PMID- 28575405 OWN - NLM STAT- MEDLINE DCOM- 20180430 LR - 20220321 IS - 1522-9645 (Electronic) IS - 0195-668X (Print) IS - 0195-668X (Linking) VI - 38 IP - 29 DP - 2017 Aug 1 TI - Long-term exposure to road traffic noise, ambient air pollution, and cardiovascular risk factors in the HUNT and lifelines cohorts. PG - 2290-2296 LID - 10.1093/eurheartj/ehx263 [doi] AB - AIMS: Blood biochemistry may provide information on associations between road traffic noise, air pollution, and cardiovascular disease risk. We evaluated this in two large European cohorts (HUNT3, Lifelines). METHODS AND RESULTS: Road traffic noise exposure was modelled for 2009 using a simplified version of the Common Noise Assessment Methods in Europe (CNOSSOS-EU). Annual ambient air pollution (PM10, NO2) at residence was estimated for 2007 using a Land Use Regression model. The statistical platform DataSHIELD was used to pool data from 144 082 participants aged >/=20 years to enable individual-level analysis. Generalized linear models were fitted to assess cross-sectional associations between pollutants and high-sensitivity C-reactive protein (hsCRP), blood lipids and for (Lifelines only) fasting blood glucose, for samples taken during recruitment in 2006-2013. Pooling both cohorts, an inter-quartile range (IQR) higher day-time noise (5.1 dB(A)) was associated with 1.1% [95% confidence interval (95% CI: 0.02-2.2%)] higher hsCRP, 0.7% (95% CI: 0.3-1.1%) higher triglycerides, and 0.5% (95% CI: 0.3-0.7%) higher high-density lipoprotein (HDL); only the association with HDL was robust to adjustment for air pollution. An IQR higher PM10 (2.0 microg/m3) or NO2 (7.4 microg/m3) was associated with higher triglycerides (1.9%, 95% CI: 1.5-2.4% and 2.2%, 95% CI: 1.6-2.7%), independent of adjustment for noise. Additionally for NO2, a significant association with hsCRP (1.9%, 95% CI: 0.5-3.3%) was seen. In Lifelines, an IQR higher noise (4.2 dB(A)) and PM10 (2.4 microg/m3) was associated with 0.2% (95% CI: 0.1-0.3%) and 0.6% (95% CI: 0.4-0.7%) higher fasting glucose respectively, with both remaining robust to adjustment for air/noise pollution. CONCLUSION: Long-term exposures to road traffic noise and ambient air pollution were associated with blood biochemistry, providing a possible link between road traffic noise/air pollution and cardio-metabolic disease risk. CI - Published on behalf of the European Society of Cardiology. All rights reserved. (c) The Author 2017. For permissions, please email: journals.permissions@oup.com. FAU - Cai, Yutong AU - Cai Y AD - Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK. FAU - Hansell, Anna L AU - Hansell AL AD - Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK. AD - Directorate of Public Health and Primary Care, Imperial College Healthcare NHS Trust, London, UK. FAU - Blangiardo, Marta AU - Blangiardo M AD - Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK. FAU - Burton, Paul R AU - Burton PR AD - Data to Knowledge (D2K) Research Group, University of Bristol, Oakfield Grove, Bristol BS8 2BN, UK. AD - Maelstrom Research Program, Public Population Project in Genomics and Society (P G), 740 Dr Penfield Avenue, Suite 5104, H3A 0G1, Montreal, Canada. CN - BioSHaRE FAU - de Hoogh, Kees AU - de Hoogh K AD - Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK. AD - Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland. AD - University of Basel, Petersplatz 1, 4003 Basel, Switzerland. FAU - Doiron, Dany AU - Doiron D AD - Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland. AD - University of