PMID- 28575042
OWN - NLM
STAT- MEDLINE
DCOM- 20170915
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 6
DP  - 2017
TI  - TNF-alpha -308 A allele is associated with an increased risk of distant metastasis in 
      rectal cancer patients from Southwestern China.
PG  - e0178218
LID - 10.1371/journal.pone.0178218 [doi]
LID - e0178218
AB  - Tumor necrosis factor-alpha (TNF-alpha), an important factor in systematic inflammation, 
      is reportedly involved in several cancer types. The TNF-alpha -308 G>A (rs1800629) 
      polymorphism in the promoter region influences TNF-alpha production. The association 
      between TNF-alpha -308 G>A polymorphism and colorectal cancer (CRC) is not fully 
      understood, especially the connections between TNF-alpha -308 G>A polymorphism and 
      clinical features of CRC. In this study, TNF-alpha -308 G>A polymorphism was 
      genotyped in 1140 individuals with or without CRC from Southwestern China. In 
      case-control studies, we found no association between TNF-alpha -308 G>A polymorphism 
      and CRC risk. Analysis of the correlations between TNF-alpha -308 G>A polymorphism 
      and clinical features of CRC revealed that TNF-alpha -308 A allele was associated 
      with higher body mass index (BMI) larger tumor size, and distant tumor metastasis 
      in all CRC patients. Notably, rectal cancer (a subtype of CRC) patients with 
      TNF-alpha -308 A allele had a very high risk of distant tumor metastasis [odds ratio 
      (OR) = 4.481; 95% confidence interval (CI): 2.072-9.693; P = 0.00025]. The 
      association between TNF-alpha -308 A allele and distant tumor metastasis remained 
      even significant after adjusting all clinical characteristics (OR = 7.099; 95% 
      CI: 2.482-20.301; P = 0.000256) in rectal cancer patients. Our results suggested 
      that TNF-alpha -308 A allele was significantly associated with distant tumor 
      metastasis in rectal cancer patients.
FAU - Li, Zhen
AU  - Li Z
AD  - Department of Gastrointestinal Surgery, Institute of Gastroenterology, The First 
      Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
AD  - Kunming Digestive Disease Treatment Engineering Technology Center, Kunming, 
      Yunnan, China.
FAU - Li, Shu-An
AU  - Li SA
AD  - Department of Gastroenterology, Institute of Gastroenterology, The First 
      Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Sun, Ya
AU  - Sun Y
AD  - Department of Breast Surgery, Yunnan Tumor Hospital, The Third Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Breast Surgery, Yunnan Tumor Hospital, The Third Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Li, Wen-Liang
AU  - Li WL
AD  - Department of Oncologic Surgery, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, Yunnan, China.
FAU - Yang, Li
AU  - Yang L
AD  - Department of Clinical Laboratory, Yunnan Tumor Hospital, The Third Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Duan, Yong
AU  - Duan Y
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan, China.
FAU - Li, Jingyu
AU  - Li J
AD  - Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan, 
      China.
FAU - Guo, Hao
AU  - Guo H
AD  - Department of Cardiology, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, Yunnan, China.
FAU - Zou, Tian-Ning
AU  - Zou TN
AD  - Department of Breast Surgery, Yunnan Tumor Hospital, The Third Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Li, Yunlong
AU  - Li Y
AUID- ORCID: 0000-0002-2301-2392
AD  - Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan, 
      China.
AD  - The First People's Hospital of Yunnan Province (The Affiliated of Kunming 
      University of and Technology), Kunming, Yunnan, China.
FAU - Wang, Kun-Hua
AU  - Wang KH
AD  - Department of Gastrointestinal Surgery, Institute of Gastroenterology, The First 
      Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
AD  - Kunming Digestive Disease Treatment Engineering Technology Center, Kunming, 
      Yunnan, China.
LA  - eng
PT  - Journal Article
DEP - 20170602
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - China
MH  - Colon/metabolism/*pathology
MH  - Colorectal Neoplasms/*genetics/*pathology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis/genetics/pathology
MH  - *Polymorphism, Single Nucleotide
MH  - Rectum/metabolism/*pathology
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC5456043
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/06/03 06:00
MHDA- 2017/09/16 06:00
PMCR- 2017/06/02
CRDT- 2017/06/03 06:00
PHST- 2017/02/12 00:00 [received]
PHST- 2017/05/09 00:00 [accepted]
PHST- 2017/06/03 06:00 [entrez]
PHST- 2017/06/03 06:00 [pubmed]
PHST- 2017/09/16 06:00 [medline]
PHST- 2017/06/02 00:00 [pmc-release]
AID - PONE-D-17-05667 [pii]
AID - 10.1371/journal.pone.0178218 [doi]
PST - epublish
SO  - PLoS One. 2017 Jun 2;12(6):e0178218. doi: 10.1371/journal.pone.0178218. 
      eCollection 2017.