PMID- 28575038 OWN - NLM STAT- MEDLINE DCOM- 20170911 LR - 20181113 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 12 IP - 6 DP - 2017 TI - Plasma brain-derived neurotrophic factor concentration is a predictor of chronic kidney disease in patients with cardiovascular risk factors - Hyogo Sleep Cardio-Autonomic Atherosclerosis study. PG - e0178686 LID - 10.1371/journal.pone.0178686 [doi] LID - e0178686 AB - BACKGROUND: Brain-derived neurotrophic factor (BDNF) has been shown to have protective effects against cardiovascular diseases and death through neural and non-neural pathways via tropomyosin-related kinase B signaling. However, it is not known whether plasma BDNF concentration is a predictor of chronic kidney disease (CKD). DESIGN: This study was conducted as a prospective cohort study as part of the Hyogo Sleep Cardio-Autonomic Atherosclerosis. METHODS: We measured plasma BDNF concentration in 324 patients without CKD, defined as an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2, and with cardiovascular risk factors. As potential confounders, sleep condition, nocturnal hypertension, and autonomic function were quantitatively examined. The patients were followed for a median 37 months (range 2-59 months) and occurrence of CKD was noted. RESULTS: Plasma BDNF concentration was significantly and independently associated with CKD development, which occurred in 38 patients (11.7%). Kaplan-Meier analysis revealed that patients with reduced plasma BDNF concentration exhibited a significantly (p = 0.029) greater number of CKD events as compared to those with a higher concentration. Moreover, comparisons of key subgroups showed that the risk of CKD in association with low plasma BDNF concentration was more prominent in patients with a greater reduction of nocturnal systolic blood pressure, better movement index, higher standard deviations of the NN(RR) interval or average NN(RR) interval for each 5-minute period, and without past cardiovascular disease events, smoking habit, or albuminuria. CONCLUSIONS: Plasma BDNF concentration is an independent predictor for development of CKD in patients with cardiovascular risk factors. FAU - Kurajoh, Masafumi AU - Kurajoh M AUID- ORCID: 0000-0002-2973-8143 AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. AD - Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan. FAU - Kadoya, Manabu AU - Kadoya M AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Morimoto, Akiko AU - Morimoto A AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Miyoshi, Akio AU - Miyoshi A AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Kanzaki, Akinori AU - Kanzaki A AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Kakutani-Hatayama, Miki AU - Kakutani-Hatayama M AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Hamamoto, Kae AU - Hamamoto K AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Shoji, Takuhito AU - Shoji T AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Moriwaki, Yuji AU - Moriwaki Y AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Yamamoto, Tetsuya AU - Yamamoto T AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Inaba, Masaaki AU - Inaba M AD - Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan. FAU - Namba, Mitsuyoshi AU - Namba M AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Koyama, Hidenori AU - Koyama H AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. LA - eng PT - Journal Article DEP - 20170602 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Aged MH - Atherosclerosis/epidemiology MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Cardiovascular Diseases/blood/*epidemiology MH - Comorbidity MH - Diabetes Mellitus/epidemiology MH - Dyslipidemias/epidemiology MH - Female MH - Follow-Up Studies MH - Glomerular Filtration Rate MH - Humans MH - Japan/epidemiology MH - Male MH - Middle Aged MH - Obesity/epidemiology MH - Proportional Hazards Models MH - Prospective Studies MH - Renal Insufficiency, Chronic/*blood MH - Risk Factors MH - Sleep Wake Disorders/epidemiology MH - Smoking/epidemiology PMC - PMC5456118 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2017/06/03 06:00 MHDA- 2017/09/12 06:00 PMCR- 2017/06/02 CRDT- 2017/06/03 06:00 PHST- 2017/01/19 00:00 [received] PHST- 2017/05/17 00:00 [accepted] PHST- 2017/06/03 06:00 [entrez] PHST- 2017/06/03 06:00 [pubmed] PHST- 2017/09/12 06:00 [medline] PHST- 2017/06/02 00:00 [pmc-release] AID - PONE-D-17-02520 [pii] AID - 10.1371/journal.pone.0178686 [doi] PST - epublish SO - PLoS One. 2017 Jun 2;12(6):e0178686. doi: 10.1371/journal.pone.0178686. eCollection 2017.