflammation
OT  - lymphocyte subset
OT  - oxidative stress
OT  - pregnancy
OT  - quercetin
COIS- The authors declare no conflict of interest.
EDAT- 2017/06/03 06:00
MHDA- 2017/10/24 06:00
PMCR- 2017/06/01
CRDT- 2017/06/03 06:00
PHST- 2017/04/03 00:00 [received]
PHST- 2017/05/24 00:00 [revised]
PHST- 2017/05/26 00:00 [accepted]
PHST- 2017/06/03 06:00 [entrez]
PHST- 2017/06/03 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - ijerph14060592 [pii]
AID - ijerph-14-00592 [pii]
AID - 10.3390/ijerph14060592 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2017 Jun 2;14(6):592. doi: 
      10.3390/ijerph14060592.