Basel, Petersplatz 1, 4003 Basel, Switzerland. AD - Child Health and Human Development Program, Research Institute of the McGill University Health Centre, McGill University, 2155 Guy St, H3H 2L9 Montreal, Canada. FAU - Fortier, Isabel AU - Fortier I AD - Maelstrom Research Program, Public Population Project in Genomics and Society (P G), 740 Dr Penfield Avenue, Suite 5104, H3A 0G1, Montreal, Canada. AD - Child Health and Human Development Program, Research Institute of the McGill University Health Centre, McGill University, 2155 Guy St, H3H 2L9 Montreal, Canada. FAU - Gulliver, John AU - Gulliver J AD - Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK. FAU - Hveem, Kristian AU - Hveem K AD - Department of Public Health and Nursing, Norwegian University of Science and Technology, Forskningsvegen 2, 7600 Levanger, Trondheim, Norway. FAU - Mbatchou, Stephane AU - Mbatchou S AD - Child Health and Human Development Program, Research Institute of the McGill University Health Centre, McGill University, 2155 Guy St, H3H 2L9 Montreal, Canada. FAU - Morley, David W AU - Morley DW AD - Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK. FAU - Stolk, Ronald P AU - Stolk RP AD - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands. FAU - Zijlema, Wilma L AU - Zijlema WL AD - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands. AD - Barcelona Institute for Global Health (ISGlobal), Centre for Research in Environmental Epidemiology (CREAL), Doctor Aiguader 88, 08003 Barcelona, Spain. AD - Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain. AD - CIBER Epidemiologia y Salud Publica (CIBERESP), Melchor Fernandez Almagro, 3-5, 28029 Madrid, Spain. FAU - Elliott, Paul AU - Elliott P AD - Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK. FAU - Hodgson, Susan AU - Hodgson S AD - Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK. LA - eng GR - MR/M501633/1/MRC_/Medical Research Council/United Kingdom GR - MC_PC_13040/MRC_/Medical Research Council/United Kingdom GR - MR/L01341X/1/MRC_/Medical Research Council/United Kingdom GR - MR/K006525/1/MRC_/Medical Research Council/United Kingdom GR - MR/K007017/1/MRC_/Medical Research Council/United Kingdom GR - MR/L01632X/1/MRC_/Medical Research Council/United Kingdom GR - WT_/Wellcome Trust/United Kingdom GR - MR/M501633/2/MRC_/Medical Research Council/United Kingdom GR - G0801056/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Multicenter Study PL - England TA - Eur Heart J JT - European heart journal JID - 8006263 RN - 0 (Air Pollutants) SB - IM CIN - Eur Heart J. 2017 Aug 1;38(29):2297-2299. PMID: 28641401 MH - Adult MH - Air Pollutants/toxicity MH - Air Pollution/*adverse effects MH - Cardiovascular Diseases/*etiology MH - Environmental Exposure/adverse effects MH - Europe/epidemiology MH - Humans MH - Male MH - Middle Aged MH - Noise, Transportation/*adverse effects/statistics & numerical data MH - Prospective Studies MH - Risk Factors MH - Socioeconomic Factors PMC - PMC5837618 OTO - NOTNLM OT - Air pollution OT - Blood glucose OT - Blood lipids OT - Systemic inflammation OT - Traffic noise EDAT- 2017/06/03 06:00 MHDA- 2018/05/01 06:00 PMCR- 2018/08/01 CRDT- 2017/06/03 06:00 PHST- 2016/09/14 00:00 [received] PHST- 2017/04/28 00:00 [accepted] PHST- 2017/06/03 06:00 [pubmed] PHST- 2018/05/01 06:00 [medline] PHST- 2017/06/03 06:00 [entrez] PHST- 2018/08/01 00:00 [pmc-release] AID - 3858093 [pii] AID - ehx263 [pii] AID - 10.1093/eurheartj/ehx263 [doi] PST - ppublish SO - Eur Heart J. 2017 Aug 1;38(29):2290-2296. doi: 10.1093/eurheartj/ehx263.